Species

KNApSAcK Entry

Organism name Stephania mashanica H.S.Lo.et.B.N.Chang
Genus Stephania
Family Menispermaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Stephania
Linked NCBI taxonomy ID 147243
Linked level genus

Family

Family in NCBI taxonomy Menispermaceae
ID 3455

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (4)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00025607 External link 512 NSC 251699
/ L-Dicentrine
/ (-)-Dicentrine
/ (R)-(-)-Dicentrine
CHEMBL464748
CHEMBL478754
15 / 20 / 16 No. 20 No. 4
C00025632 External link 512 Isocorypalmine
/ (-)-Isocorypalmine
/ Tetrahydrocolumbamine
/ O10-Methylstepholidine
CHEMBL2334891
CHEMBL2334892
4 / 3 / 0 No. 37 No. 4
C00025849 External link 512 Dicentrinone
/ Oxodicentrine
CHEMBL463284
1 / 0 / 0 No. 74
C00025629 External link 512 Sinoacutine
/ (-)-Sinoacutine
/ (-)-Salutaridine
CHEMBL402782
CHEMBL404097
3 / 4 / 2 No. 426 No. 4

Human Protein / Gene in interactions

22 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P24941 Cyclin-dependent kinase 2 Cdc2 C00025607 C00025629 0 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00025632 0 / 0
P02545 Prelamin-A/C Unclassified protein C00025607 11 / 10
P21728 D(1A) dopamine receptor Dopamine receptor C00025632 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00025607 1 / 0
P11387 DNA topoisomerase 1 Isomerase C00025849 0 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00025632 2 / 0
P39748 Flap endonuclease 1 Enzyme C00025607 0 / 0
O75496 Geminin Unclassified protein C00025607 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00025607 1 / 2
P00734 Prothrombin S1A C00025629 4 / 2
P06746 DNA polymerase beta Enzyme C00025607 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00025629 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00025607 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00025607 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00025607 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00025607 0 / 0
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00025632 1 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00025607 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00025607 1 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00025607 2 / 1
P43351 DNA repair protein RAD52 homolog Unclassified protein C00025607 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (27)

OMIM preferred title UniProt
#103780 Alcohol dependence P14416
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc Q14191
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#260540 Parkinson-dementia syndrome P10636
#614674 Periodic fever, menstrual cycle-dependent P08908
#172700 Pick disease of brain P10636
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#275210 Restrictive dermopathy, lethal P02545
#601367 Stroke, ischemic P00734
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#277700 Werner syndrome; wrn Q14191

KEGG DISEASE (18)

KEGG name UniProt
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00296 Defects in RecQ helicases Q14191 (related)