Gentiana loureirii

• Index
• Plant Species
• Metabolite list (6)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Gentiana loureirii
Genus	Gentiana
Family	Gentianaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Gentiana
Linked NCBI taxonomy ID	21496
Linked level	genus

Family

Family in NCBI taxonomy	Gentianaceae
ID	21472

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	asterids
ID	71274

Metabolite list (6)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00001017	Cosmosiin / Apigenin 7-glucoside / (-)-Apigenin 7-glucoside / Apigenin 7-O-beta-D-glucopyranoside	CHEMBL487995 CHEMBL487017 CHEMBL1591566 CHEMBL2165585	C057792	5 / 6 / 1		No. 2	No. 15
C00019064	Oleanolic acid / Astrantiagenin C / Virgaureagenin B / 3beta-Hydroxyolean-12-en-28-oic acid	CHEMBL56615 CHEMBL168 CHEMBL180553 CHEMBL365375 CHEMBL486382 CHEMBL1413646 CHEMBL1436454	D009828	30 / 8 / 12	21 / 15	No. 13	No. 51
C00001055	Isoorientin / Homoorientin / Lespecapitioside / Luteolin 6-C-beta-D-glucopyranoside / 2-(3,4-Dihydroxyphenyl)-6-beta-D-glucopyranosyl-5,7-dihydroxy-4H-1-benzopyran-4-one	CHEMBL239559 CHEMBL1302308	C057912	23 / 14 / 17	0 / 1	No. 22	No. 15
C00003088	Loganin	CHEMBL1081584 CHEMBL1081586 CHEMBL1589904 CHEMBL2135791	C059516	2 / 1 / 1	0 / 1	No. 56	No. 36
C00010604	Loganic acid	CHEMBL1081585 CHEMBL1079678 CHEMBL1356464 CHEMBL1452775	C002947	6 / 8 / 7		No. 64	No. 36
C00010794	Sweroside	CHEMBL456137	C049412	1 / 0 / 0		No. 806	No. 36

Human Protein / Gene in interactions

56 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P06746	DNA polymerase beta	Enzyme	C00001055 C00019064	0 / 0
Q01196	Runt-related transcription factor 1	Unclassified protein	C00001055 C00019064	1 / 4
Q13951	Core-binding factor subunit beta	Unclassified protein	C00001055 C00019064	0 / 1
Q9UBT6	DNA polymerase kappa	Enzyme	C00001017 C00001055	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00001055 C00010604	4 / 3
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00001055 C00019064	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00001055 C00019064	0 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00001055 C00019064	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00001017 C00019064	0 / 0
O75496	Geminin	Unclassified protein	C00003088 C00019064	0 / 0
P60033	CD81 antigen	Unclassified protein	C00003088 C00010604	1 / 1
Q96RI1	Bile acid receptor	NR1H4	C00019064	0 / 0
P51452	Dual specificity protein phosphatase 3	Ser_Thr_Tyr	C00019064	0 / 0
P10586	Receptor-type tyrosine-protein phosphatase F	Receptor tyrosine-protein phosphatase	C00019064	0 / 0
Q9NR56	Muscleblind-like protein 1	Unclassified protein	C00001055	1 / 0
Q8TDU6	G-protein coupled bile acid receptor 1	Steroid-like ligand receptor	C00019064	0 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00019064	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00001055	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00019064	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00010604	2 / 0
P24666	Low molecular weight phosphotyrosine protein phosphatase	Tyr	C00019064	0 / 0
P15121	Aldose reductase	Enzyme	C00019064	0 / 0
P49841	Glycogen synthase kinase-3 beta	Gsk	C00019064	0 / 0
Q9Y253	DNA polymerase eta	Enzyme	C00001055	1 / 1
Q9Y468	Lethal(3)malignant brain tumor-like protein 1	Unclassified protein	C00001055	0 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00001055	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00001017	0 / 0
P11511	Cytochrome P450 19A1	Cytochrome P450 19A1	C00019064	2 / 2
O75604	Ubiquitin carboxyl-terminal hydrolase 2	Enzyme	C00019064	0 / 0
P18433	Receptor-type tyrosine-protein phosphatase alpha	Receptor tyrosine-protein phosphatase	C00019064	0 / 0
P35236	Tyrosine-protein phosphatase non-receptor type 7	Tyr	C00019064	0 / 0
Q9UNQ0	ATP-binding cassette sub-family G member 2	ATP binding cassette	C00001017	2 / 0
Q06124	Tyrosine-protein phosphatase non-receptor type 11	Tyr	C00019064	4 / 2
P35228	Nitric oxide synthase, inducible	Enzyme	C00019064	1 / 1
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00001055	1 / 1
O75164	Lysine-specific demethylase 4A	Enzyme	C00001055	0 / 0
P18031	Tyrosine-protein phosphatase non-receptor type 1	Tyr	C00019064	0 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00019064	0 / 3
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00010604	0 / 0
P17706	Tyrosine-protein phosphatase non-receptor type 2	Tyr	C00019064	0 / 1
P07900	Heat shock protein HSP 90-alpha	Other cytosolic protein	C00010794	0 / 0
P29350	Tyrosine-protein phosphatase non-receptor type 6	Tyr	C00019064	0 / 0
P04054	Phospholipase A2	Enzyme	C00019064	0 / 0
P23469	Receptor-type tyrosine-protein phosphatase epsilon	Receptor tyrosine-protein phosphatase	C00019064	0 / 0
O60218	Aldo-keto reductase family 1 member B10	Enzyme	C00019064	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00001055	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00001055	1 / 1
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00010604	1 / 0
O00255	Menin	Unclassified protein	C00001055	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00001055	1 / 2
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00001055	0 / 0
Q16637	Survival motor neuron protein	Unclassified protein	C00001017	4 / 1
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00001055	0 / 0
P01215	Glycoprotein hormones alpha chain	Unclassified protein	C00010604	0 / 3
Q9H0H5	Rac GTPase-activating protein 1	Unclassified protein	C00001055	0 / 0
Q14191	Werner syndrome ATP-dependent helicase	Enzyme	C00001055	2 / 1

21 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
177	AGER, RAGE	advanced glycosylation end product-specific receptor	C00019064
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00019064
841	CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5	caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)	C00019064
847	CAT	catalase (EC:1.11.1.6)	C00019064
595	CCND1, BCL1, D11S287E, PRAD1, U21B31	cyclin D1	C00019064
1544	CYP1A2, CP12, P3-450, P450(PA)	cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1)	C00019064
1576	CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	C00019064
3065	HDAC1, GON-10, HD1, RPD3, RPD3L1	histone deacetylase 1 (EC:3.5.1.98)	C00019064
3146	HMGB1, HMG1, HMG3, SBP-1	high mobility group box 1	C00019064
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00019064
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00019064
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00019064
4233	MET, AUTS9, HGFR, RCCP2, c-Met	met proto-oncogene (EC:2.7.10.1)	C00019064
4780	NFE2L2, NRF2	nuclear factor, erythroid 2-like 2	C00019064
5052	PRDX1, MSP23, NKEF-A, NKEFA, PAG, PAGA, PAGB, PRX1, PRXI, TDPX2	peroxiredoxin 1 (EC:1.11.1.15)	C00019064
5728	PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1	phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48)	C00019064
6401	SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2	selectin E	C00019064
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00019064
7150	TOP1, TOPI	topoisomerase (DNA) I (EC:5.99.1.2)	C00019064
7153	TOP2A, TOP2, TP2A	topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3)	C00019064
7412	VCAM1, CD106, INCAM-100	vascular cell adhesion molecule 1	C00019064

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions