Species

KNApSAcK Entry

Organism name Sinomenium acutum Rehder & Wilson
Genus Sinomenium
Family Menispermaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Sinomenium
Linked NCBI taxonomy ID 152362
Linked level genus

Family

Family in NCBI taxonomy Menispermaceae
ID 3455

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (10)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00025775 External link 512 Bianfugenine
/ Dauriporphine
C046294
No. 74
C00026127 External link 512 Dehydrodiscretine
/ Pseudojatrorrhizine
CHEMBL220527
No. 155 No. 4
C00026048 External link 512 Stepharanin
/ Stepharanine
CHEMBL251229
1 / 0 / 1 No. 155 No. 4
C00026130 External link 512 Epiberberine
CHEMBL1197637
C061432
22 / 34 / 27 No. 155 No. 4
C00025667 External link 512 (+)-Laurifoline
CHEMBL235429
No. 286 No. 4
C00025596 External link 512 8,14-Dihydrosalutaridine
/ (-)-8,14-dihydrosalutaridine
No. 346 No. 4
C00025629 External link 512 Sinoacutine
/ (-)-Sinoacutine
/ (-)-Salutaridine
CHEMBL402782
CHEMBL404097
3 / 4 / 2 No. 426 No. 4
C00025765 External link 512 Acutumine
CHEMBL391628
CHEMBL391835
CHEMBL1716763
1 / 0 / 0 No. 915
C00025858 External link 512 Disinomenine
/ (+)-Disinomenine
CHEMBL255668
No. 3422
C00026034 External link 512 Sinomendine
No. 4791

Human Protein / Gene in interactions

27 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q16637 Survival motor neuron protein Unclassified protein C00026130 4 / 1
P06746 DNA polymerase beta Enzyme C00026130 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00026130 0 / 0
P02545 Prelamin-A/C Unclassified protein C00026130 11 / 10
P24941 Cyclin-dependent kinase 2 Cdc2 C00025629 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00026130 1 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00026130 0 / 0
P39748 Flap endonuclease 1 Enzyme C00026130 0 / 0
O75496 Geminin Unclassified protein C00026130 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00026130 7 / 3
Q9Y253 DNA polymerase eta Enzyme C00026130 1 / 1
Q99816 Tumor susceptibility gene 101 protein Unclassified protein C00026130 0 / 0
P00734 Prothrombin S1A C00025629 4 / 2
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00026130 2 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00025765 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00025629 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00026048 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00026130 0 / 0
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor C00026130 1 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00026130 4 / 3
B2RXH2 Lysine-specific demethylase 4E Enzyme C00026130 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00026130 0 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00026130 0 / 0
O00255 Menin Unclassified protein C00026130 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00026130 1 / 2
Q9UBT2 SUMO-activating enzyme subunit 2 Enzyme C00026130 0 / 0
Q9UBE0 SUMO-activating enzyme subunit 1 Unclassified protein C00026130 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (38)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#119900 Digital clubbing, isolated congenital P15428
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600274 Frontotemporal dementia; ftd P10636
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#166350 Osseous heteroplasia, progressive; poh P63092
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#275210 Restrictive dermopathy, lethal P02545
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#601367 Stroke, ischemic P00734
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (30)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)