Broussonetia kazinoki
Species
KNApSAcK Entry
| Organism name | Broussonetia kazinoki |
|---|---|
| Genus | Broussonetia |
| Family | Moraceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Broussonetia kazinoki |
|---|---|
| Linked NCBI taxonomy ID | 66380 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Moraceae |
|---|---|
| ID | 3487 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (30)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00019064
|
Oleanolic acid
/ Astrantiagenin C / Virgaureagenin B / 3beta-Hydroxyolean-12-en-28-oic acid |
CHEMBL56615
CHEMBL168 CHEMBL180553 CHEMBL365375 CHEMBL486382 CHEMBL1413646 CHEMBL1436454 |
D009828
|
30 / 8 / 12 | 21 / 15 | No. 13 | No. 51 |
|
|
C00013523
|
Broussonol D
/ 2-[3,4-Dihydroxy-5-(3-methyl-2-butenyl)phenyl]-3,5,7-trihydroxy-8-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one |
CHEMBL458762
|
No. 14 | No. 15 |
|
|||
|
C00013522
|
Broussonol E
/ Papyriflavonol A / 2-[3,4-Dihydroxy-5-(3-methyl-2-butenyl)phenyl]-3,5,7-trihydroxy-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one |
CHEMBL457303
|
No. 14 | No. 15 |
|
|||
|
C00013538
|
Broussonol A
/ 8-(1,1-Dimethyl-2-propenyl)-3,5,7-trihydroxy-2-(8-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-4H-1-benzopyran-4-one |
CHEMBL457085
|
No. 18 | No. 15 |
|
|||
|
C00013536
|
Broussonol B
/ 8,9-Dihydro-3,5-dihydroxy-2-(8-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-8,9,9-trimethyl-4H-furo[2,3-h]-1-benzopyran-4-one |
CHEMBL457086
|
No. 18 | No. 15 |
|
|||
|
C00013535
|
Broussonol C
/ 2-[3,4-Dihydroxy-5-(3-methyl-2-butenyl)phenyl]-8,9-dihydro-3,5-dihydroxy-8,9,9-trimethyl-4H-furo[2,3-h]-1-benzopyran-4-one |
CHEMBL458761
|
No. 47 | No. 15 |
|
|||
|
C00000950
|
Cassiaflavan
/ 7,4'-Dihydroxyflavan |
CHEMBL508033
CHEMBL463804 CHEMBL463168 |
4 / 3 / 3 | No. 179 | No. 15 |
|
||
|
C00027960
|
Broussonetine C
|
CHEMBL1373221
|
4 / 7 / 5 | No. 514 |
|
|||
|
C00027970
|
Broussonetinine A
|
CHEMBL1373221
|
4 / 7 / 5 | No. 514 |
|
|||
|
C00027971
|
Broussonetinine B
|
No. 514 |
|
|||||
|
C00027962
|
Broussonetine E
|
CHEMBL470659
|
No. 514 |
|
||||
|
C00027961
|
Broussonetine D
|
No. 514 |
|
|||||
|
C00027963
|
Broussonetine F
|
CHEMBL470660
|
No. 514 |
|
||||
|
C00046059
|
Kazinol J
|
CHEMBL464845
|
No. 794 | No. 15 |
|
|||
|
C00046058
|
Kazinol F
|
CHEMBL457677
|
No. 794 | No. 15 |
|
|||
|
C00027959
|
Broussonetine B
|
CHEMBL1589138
|
5 / 4 / 1 | No. 1088 |
|
|||
|
C00027958
|
Broussonetine A
|
No. 1088 |
|
|||||
|
C00027968
|
Broussonetine K
|
CHEMBL513394
|
No. 1088 |
|
||||
|
C00027969
|
Broussonetine L
|
CHEMBL469427
|
No. 1088 |
|
||||
|
C00049049
|
Kazinol R
|
CHEMBL454051
|
No. 1730 |
|
||||
|
C00049047
|
Kazinol D
|
CHEMBL454305
|
No. 1730 |
|
||||
|
C00049048
|
Kazinol K
|
CHEMBL454306
|
No. 1730 |
|
||||
|
C00013247
|
Kazinol Q
/ (+)-4-[6-(1,1-Dimethyl-2-propenyl)-3,4-dihydro-7-hydroxy-2H-1-benzopyran-2-yl]-3,6-bis(3-methyl-2-butenyl)-1,2-benzenediol |
CHEMBL453275
|
No. 1730 |
|
||||
|
C00008788
|
Kazinol H
|
No. 1730 |
|
|||||
|
C00008789
|
Kazinol E
|
No. 1730 |
|
|||||
|
C00027966
|
Broussonetine I
|
No. 3838 |
|
|||||
|
C00027967
|
Broussonetine J
|
No. 3838 |
|
|||||
|
C00027964
|
Broussonetine G
|
CHEMBL470661
|
No. 5257 |
|
||||
|
C00027965
|
Broussonetine H
|
CHEMBL470868
|
No. 5257 |
|
||||
|
C00028848
|
Plakoridine A
|
No. 6085 |
|
Human Protein / Gene in interactions
37 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00019064 C00027960 C00027970 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00027959 C00027960 C00027970 | 0 / 0 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00000950 C00019064 | 2 / 2 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00019064 C00027959 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00019064 C00027959 | 0 / 0 |
| P04062 | Glucosylceramidase | Enzyme | C00027960 C00027970 | 6 / 4 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00027960 C00027970 | 1 / 1 |
| P06746 | DNA polymerase beta | Enzyme | C00019064 C00027959 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00019064 | 0 / 0 |
| Q8TDU6 | G-protein coupled bile acid receptor 1 | Steroid-like ligand receptor | C00019064 | 0 / 0 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00019064 | 0 / 0 |
| P51452 | Dual specificity protein phosphatase 3 | Ser_Thr_Tyr | C00019064 | 0 / 0 |
| P10586 | Receptor-type tyrosine-protein phosphatase F | Receptor tyrosine-protein phosphatase | C00019064 | 0 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00019064 | 0 / 0 |
| P14555 | Phospholipase A2, membrane associated | Enzyme | C00000950 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00019064 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00019064 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00000950 | 0 / 1 |
| P24666 | Low molecular weight phosphotyrosine protein phosphatase | Tyr | C00019064 | 0 / 0 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00019064 | 0 / 0 |
| Q06124 | Tyrosine-protein phosphatase non-receptor type 11 | Tyr | C00019064 | 4 / 2 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00019064 | 0 / 0 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00019064 | 0 / 0 |
| P18433 | Receptor-type tyrosine-protein phosphatase alpha | Receptor tyrosine-protein phosphatase | C00019064 | 0 / 0 |
| P35236 | Tyrosine-protein phosphatase non-receptor type 7 | Tyr | C00019064 | 0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00019064 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00000950 | 1 / 1 |
| P35228 | Nitric oxide synthase, inducible | Enzyme | C00019064 | 1 / 1 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00019064 | 0 / 3 |
| O60218 | Aldo-keto reductase family 1 member B10 | Enzyme | C00019064 | 0 / 0 |
| P17706 | Tyrosine-protein phosphatase non-receptor type 2 | Tyr | C00019064 | 0 / 1 |
| P29350 | Tyrosine-protein phosphatase non-receptor type 6 | Tyr | C00019064 | 0 / 0 |
| P04054 | Phospholipase A2 | Enzyme | C00019064 | 0 / 0 |
| P23469 | Receptor-type tyrosine-protein phosphatase epsilon | Receptor tyrosine-protein phosphatase | C00019064 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00027959 | 4 / 1 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00019064 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00019064 | 1 / 4 |
21 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 177 | AGER, RAGE | advanced glycosylation end product-specific receptor |
C00019064
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00019064
|
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00019064
|
| 847 | CAT | catalase (EC:1.11.1.6) |
C00019064
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00019064
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00019064
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00019064
|
| 3065 | HDAC1, GON-10, HD1, RPD3, RPD3L1 | histone deacetylase 1 (EC:3.5.1.98) |
C00019064
|
| 3146 | HMGB1, HMG1, HMG3, SBP-1 | high mobility group box 1 |
C00019064
|
| 3383 | ICAM1, BB2, CD54, P3.58 | intercellular adhesion molecule 1 |
C00019064
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00019064
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00019064
|
| 4233 | MET, AUTS9, HGFR, RCCP2, c-Met | met proto-oncogene (EC:2.7.10.1) |
C00019064
|
| 4780 | NFE2L2, NRF2 | nuclear factor, erythroid 2-like 2 |
C00019064
|
| 5052 | PRDX1, MSP23, NKEF-A, NKEFA, PAG, PAGA, PAGB, PRX1, PRXI, TDPX2 | peroxiredoxin 1 (EC:1.11.1.15) |
C00019064
|
| 5728 | PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1 | phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) |
C00019064
|
| 6401 | SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2 | selectin E |
C00019064
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00019064
|
| 7150 | TOP1, TOPI | topoisomerase (DNA) I (EC:5.99.1.2) |
C00019064
|
| 7153 | TOP2A, TOP2, TP2A | topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) |
C00019064
|
| 7412 | VCAM1, CD106, INCAM-100 | vascular cell adhesion molecule 1 |
C00019064
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (20)
| OMIM | preferred title | UniProt |
|---|---|---|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #607785 | Juvenile myelomonocytic leukemia; jmml |
Q06124
|
| #151100 | Leopard syndrome 1 |
Q06124
|
| #611162 | Malaria, susceptibility to |
P35228
|
| #156250 | Metachondromatosis; metcds |
Q06124
|
| #163950 | Noonan syndrome 1; ns1 |
Q06124
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
KEGG DISEASE (19)
| KEGG | name | UniProt |
|---|---|---|
| H00026 | Endometrial Cancer |
P03372
(marker)
Q92731 (marker) |
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P11511
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H00408 | Type I diabetes mellitus |
P17706
(related)
|
| H00017 | Esophageal cancer |
P35228
(related)
P35354 (related) |
| H00025 | Penile cancer |
P35354
(related)
|
| H00046 | Cholangiocarcinoma |
P35354
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00523 | Noonan syndrome and related disorders |
Q06124
(related)
|
| H01018 | Metachondromatosis |
Q06124
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
Diseases related to CTD interactions
15 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D002252 | Carbon Tetrachloride Poisoning |
C00019064
|
| D056486 | Drug-Induced Liver Injury |
C00019064
|
| D050171 | Dyslipidemias |
C00019064
|
| D018149 | Glucose Intolerance |
C00019064
|
| D006949 | Hyperlipidemias |
C00019064
|
| D007249 | Inflammation |
C00019064
|
| D007674 | Kidney Diseases |
C00019064
|
| D008103 | Liver Cirrhosis |
C00019064
|
| D008106 | Liver Cirrhosis, Experimental |
C00019064
|
| D008107 | Liver Diseases |
C00019064
|
| D017202 | Myocardial Ischemia |
C00019064
|
| D009369 | Neoplasms |
C00019064
|
| D009765 | Obesity |
C00019064
|
| D011041 | Poisoning |
C00019064
|
| D011230 | Precancerous Conditions |
C00019064
|