Garcinia xanthochymus
Species
KNApSAcK Entry
| Organism name | Garcinia xanthochymus |
|---|---|
| Genus | Garcinia |
| Family | Clusiaceae / Clusiaceae-Guttiferae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Garcinia xanthochymus |
|---|---|
| Linked NCBI taxonomy ID | 198766 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Clusiaceae |
|---|---|
| ID | 55961 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (15)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00042217
|
Alloathyriol
|
CHEMBL482243
|
No. 3 | No. 15 |
|
|||
|
C00031806
|
Garciniaxanthone E
|
No. 14 | No. 15 |
|
||||
|
C00001110
|
Vitexin
/ Apigenin 8-C-glucoside / 8-D-Glucosyl-4',5,7-trihydroxyflavone / 8-beta-D-Glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one |
CHEMBL487417
CHEMBL1332209 CHEMBL1357921 |
16 / 4 / 8 | No. 22 | No. 15 |
|
||
|
C00006431
|
3,8''-Biapigenin
|
CHEMBL515252
|
21 / 16 / 12 | No. 34 | No. 18 |
|
||
|
C00042224
|
Amenthoflavone
|
CHEMBL63354
|
50 / 39 / 29 | No. 34 | No. 18 |
|
||
|
C00006432
|
Volkensiflavone
|
CHEMBL63919
CHEMBL463023 |
No. 88 |
|
||||
|
C00033898
|
Guttiferone E
|
CHEMBL454261
CHEMBL502489 CHEMBL2087609 |
2 / 1 / 1 | No. 123 |
|
|||
|
C00042642
|
Isoxanthochymol
/ (+)-Isoxanthochymol |
CHEMBL458934
CHEMBL1077027 CHEMBL1098255 CHEMBL2087611 |
2 / 1 / 1 | No. 123 |
|
|||
|
C00042570
|
Guttiferone H
/ (+)-Guttiferone H |
CHEMBL444720
|
No. 123 |
|
||||
|
C00003023
|
Xanthochymol
|
CHEMBL454261
CHEMBL502489 CHEMBL2087609 |
C414432
|
2 / 1 / 1 | No. 123 |
|
||
|
C00042241
|
Aristophenone A
|
CHEMBL516196
|
No. 123 |
|
||||
|
C00042436
|
Cycloxanthochymol
|
CHEMBL1098252
CHEMBL1098256 |
No. 123 |
|
||||
|
C00006444
|
Xanthochymusside
|
No. 341 |
|
|||||
|
C00006437
|
Fukugeside
|
CHEMBL503951
|
No. 341 |
|
||||
|
C00042524
|
Gambogenone
/ (-)-Gambogenone |
CHEMBL480075
|
No. 8020 |
|
Human Protein / Gene in interactions
72 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q09472 | Histone acetyltransferase p300 | Enzyme | C00003023 C00033898 C00042642 | 1 / 1 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00001110 C00006431 C00042224 | 1 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00001110 C00006431 C00042224 | 0 / 0 |
| Q92831 | Histone acetyltransferase KAT2B | Enzyme | C00003023 C00033898 C00042642 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00001110 C00006431 C00042224 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00001110 C00006431 C00042224 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00001110 C00006431 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00006431 C00042224 | 4 / 3 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00001110 C00042224 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00006431 C00042224 | 0 / 0 |
| Q07820 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Other cytosolic protein | C00006431 C00042224 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001110 C00006431 | 0 / 1 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00006431 C00042224 | 2 / 1 |
| O75496 | Geminin | Unclassified protein | C00001110 C00006431 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00006431 C00042224 | 0 / 0 |
| P14867 | Gamma-aminobutyric acid receptor subunit alpha-1 | GABA-A alpha | C00042224 | 1 / 1 |
| P43235 | Cathepsin K | C1A | C00042224 | 1 / 2 |
| P47712 | Cytosolic phospholipase A2 | Enzyme | C00042224 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00042224 | 0 / 0 |
| P17405 | Sphingomyelin phosphodiesterase | Enzyme | C00042224 | 2 / 2 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00042224 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00042224 | 2 / 0 |
| P49763 | Placenta growth factor | Unclassified protein | C00042224 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00042224 | 1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00042224 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00001110 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00042224 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00042224 | 7 / 3 |
| P54132 | Bloom syndrome protein | Enzyme | C00006431 | 1 / 2 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00001110 | 0 / 0 |
| P15692 | Vascular endothelial growth factor A | Secreted protein | C00042224 | 1 / 2 |
| P56817 | Beta-secretase 1 | A1A | C00042224 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001110 | 0 / 0 |
| P08253 | 72 kDa type IV collagenase | M10A | C00042224 | 1 / 3 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00042224 | 2 / 2 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00042224 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00042224 | 0 / 0 |
| P19174 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | Enzyme | C00042224 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001110 | 1 / 1 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001110 | 0 / 1 |
| O15496 | Group 10 secretory phospholipase A2 | Enzyme | C00042224 | 0 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00042224 | 3 / 1 |
| P04062 | Glucosylceramidase | Enzyme | C00006431 | 6 / 4 |
| P06746 | DNA polymerase beta | Enzyme | C00006431 | 0 / 0 |
| P14618 | Pyruvate kinase PKM | Enzyme | C00006431 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00006431 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00006431 | 0 / 0 |
| P55072 | Transitional endoplasmic reticulum ATPase | Unclassified protein | C00042224 | 2 / 1 |
| O00255 | Menin | Unclassified protein | C00042224 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00042224 | 1 / 2 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00001110 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00001110 | 1 / 4 |
| Q9UN88 | Gamma-aminobutyric acid receptor subunit theta | GABA-A theta | C00042224 | 0 / 0 |
| P28472 | Gamma-aminobutyric acid receptor subunit beta-3 | GABA-A beta | C00042224 | 1 / 0 |
| P14555 | Phospholipase A2, membrane associated | Enzyme | C00042224 | 0 / 0 |
| P48169 | Gamma-aminobutyric acid receptor subunit alpha-4 | GABA-A alpha | C00042224 | 0 / 0 |
| O14764 | Gamma-aminobutyric acid receptor subunit delta | GABA-A delta | C00042224 | 1 / 1 |
| P31644 | Gamma-aminobutyric acid receptor subunit alpha-5 | GABA-A alpha | C00042224 | 0 / 0 |
| Q99928 | Gamma-aminobutyric acid receptor subunit gamma-3 | GABA-A gamma | C00042224 | 0 / 0 |
| P78334 | Gamma-aminobutyric acid receptor subunit epsilon | GABA-A epsilon | C00042224 | 0 / 0 |
| Q8N1C3 | Gamma-aminobutyric acid receptor subunit gamma-1 | GABA-A gamma | C00042224 | 0 / 0 |
| P34903 | Gamma-aminobutyric acid receptor subunit alpha-3 | GABA-A alpha | C00042224 | 0 / 0 |
| O00591 | Gamma-aminobutyric acid receptor subunit pi | GABA-A pi | C00042224 | 0 / 0 |
| P47870 | Gamma-aminobutyric acid receptor subunit beta-2 | GABA-A beta | C00042224 | 0 / 0 |
| P18507 | Gamma-aminobutyric acid receptor subunit gamma-2 | GABA-A gamma | C00042224 | 4 / 2 |
| P18505 | Gamma-aminobutyric acid receptor subunit beta-1 | GABA-A beta | C00042224 | 0 / 0 |
| Q16445 | Gamma-aminobutyric acid receptor subunit alpha-6 | GABA-A alpha | C00042224 | 0 / 0 |
| P47869 | Gamma-aminobutyric acid receptor subunit alpha-2 | GABA-A alpha | C00042224 | 1 / 0 |
| P63165 | Small ubiquitin-related modifier 1 | Unclassified protein | C00006431 | 1 / 1 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00006431 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001110 | 1 / 0 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00006431 | 1 / 1 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (52)
| OMIM | preferred title | UniProt |
|---|---|---|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #103780 | Alcohol dependence |
P47869
|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #613954 | Amyotrophic lateral sclerosis 14, with or without frontotemporal dementia; als14 |
P55072
|
| #210900 | Bloom syndrome; blm |
P54132
|
| #114500 | Colorectal cancer; crc |
P84022
Q14191 |
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #607208 | Dravet syndrome |
P18507
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #607681 | Epilepsy, childhood absence, susceptibility to, 2; eca2 |
P18507
|
| #612269 | Epilepsy, childhood absence, susceptibility to, 5; eca5 |
P28472
|
| #613060 | Epilepsy, idiopathic generalized, susceptibility to, 10; eig10 |
O14764
|
| #611136 | Epilepsy, juvenile myoclonic, susceptibility to, 5; ejm5 |
P14867
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #604233 | Generalized epilepsy with febrile seizures plus, type 1; gefsp1 |
P18507
|
| #611277 | Generalized epilepsy with febrile seizures plus, type 3; gefsp3 |
P18507
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #167320 | Inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 1; ibmpfd1 |
P55072
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #603933 | Microvascular complications of diabetes, susceptibility to, 1; mvcd1 |
P15692
|
| #259600 | Multicentric osteolysis, nodulosis, and arthropathy; mona |
P08253
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #257200 | Niemann-pick disease, type a |
P17405
|
| #607616 | Niemann-pick disease, type b |
P17405
|
| #613705 | Orofacial cleft 10; ofc10 |
P63165
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #265800 | Pycnodysostosis |
P43235
|
| #613684 | Rubinstein-taybi syndrome 2; rsts2 |
Q09472
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #277700 | Werner syndrome; wrn |
Q14191
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (42)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00783 | Febrile seizures |
O14764
(related)
P18507 (related) |
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00025 | Penile cancer |
P08253
(related)
|
| H00028 | Choriocarcinoma |
P08253
(related)
|
| H00472 | Torg-Winchester syndrome |
P08253
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
Q13148 (related) |
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
P55072 (related) |
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00808 | Idiopathic generalized epilepsies (IGEs) |
P14867
(related)
P18507 (related) |
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00018 | Gastric cancer |
P15692
(related)
|
| H00021 | Renal cell carcinoma |
P15692
(marker)
|
| H00137 | Niemann-Pick disease (NPD) typeA and B |
P17405
(related)
|
| H00424 | Defects in the degradation of sphingomyelin |
P17405
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00273 | Pycnodysostosis |
P43235
(related)
|
| H00425 | Lysosomal cysteine protease deficiencies |
P43235
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
Q14191 (related) |
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00516 | Isolated orofacial clefts |
P63165
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00504 | Rubinstein-Taybi syndrome |
Q09472
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|