PCIDB

Polygonatum multiflorum

Species

KNApSAcK Entry

Organism name Polygonatum multiflorum
Genus Polygonatum
Family Convallariaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Polygonatum multiflorum
Linked NCBI taxonomy ID 45371
Linked level species

Family

Family in NCBI taxonomy Asparagaceae
ID 40552

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Liliopsida
ID 4447

Natural Activity

List (7)

Species Activity
Polygonatum multiflorum (L.) All. Antidiabetic
Polygonatum multiflorum (L.) All. Antiinflammatory
Polygonatum multiflorum (L.) All. Astringent
Polygonatum multiflorum (L.) All. Demulcent
Polygonatum multiflorum (L.) All. Diuretic
Polygonatum multiflorum (L.) All. Hypoglycemic
Polygonatum multiflorum (L.) All. Tonic

Metabolite list (5)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00006183 External link 512 Isocorymboside
CHEMBL1537012
7 / 2 / 2 No. 1 No. 15
C00040212 External link 512 Saponoside A
No. 4 No. 51
C00006097 External link 512 8-C-beta-D-Galactopyranosylapigenin
CHEMBL487417
CHEMBL1332209
CHEMBL1357921
16 / 4 / 8 No. 22 No. 15
C00001343 External link 512 L-Azetidine 2-carboxylic acid
CHEMBL33592
CHEMBL1165239
CHEMBL1599178
C089382
8 / 14 / 15 No. 1523 No. 1
C00001353 External link 512 L-alpha,gamma-Diaminobutyric acid
CHEMBL307931
CHEMBL102493
CHEMBL321357
5 / 2 / 3 No. 1538

Human Protein / Gene in interactions

22 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001343 C00001353 C00006097 1 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001343 C00001353 C00006097 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001343 C00001353 C00006097 1 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001343 C00001353 C00006097 0 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001343 C00001353 C00006097 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00006097 C00006183 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00006097 C00006183 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00006097 C00006183 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00006097 C00006183 1 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00006097 0 / 0
O75496 Geminin Unclassified protein C00006097 0 / 0
P15121 Aldose reductase Enzyme C00006097 0 / 0
P39748 Flap endonuclease 1 Enzyme C00006183 0 / 0
P54132 Bloom syndrome protein Enzyme C00001343 1 / 2
P02545 Prelamin-A/C Unclassified protein C00001343 11 / 10
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00006097 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00006183 1 / 1
Q7Z2H8 Proton-coupled amino acid transporter 1 Unclassified protein C00001343 0 / 0
P06746 DNA polymerase beta Enzyme C00006183 0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00006097 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00006097 1 / 4
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00006097 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (17)

OMIM preferred title UniProt
#210900 Bloom syndrome; blm P54132
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#232300 Glycogen storage disease ii P10253
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#275210 Restrictive dermopathy, lethal P02545
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (21)

KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)