Citrus hassaku
Species
KNApSAcK Entry
| Organism name | Citrus hassaku |
|---|---|
| Genus | Citrus |
| Family | Rutaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Citrus hassaku |
|---|---|
| Linked NCBI taxonomy ID | 488171 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Rutaceae |
|---|---|
| ID | 23513 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (25)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00001076
|
Nobiletin
/ 3',4',5,6,7,8-Hexamethoxyflavone |
CHEMBL76447
|
C008661
|
22 / 23 / 20 | 5 / 2 | No. 8 | No. 15 |
|
|
C00003912
|
Isosinensetin
/ 6-Demethoxynobiletin / 5,7,8,3',4'-Pentamethoxyflavone / 2-(3,4-Dimethoxyphenyl)-5,7,8-trimethoxy-4H-1-benzopyran-4-one |
CHEMBL451707
|
No. 8 | No. 15 |
|
|||
|
C00004745
|
Gossypetin hexamethyl ether
/ 3,5,7,8,3',4'-Hexamethoxyflavone / 2-(3,4-Dimethoxyphenyl)-3,5,7,8-tetramethoxy-4H-1-benzopyran-4-one |
No. 8 | No. 15 |
|
||||
|
C00004803
|
Natsudaidain
/ 3-Hydroxy-3',4',5,6,7,8-hexamethoxyflavone / 2-(3,4-Dimethoxyphenyl)-3-hydroxy-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one |
CHEMBL225702
|
C092904
|
No. 8 | No. 15 |
|
||
|
C00013304
|
6-Demethoxytangeritin
/ 6-Demethoxytangeretin / 4',5,7,8-Tetramethoxyflavone / Tetra-O-methylisoscutellarein / 5,7,8-Trimethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one |
CHEMBL556454
|
No. 8 | No. 15 |
|
|||
|
C00004804
|
3,3',4',5,6,7,8-Heptamethoxyflavone
/ 3,5,6,7,8,3',4'-Heptamethoxyflavone / 2-(3,4-Dimethoxyphenyl)-3,5,6,7,8-pentamethoxy-4H-1-benzopyran-4-one |
CHEMBL77993
|
C059294
|
17 / 10 / 2 | No. 8 | No. 15 |
|
|
|
C00019896
|
7-(6R-Hydroxy-3,7-dimethylocta-2,5-dienyl)-7-hydroxycoumarin
|
CHEMBL2346911
|
No. 335 |
|
||||
|
C00020024
|
Seselinol
|
No. 750 | No. 25 |
|
||||
|
C00019989
|
Oxanordentatin
|
No. 953 |
|
|||||
|
C00019816
|
Citrumarin B
|
No. 1162 |
|
|||||
|
C00019817
|
Citrumarin C
|
No. 1162 |
|
|||||
|
C00019815
|
Citrumarin A
|
No. 1162 |
|
|||||
|
C00019942
|
Khelmarin C
|
No. 1162 |
|
|||||
|
C00019800
|
Bisnorponcitrin
|
No. 1162 |
|
|||||
|
C00019940
|
Khelmarin A
|
No. 1162 |
|
|||||
|
C00019984
|
Nordenletin
|
No. 1162 |
|
|||||
|
C00019982
|
Neoacrimarine C
|
No. 1324 |
|
|||||
|
C00019932
|
(+/-)-7-Hydroxy-6-linalycoumarin
|
No. 1758 | No. 25 |
|
||||
|
C00020025
|
Seselinol isovalerate
|
No. 1945 |
|
|||||
|
C00019988
|
Oxaclausarin
|
No. 2171 |
|
|||||
|
C00019983
|
Neoacrimarine D
|
No. 2497 |
|
|||||
|
C00019799
|
Bishassanidin
|
No. 4398 |
|
|||||
|
C00019823
|
Claudimerin A
|
No. 4398 |
|
|||||
|
C00019887
|
Hassmarin
|
No. 4863 |
|
|||||
|
C00019931
|
(R)-6-O-(4-Geranyloxy-2-hydroxy)-cinnamoylmarmin
|
No. 7646 |
|
Human Protein / Gene in interactions
37 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P08183 | Multidrug resistance protein 1 | drug | C00001076 C00004804 | 1 / 0 |
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | C00001076 C00004804 | 2 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00001076 | 0 / 0 |
| O94956 | Solute carrier organic anion transporter family member 2B1 | Unclassified protein | C00001076 | 0 / 0 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00001076 | 1 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001076 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00001076 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00001076 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00001076 | 0 / 0 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00001076 | 5 / 3 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00001076 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00001076 | 3 / 3 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00001076 | 0 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00001076 | 2 / 2 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00001076 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001076 | 0 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00001076 | 4 / 3 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00001076 | 0 / 0 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00001076 | 1 / 1 |
| O00255 | Menin | Unclassified protein | C00001076 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001076 | 1 / 2 |
| Q13748 | Tubulin alpha-3C/D chain | Structural | C00004804 | 0 / 0 |
| P68366 | Tubulin alpha-4A chain | Structural | C00004804 | 0 / 0 |
| Q9H4B7 | Tubulin beta-1 chain | Structural | C00004804 | 1 / 0 |
| P04350 | Tubulin beta-4A chain | Structural | C00004804 | 2 / 0 |
| Q3ZCM7 | Tubulin beta-8 chain | Structural | C00004804 | 0 / 0 |
| P07437 | Tubulin beta chain | Structural | C00004804 | 0 / 0 |
| Q71U36 | Tubulin alpha-1A chain | Structural | C00004804 | 1 / 1 |
| P68371 | Tubulin beta-4B chain | Structural | C00004804 | 0 / 0 |
| Q13509 | Tubulin beta-3 chain | Structural | C00004804 | 2 / 1 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00001076 | 1 / 1 |
| P68363 | Tubulin alpha-1B chain | Unclassified protein | C00004804 | 0 / 0 |
| Q13885 | Tubulin beta-2A chain | Structural | C00004804 | 0 / 0 |
| Q6PEY2 | Tubulin alpha-3E chain | Unclassified protein | C00004804 | 0 / 0 |
| Q9BQE3 | Tubulin alpha-1C chain | Unclassified protein | C00004804 | 0 / 0 |
| Q9BUF5 | Tubulin beta-6 chain | Structural | C00004804 | 0 / 0 |
| Q9BVA1 | Tubulin beta-2B chain | Structural | C00004804 | 1 / 0 |
5 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 972 | CD74, DHLAG, HLADG, II, Ia-GAMMA | CD74 molecule, major histocompatibility complex, class II invariant chain |
C00001076
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00001076
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00001076
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00001076
|
| 4316 | MMP7, MMP-7, MPSL1, PUMP-1 | matrix metallopeptidase 7 (matrilysin, uterine) (EC:3.4.24.23) |
C00001076
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (30)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #614490 | Blood group, junior system; jr |
Q9UNQ0
|
| %606641 | Body mass index; bmi |
P37231
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #614039 | Cortical dysplasia, complex, with other brain malformations 1; cdcbm1 |
Q13509
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #128101 | Dystonia 4, torsion, autosomal dominant; dyt4 |
P04350
|
| #600638 | Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement; cfeom3a |
Q13509
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #137800 | Glioma susceptibility 1; glm1 |
P37231
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #612438 | Leukodystrophy, hypomyelinating, 6; hld6 |
P04350
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #611603 | Lissencephaly 3; lis3 |
Q71U36
|
| #613112 | Macrothrombocytopenia, autosomal dominant, tubb1-related |
Q9H4B7
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #601665 | Obesity |
P37231
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #610031 | Polymicrogyria, symmetric or asymmetric; pmgysa |
Q9BVA1
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 |
Q9UNQ0
|
| #278300 | Xanthinuria, type i |
P47989
|
KEGG DISEASE (22)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
Q13148 (related) |
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00032 | Thyroid cancer |
P37231
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P37231
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00838 | Congenital fibrosis of the extraocular muscles (CFEOM) |
Q13509
(related)
|
| H00268 | Lissencephaly (LIS) |
Q71U36
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|