Species

KNApSAcK Entry

Organism name Machilus japonica
Genus Machilus
Family Lauraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Persea japonica
Linked NCBI taxonomy ID 325535
Linked level species

Family

Family in NCBI taxonomy Lauraceae
ID 3433

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Magnoliophyta
ID 3398

Metabolite list (8)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00000697 External link 512 (-)-Machilusin
CHEMBL471177
CHEMBL469499
CHEMBL559937
No. 38 No. 21
C00002611 External link 512 Licarin A
/ (-)-Licarin A
CHEMBL259731
CHEMBL463526
CHEMBL1732407
9 / 7 / 3 No. 215 No. 23
C00047850 External link 512 dl-Coclaurine
CHEMBL256448
CHEMBL453291
CHEMBL446211
8 / 17 / 10 No. 253 No. 4
C00007213 External link 512 (-)-Galbacin
CHEMBL1980140
CHEMBL2151191
2 / 0 / 0 No. 621 No. 21
C00002605 External link 512 (+)-Galbacin
CHEMBL1980140
CHEMBL2151191
2 / 0 / 0 No. 621 No. 21
C00047722 External link 512 Apigenosylide B
/ (+)-Apigenosylide B
CHEMBL538176
No. 4037
C00047723 External link 512 Apigenosylide C
/ (-)-Apigenosylide C
CHEMBL558750
No. 4037
C00047721 External link 512 Apigenosylide A
/ (+)-Apigenosylide A
CHEMBL540481
No. 4037

Human Protein / Gene in interactions

17 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q16539 Mitogen-activated protein kinase 14 p38 C00002605 C00007213 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00002611 C00047850 0 / 0
O75496 Geminin Unclassified protein C00002611 C00047850 0 / 0
P45984 Mitogen-activated protein kinase 9 Jnk C00002605 C00007213 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00002611 0 / 0
P39748 Flap endonuclease 1 Enzyme C00002611 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00002611 2 / 0
P04062 Glucosylceramidase Enzyme C00047850 6 / 4
P37840 Alpha-synuclein Unclassified protein C00002611 4 / 2
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00047850 7 / 3
Q9UNA4 DNA polymerase iota Enzyme C00002611 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00002611 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00047850 4 / 3
B2RXH2 Lysine-specific demethylase 4E Enzyme C00047850 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00047850 0 / 0
P14618 Pyruvate kinase PKM Enzyme C00047850 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00002611 1 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (23)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#114500 Colorectal cancer; crc P84022
#127750 Dementia, lewy body; dlb P37840
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#174800 Mccune-albright syndrome; mas P63092
#166350 Osseous heteroplasia, progressive; poh P63092
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P04062
P37840
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (11)

KEGG name UniProt
H00066 Lewy body dementia (LBD) P04062 (related)
P37840 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)