Species

KNApSAcK Entry

Organism name Aconitum leucostomum Worosch.
Genus Aconitum
Family Ranunculaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Aconitum
Linked NCBI taxonomy ID 49188
Linked level genus

Family

Family in NCBI taxonomy Ranunculaceae
ID 3440

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (13)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00028471 External link 512 Leucostine A
No. 31 No. 10
C00001632 External link 512 Delcosine
CHEMBL2141282
2 / 7 / 3 No. 31 No. 10
C00001634 External link 512 Delsoline
CHEMBL1242534
CHEMBL1474356
CHEMBL2112855
C045308
8 / 15 / 13 No. 31 No. 10
C00028136 External link 512 Dehydroacosanine
/ (+)-Dehydroacosanine
No. 31 No. 10
C00028472 External link 512 Leucostine B
No. 31 No. 10
C00001663 External link 512 Songorin
/ Napellonin
/ Napellonine
/ Bullatine G
CHEMBL1895895
CHEMBL2165580
C057217
1 / 0 / 0 No. 124 No. 10
C00028458 External link 512 Lepenine
C054803
No. 124 No. 10
C00001615 External link 512 Anthranoyllycoctonine
CHEMBL359227
CHEMBL451362
CHEMBL1499239
CHEMBL1968141
11 / 33 / 28 No. 166 No. 10
C00028998 External link 512 Sepaconitine
No. 475 No. 10
C00028652 External link 512 N-Deacetyllappaconitine
CHEMBL453139
CHEMBL509076
CHEMBL2112851
C055260
No. 475 No. 10
C00001650 External link 512 Lappaconitine
CHEMBL1592229
CHEMBL1877754
CHEMBL1906763
CHEMBL2112849
C022150
3 / 5 / 4 No. 475 No. 10
C00028469 External link 512 Leuconine
No. 4061
C00028470 External link 512 Leucostine
No. 4061

Human Protein / Gene in interactions

20 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P02545 Prelamin-A/C Unclassified protein C00001615 C00001634 11 / 10
Q9UBT6 DNA polymerase kappa Enzyme C00001650 C00001663 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00001615 C00001632 7 / 3
O75496 Geminin Unclassified protein C00001632 C00001634 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00001615 C00001634 2 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001615 1 / 2
P17405 Sphingomyelin phosphodiesterase Enzyme C00001615 2 / 2
P07237 Protein disulfide-isomerase Enzyme C00001615 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001634 0 / 1
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001634 1 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00001615 0 / 0
P06280 Alpha-galactosidase A Enzyme C00001650 1 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001634 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00001615 2 / 2
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001634 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001634 0 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00001650 4 / 3
P04062 Glucosylceramidase Enzyme C00001615 6 / 4
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001615 0 / 0
O00255 Menin Unclassified protein C00001615 2 / 5

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (40)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P84022
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#166350 Osseous heteroplasia, progressive; poh P63092
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#275210 Restrictive dermopathy, lethal P02545
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (35)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00125 Fabry disease P06280 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)