Species

KNApSAcK Entry

Organism name Dalbergia sissoo
Genus Dalbergia
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Dalbergia sissoo
Linked NCBI taxonomy ID 107308
Linked level species

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (21)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00019129 External link 512 7-Methyltectorigenin 4'-O-[beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside]
No. 1 No. 15
C00019128 External link 512 Prunetin 4'-O-[beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside]
No. 1 No. 15
C00019127 External link 512 Tectorigenin 7-O-[beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside]
No. 1 No. 15
C00010116 External link 512 Lanceolarin
/ Biochanin A 7-O-apiosyl-(1->6)-glucoside
CHEMBL1945732
C014068
No. 1 No. 15
C00010140 External link 512 Isocaviunin 7-O-gentiobioside
No. 1 No. 15
C00010139 External link 512 Isocaviudin
/ Isocaviunin 7-O-glucoside
No. 2 No. 15
C00010118 External link 512 Trifoside
/ Prunetrin
/ Prunitrin
/ Prunitroside
/ Prunetin 4'-O-glucoside
CHEMBL1568702
6 / 5 / 3 No. 2 No. 15
C00010138 External link 512 Caviunin 7-O-glucoside
CHEMBL1945736
No. 2 No. 15
C00009489 External link 512 Isocaviunin
/ 5,7-Dihydroxy-8,2',4',5'-tetramethoxyisoflavone
No. 3 No. 15
C00009460 External link 512 Isotectorigenin
/ Pseudotectorigenin
/ 5,7,4'-Trihydroxy-8-methoxyisoflavone
CHEMBL242741
C055439
1 / 1 / 8 1 / 0 No. 3 No. 15
C00009463 External link 512 7-O-Methyltectorigenin
/ 5,4'-Dihydroxy-6,7-dimethoxyisoflavone
CHEMBL1689286
No. 3 No. 15
C00019126 External link 512 Biochanin A 7-O-[beta-D-apiofuranosyl-(1->5)-beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside]
CHEMBL1945733
No. 5 No. 15
C00006118 External link 512 Genistein 8-C-glucoside
CHEMBL1945734
CHEMBL1975213
No. 22 No. 15
C00009469 External link 512 7,4'-Di-O-methyltectorigenin
/ 5-Hydroxy-6,7,4'-trimethoxyisoflavone
No. 35 No. 15
C00010194 External link 512 Isodalbergin
/ 7-Hydroxy-6-methoxy-4-phenylcoumarin
No. 54 No. 17
C00002519 External link 512 Dalbergin
/ 6-Hydroxy-7-methoxy-4-phenylcoumarin
CHEMBL1829658
No. 54 No. 17
C00010195 External link 512 Nordalbergin
/ 6,7-Dihydroxy-4-phenylcoumarin
CHEMBL1255818
2 / 0 / 0 No. 54 No. 17
C00002897 External link 512 Pinosylvin
/ Pinosylvine
/ 3,5-Dihydroxystilbene
CHEMBL101506
CHEMBL2203685
1 / 0 / 1 No. 295 No. 13
C00001164 External link 512 Myoinositol
/ myo-Inositol
CHEMBL278373
CHEMBL468154
CHEMBL1222251
CHEMBL1231671
CHEMBL1950780
8 / 17 / 18 No. 795
C00010252 External link 512 (S)-4-Methoxydalbergione
CHEMBL255297
CHEMBL466581
CHEMBL1554531
18 / 23 / 57 No. 1327 No. 18
C00010266 External link 512 Dalbergichromene
/ 6-Hydroxy-7-methoxyneoflavene
No. 4803

Human Protein / Gene in interactions

35 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q9UNA4 DNA polymerase iota Enzyme C00001164 C00010118 0 / 0
O15118 Niemann-Pick C1 protein Unclassified protein C00010118 1 / 1
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00010252 0 / 0
P02545 Prelamin-A/C Unclassified protein C00001164 11 / 10
P16278 Beta-galactosidase Enzyme C00001164 4 / 6
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00009460 1 / 8
P11473 Vitamin D3 receptor NR1I1 C00010252 2 / 3
O15296 Arachidonate 15-lipoxygenase B Enzyme C00010252 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00010252 0 / 0
O75496 Geminin Unclassified protein C00001164 0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00010118 0 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme C00010118 4 / 2
P15121 Aldose reductase Enzyme C00010195 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00010252 0 / 0
P06280 Alpha-galactosidase A Enzyme C00001164 1 / 1
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00010252 3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00010252 2 / 2
P04637 Cellular tumor antigen p53 Transcription Factor C00010252 7 / 37
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00010118 0 / 0
Q00796 Sorbitol dehydrogenase Enzyme C00010195 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00010252 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00010252 0 / 1
P10323 Acrosin S1A C00001164 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00010252 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00010118 0 / 0
O43451 Maltase-glucoamylase, intestinal Hydrolase C00001164 0 / 0
P06239 Tyrosine-protein kinase Lck Src C00002897 0 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00010252 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00010252 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00010252 1 / 1
O00255 Menin Unclassified protein C00010252 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00010252 1 / 2
Q13951 Core-binding factor subunit beta Unclassified protein C00010252 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00010252 1 / 4
Q13148 TAR DNA-binding protein 43 Unclassified protein C00001164 1 / 1

1 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1437 CSF2, GMCSF colony stimulating factor 2 (granulocyte-macrophage) C00009460

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (45)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#119900 Digital clubbing, isolated congenital P15428
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#230500 Gm1-gangliosidosis, type i P16278
#230600 Gm1-gangliosidosis, type ii P16278
#230650 Gm1-gangliosidosis, type iii P16278
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#211980 Lung cancer P00533
P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#253010 Mucopolysaccharidosis type ivb P16278
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#257220 Niemann-pick disease, type c1; npc1 O15118
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#275210 Restrictive dermopathy, lethal P02545
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (77)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
H00018 Gastric cancer P00533 (related)
P04637 (related)
H00022 Bladder cancer P00533 (related)
P04637 (related)
H00028 Choriocarcinoma P00533 (related)
P04637 (related)
H00030 Cervical cancer P00533 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
P38398 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
P38398 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00125 Fabry disease P06280 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00123 Mucopolysaccharidosis type IV (MPS4) P16278 (related)
H00276 Galactosialidosis P16278 (related)
H00281 GM1 gangliosidosis P16278 (related)
H00421 Mucopolysaccharidosis (MPS) P16278 (related)
H00422 Glycoproteinoses P16278 (related)
H00426 Defects in the degradation of ganglioside P16278 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)