Species

KNApSAcK Entry

Organism name Cuscuta chinensis
Genus Cuscuta
Family Convolvulaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Cuscuta chinensis
Linked NCBI taxonomy ID 267557
Linked level species

Family

Family in NCBI taxonomy Convolvulaceae
ID 4118

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (11)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00007192 External link 512 (+)-Epipinoresinol
CHEMBL267963
CHEMBL487611
CHEMBL460862
7 / 5 / 6 No. 38 No. 21
C00007190 External link 512 (+)-Pinoresinol
CHEMBL267963
CHEMBL487611
CHEMBL460862
C103298
7 / 5 / 6 No. 38 No. 21
C00044036 External link 512 (11S)-Jalapinolic acid
No. 184 No. 68
C00044137 External link 512 Cuscutic acid B
/ (-)-Cuscutic acid B
No. 847
C00044136 External link 512 Cuscutic acid A
/ (-)-Cuscutic acid A
No. 847
C00044139 External link 512 Cuscutic acid D
/ (-)-Cuscutic acid D
No. 847
C00044138 External link 512 Cuscutic acid C
/ (-)-Cuscutic acid C
No. 847
C00001207 External link 512 Tiglic acid
CHEMBL55941
CHEMBL52416
No. 5138
C00044287 External link 512 Propionic acid
CHEMBL14021
C029658
3 / 0 / 0 0 / 2 No. 6558
C00044037 External link 512 (2R,3R)-Nilic acid
No. 7691
C00001176 External link 512 Acetic acid
CHEMBL539
D019342
6 / 0 / 1 5 / 14 No. 8271

Human Protein / Gene in interactions

13 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q9H0H5 Rac GTPase-activating protein 1 Unclassified protein C00007190 C00007192 0 / 0
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00007190 C00007192 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00007190 C00007192 0 / 3
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00007190 C00007192 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00001176 C00044287 0 / 0
Q9UGP5 DNA polymerase lambda Enzyme C00001176 C00044287 0 / 0
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00007190 C00007192 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00007190 C00007192 0 / 0
O15552 Free fatty acid receptor 2 Free fatty acid receptor C00001176 C00044287 0 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00007190 C00007192 5 / 3
P06239 Tyrosine-protein kinase Lck Src C00001176 0 / 1
P06241 Tyrosine-protein kinase Fyn Src C00001176 0 / 0
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein C00001176 0 / 0

5 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1571 CYP2E1, CPE1, CYP2E, P450-J, P450C2E cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) C00001176
1786 DNMT1, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT DNA (cytosine-5-)-methyltransferase 1 (EC:2.1.1.37) C00001176
2571 GAD1, CPSQ1, GAD, SCP glutamate decarboxylase 1 (brain, 67kDa) (EC:4.1.1.15) C00001176
5447 POR, CPR, CYPOR, P450R P450 (cytochrome) oxidoreductase (EC:1.6.2.4) C00001176
5649 RELN, LIS2, PRO1598, RL reelin C00001176

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (5)

OMIM preferred title UniProt
%606641 Body mass index; bmi P37231
#609338 Carotid intimal medial thickness 1 P37231
#137800 Glioma susceptibility 1; glm1 P37231
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#601665 Obesity P37231

KEGG DISEASE (7)

KEGG name UniProt
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)

Diseases related to CTD interactions

16 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D001321 Autistic Disorder C00044287
D004342 Drug Hypersensitivity C00044287
D003092 Colitis C00001176
D004195 Disease Models, Animal C00001176
D006869 Hydronephrosis C00001176
D006930 Hyperalgesia C00001176
D007249 Inflammation C00001176
D007681 Kidney Papillary Necrosis C00001176
D009069 Movement Disorders C00001176
D009336 Necrosis C00001176
D010146 Pain C00001176
D011350 Proctocolitis C00001176
D011704 Pyelonephritis C00001176
D013276 Stomach Ulcer C00001176
D014456 Ulcer C00001176
D053201 Urinary Bladder, Overactive C00001176