Aconitum karakolicum
Species
KNApSAcK Entry
| Organism name | Aconitum karakolicum |
|---|---|
| Genus | Aconitum |
| Family | Ranunculaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Aconitum karakolicum |
|---|---|
| Linked NCBI taxonomy ID | 286046 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Ranunculaceae |
|---|---|
| ID | 3440 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | eudicotyledons |
|---|---|
| ID | 71240 |
Metabolite list (10)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00001649
|
Karakoline
|
CHEMBL1242438
CHEMBL1496845 CHEMBL1513445 CHEMBL1514236 CHEMBL1525359 CHEMBL1872961 |
8 / 14 / 15 | No. 31 | No. 10 |
|
||
|
C00001663
|
Songorin
/ Napellonin / Napellonine / Bullatine G |
CHEMBL1895895
CHEMBL2165580 |
C057217
|
1 / 0 / 0 | No. 124 | No. 10 |
|
|
|
C00001656
|
Napelline
/ Luciculine |
CHEMBL1487558
CHEMBL1741394 |
C109326
|
9 / 3 / 5 | No. 124 | No. 10 |
|
|
|
C00024959
|
Songoramine
/ Zongoramine |
No. 124 | No. 10 |
|
||||
|
C00024804
|
12-Acetylnapelline
/ 12-O-Acetylnapelline |
CHEMBL252513
|
No. 124 | No. 10 |
|
|||
|
C00024934
|
Songorin
/ Zongorine / Napellonine |
CHEMBL1895895
CHEMBL2165580 |
C057217
|
1 / 0 / 0 | No. 124 | No. 10 |
|
|
|
C00024869
|
Dehydrosongorine
|
No. 124 | No. 10 |
|
||||
|
C00024807
|
12-Epinapelline
/ 12-Epiluciculine / 12-epi-Napelline |
CHEMBL1487558
CHEMBL1741394 |
9 / 3 / 5 | No. 124 | No. 10 |
|
||
|
C00001610
|
Aconifine
|
CHEMBL2062833
|
No. 138 | No. 10 |
|
|||
|
C00024917
|
Karakomine
|
No. 1912 | No. 10 |
|
Human Protein / Gene in interactions
13 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001649 C00001656 C00024807 | 1 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001649 C00001656 C00024807 | 0 / 1 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001649 C00001656 C00024807 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001649 C00001656 C00024807 | 1 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001649 C00001656 C00024807 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00001656 C00024807 | 0 / 0 |
| P11308 | Transcriptional regulator ERG | Unclassified protein | C00001656 C00024807 | 1 / 2 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00001656 C00024807 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00001656 C00024807 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00001663 C00024934 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00001649 | 11 / 10 |
| P54132 | Bloom syndrome protein | Enzyme | C00001649 | 1 / 2 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00001649 | 0 / 0 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (15)
| OMIM | preferred title | UniProt |
|---|---|---|
| #210900 | Bloom syndrome; blm |
P54132
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #612219 | Ewing sarcoma; es |
P11308
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
KEGG DISEASE (17)
| KEGG | name | UniProt |
|---|---|---|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00024 | Prostate cancer |
P11308
(related)
|
| H00035 | Ewing's sarcoma |
P11308
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
|