Species

KNApSAcK Entry

Organism name Perilla frutescens
Genus Perilla
Family Labiatae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Perilla frutescens
Linked NCBI taxonomy ID 48386
Linked level species

Family

Family in NCBI taxonomy Lamiaceae
ID 4136

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Natural Activity

List (37)

Species Activity
Perilla frutescens (L.) Britton Aldose-Reductase-Inhibitor
Perilla frutescens (L.) Britton Allergenic
Perilla frutescens (L.) Britton Analgesic
Perilla frutescens (L.) Britton Antibacterial
Perilla frutescens (L.) Britton Anticancer
Perilla frutescens (L.) Britton Antidote
Perilla frutescens (L.) Britton Antidote, crab
Perilla frutescens (L.) Britton Antidote, fish
Perilla frutescens (L.) Britton Antimelanomic
Perilla frutescens (L.) Britton Antinephrotic
Perilla frutescens (L.) Britton Antioxidant
Perilla frutescens (L.) Britton Antiproliferant
Perilla frutescens (L.) Britton Antipyretic
Perilla frutescens (L.) Britton Antiseptic
Perilla frutescens (L.) Britton Antispasmodic
Perilla frutescens (L.) Britton Antitussive
Perilla frutescens (L.) Britton Antiulcer
Perilla frutescens (L.) Britton Carminative
Perilla frutescens (L.) Britton Cyanogenic
Perilla frutescens (L.) Britton Cytotoxic
Perilla frutescens (L.) Britton Diaphoretic
Perilla frutescens (L.) Britton Diuretic
Perilla frutescens (L.) Britton Emollient
Perilla frutescens (L.) Britton Expectorant
Perilla frutescens (L.) Britton Fungicide
Perilla frutescens (L.) Britton Hypocholesterolemic
Perilla frutescens (L.) Britton Hypotensive
Perilla frutescens (L.) Britton Hypotriglyceridemic
Perilla frutescens (L.) Britton Immunostimulant
Perilla frutescens (L.) Britton Lipolytic
Perilla frutescens (L.) Britton Pectoral
Perilla frutescens (L.) Britton Peristaltic
Perilla frutescens (L.) Britton Piscicide
Perilla frutescens (L.) Britton Poison
Perilla frutescens (L.) Britton Sedative
Perilla frutescens (L.) Britton Stomachic
Perilla frutescens (L.) Britton Tonic

Metabolite list (11)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00006826 External link 512 Cyanidin 3-(6''-ferulylglucoside)-5-(6'''-malonylglucoside)
No. 7 No. 15
C00006823 External link 512 Cyanidin 3-(6''-ferulylglucoside)-5-glucoside
No. 7 No. 15
C00006819 External link 512 Perillanin
/ Cyanidin 3-(6-p-coumaroylglucoside)-5-glucoside
No. 7 No. 15
C00004173 External link 512 Apigenin 7-(6''-E-Caffeoylglucoside)
/ 7-[[6-O-[3-(3,4-Dihydroxyphenyl)-1-oxo-2-propenyl]-beta-D-glucopyranosyl]oxy]-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
No. 30 No. 15
C00001437 External link 512 Amygdalin
/ (R)-Amygdalin
CHEMBL515712
CHEMBL461727
CHEMBL1967951
CHEMBL2007233
D000678
92 / 37 / 31 No. 128 No. 72
C00011414 External link 512 (E,E,E)-3,7,11-trimethyl-2,4,6,10-Dodecatetraene
No. 404 No. 38
C00011415 External link 512 (E,E,Z)-3,7,11-trimethyl-2,4,6,10-Dodecatetraene
No. 404 No. 38
C00000803 External link 512 (-)-Limonene
CHEMBL15799
CHEMBL449062
7 / 21 / 48 No. 848 No. 35
C00010319 External link 512 Perilla ketone
/ 1-(3-Furanyl)-4-methyl-1-pentanone
CHEMBL469753
C015426
1 / 1 / 0 No. 3100
C00010313 External link 512 Egomaketone
/ 3-Penten-1-one
No. 6959
C00010328 External link 512 Isoegomaketone
No. 7207

Human Protein / Gene in interactions

99 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000803 C00001437 0 / 3
P28482 Mitogen-activated protein kinase 1 Erk C00001437 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00001437 0 / 0
P27338 Amine oxidase [flavin-containing] B Oxidoreductase C00001437 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001437 1 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00001437 2 / 2
P08246 Neutrophil elastase S1A C00001437 2 / 1
P33765 Adenosine receptor A3 Adenosine receptor C00001437 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00001437 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00001437 0 / 0
P29466 Caspase-1 C14 C00001437 0 / 0
P17252 Protein kinase C alpha type Alpha C00001437 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00001437 0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00000803 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00001437 2 / 2
P02545 Prelamin-A/C Unclassified protein C00000803 11 / 10
P10828 Thyroid hormone receptor beta NR1A2 C00000803 3 / 1
P19793 Retinoic acid receptor RXR-alpha NR2B1 C00000803 0 / 0
P00918 Carbonic anhydrase 2 Lyase C00001437 1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00001437 0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00001437 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00001437 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00001437 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00001437 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00001437 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00001437 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00001437 0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00001437 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00001437 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00001437 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001437 0 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00001437 1 / 8
P14416 D(2) dopamine receptor Dopamine receptor C00001437 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00001437 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00001437 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00001437 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00001437 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00001437 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00001437 0 / 0
P01730 T-cell surface glycoprotein CD4 Surface antigen C00001437 1 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00001437 1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00001437 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00001437 1 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00001437 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00001437 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00001437 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00001437 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00001437 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00001437 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00001437 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00001437 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00001437 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00001437 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00001437 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00001437 1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00001437 0 / 0
P08311 Cathepsin G S1A C00001437 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00001437 1 / 0
P03956 Interstitial collagenase M10A C00001437 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00001437 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00001437 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00001437 0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00001437 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00001437 0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00001437 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00001437 2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00001437 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00001437 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00001437 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00001437 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00001437 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00001437 0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00001437 1 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00000803 7 / 37
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00001437 2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001437 0 / 0
O75762 Transient receptor potential cation channel subfamily A member 1 Unclassified protein C00010319 1 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00001437 0 / 0
P03372 Estrogen receptor NR3A1 C00001437 1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00001437 1 / 0
P22303 Acetylcholinesterase Hydrolase C00001437 1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00001437 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00001437 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00001437 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00001437 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00001437 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00001437 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00001437 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001437 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001437 0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00001437 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00000803 0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00001437 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00001437 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00001437 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00001437 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00001437 1 / 1
P06239 Tyrosine-protein kinase Lck Src C00001437 0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00001437 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (58)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615040 Episodic pain syndrome, familial, 1; feps1 O75762
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 P04626
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#603932 Intervertebral disc disease; idd P14780
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
P04637
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#613949 Okt4 epitope deficiency P01730
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#260500 Papilloma of choroid plexus; cpp P04637
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#190300 Tremor, hereditary essential, 1; etm1 P35462
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (65)

KEGG name UniProt
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
P04637 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
P04637 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
P04637 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
P04637 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04626 (related)
P04637 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
P04637 (related)
H00046 Cholangiocarcinoma P04626 (related)
P04637 (related)
P35354 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P14780 (related)
P35354 (related)
H00029 Vulvar cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00033 Adrenal carcinoma P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00044 Cancer of the anal canal P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H01205 Coumarin resistance P11712 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)