Species

KNApSAcK Entry

Organism name Stephania delavayi Diels
Genus Stephania
Family Menispermaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Stephania delavayi
Linked NCBI taxonomy ID 216145
Linked level species

Family

Family in NCBI taxonomy Menispermaceae
ID 3455

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (9)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00025313 External link 512 Isotetrandrine
/ Isosinomenine A
/ O-Methylberbamine
/ O,O-Dimethylobamegine
/ O,O'-Dimethylobamegine
/ O,O-Dimethylstepholine
/ O,O'-Dimethylstepholine
CHEMBL176045
CHEMBL367260
CHEMBL445477
CHEMBL449690
CHEMBL504958
CHEMBL504757
26 / 23 / 48 No. 10 No. 4
C00025310 External link 512 Homoaromoline
/ (+)-Homoaromoline
/ (+)-Thalrugosamine
CHEMBL507220
CHEMBL503522
CHEMBL509855
CHEMBL1185978
No. 10 No. 4
C00025604 External link 512 Cycleanine
/ (-)-Cycleanine
CHEMBL1711244
CHEMBL1983719
C037098
7 / 1 / 1 No. 10 No. 4
C00025607 External link 512 NSC 251699
/ L-Dicentrine
/ (-)-Dicentrine
/ (R)-(-)-Dicentrine
CHEMBL464748
CHEMBL478754
15 / 20 / 16 No. 20 No. 4
C00026150 External link 512 Tetrahydropalmatine
/ dl-Tetrahydropalmatine
/ (+/-)-Tetrahydropalmatine
CHEMBL187892
CHEMBL487182
CHEMBL2334889
8 / 5 / 2 No. 37 No. 4
C00025913 External link 512 Isostephodeline
/ (+)-Isostephodeline
/ (+)-14-Epierromangine
No. 346 No. 4
C00025097 External link 512 16-Oxodelavaine
No. 559 No. 4
C00025105 External link 512 Delavaine
No. 2981
C00025298 External link 512 Delavaine
/ (-)-Delavaine
No. 2981

Human Protein / Gene in interactions

43 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
O75164 Lysine-specific demethylase 4A Enzyme C00025313 C00025604 C00025607 0 / 0
O75496 Geminin Unclassified protein C00025313 C00025604 C00025607 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00025313 C00025604 C00025607 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00025313 C00026150 0 / 1
Q99700 Ataxin-2 Unclassified protein C00025313 C00025604 1 / 1
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00025313 C00025607 1 / 2
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00025313 C00025604 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00025313 C00025604 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00025313 C00025607 1 / 0
P39748 Flap endonuclease 1 Enzyme C00025313 C00025607 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00025313 1 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 C00025607 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00025313 0 / 1
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00025607 1 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00026150 2 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme C00025313 0 / 0
P02545 Prelamin-A/C Unclassified protein C00025607 11 / 10
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00025313 2 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00025313 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00026150 1 / 0
P06746 DNA polymerase beta Enzyme C00025607 0 / 0
P08183 Multidrug resistance protein 1 drug C00025313 1 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00025313 0 / 0
P06280 Alpha-galactosidase A Enzyme C00025313 1 / 1
P13726 Tissue factor Membrane receptor C00026150 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00025313 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00025313 0 / 0
P03372 Estrogen receptor NR3A1 C00026150 1 / 1
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00026150 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00025313 1 / 1
P21728 D(1A) dopamine receptor Dopamine receptor C00026150 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00025313 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00025313 4 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00025607 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00025607 0 / 0
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00026150 1 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00025607 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00025313 1 / 1
P04637 Cellular tumor antigen p53 Transcription Factor C00025313 7 / 37
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00025604 0 / 0
O00255 Menin Unclassified protein C00025313 2 / 5
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00025607 2 / 1
P43351 DNA repair protein RAD52 homolog Unclassified protein C00025607 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (45)

OMIM preferred title UniProt
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103780 Alcohol dependence P14416
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P84022
Q14191
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#612244 Inflammatory bowel disease 13; ibd13 P08183
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#211980 Lung cancer P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#614674 Periodic fever, menstrual cycle-dependent P08908
#172700 Pick disease of brain P10636
#275210 Restrictive dermopathy, lethal P02545
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277700 Werner syndrome; wrn Q14191

KEGG DISEASE (62)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04637 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00125 Fabry disease P06280 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)