Fumaria bastardii
Species
KNApSAcK Entry
| Organism name | Fumaria bastardii |
|---|---|
| Genus | Fumaria |
| Family | Fumariaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Fumaria bastardii |
|---|---|
| Linked NCBI taxonomy ID | 1155334 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Papaveraceae |
|---|---|
| ID | 3465 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | eudicotyledons |
|---|---|
| ID | 71240 |
Metabolite list (11)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00026150
|
Tetrahydropalmatine
/ dl-Tetrahydropalmatine / (+/-)-Tetrahydropalmatine |
CHEMBL187892
CHEMBL487182 CHEMBL2334889 |
8 / 5 / 2 | No. 37 | No. 4 |
|
||
|
C00026095
|
Stylopine
/ (-)-Stylopine / l-Tetrahydrocoptisine / (-)-Tetrahydrocoptisine |
CHEMBL1922602
|
No. 37 | No. 4 |
|
|||
|
C00025924
|
Juziphine
/ Yuziphine / (+)-Juziphine |
CHEMBL462956
|
No. 253 | No. 4 |
|
|||
|
C00027452
|
O-Acetylfumaricine
/ Fumaricine acetate / O-Methylfumarophycine / (-)-O-Methylfumarophycine |
No. 512 | No. 4 |
|
||||
|
C00027368
|
Fumariline
|
C049095
|
No. 512 | No. 4 |
|
|||
|
C00001820
|
Bucuculline
/ Bicucullin / (+)-Bicuculline |
CHEMBL417990
CHEMBL1316579 CHEMBL1437488 CHEMBL1444722 |
D001640
|
30 / 28 / 20 | 0 / 21 | No. 605 | No. 4 |
|
|
C00027303
|
beta-Hydrastine
|
CHEMBL475536
CHEMBL462731 CHEMBL1256868 CHEMBL1256919 CHEMBL1408680 CHEMBL1412842 CHEMBL1441048 |
C013024
|
21 / 35 / 30 | No. 605 | No. 4 |
|
|
|
C00027329
|
Corlumine
/ NSC 32983 / (+)-Carlumine / (+)-Corlumine |
CHEMBL510121
|
No. 605 | No. 4 |
|
|||
|
C00001906
|
Fumarin
/ Biflorine / Protopine / Fumarine / Corydinine |
CHEMBL453019
|
C009093
|
5 / 5 / 4 | 2 / 0 | No. 820 | No. 4 |
|
|
C00027136
|
Corydaldine
/ 3,4-Dihydro-6,7-dimethoxy-1(2H)-isoquinolone |
No. 2199 |
|
|||||
|
C00027458
|
Oxyhydrastinine
/ N-Methylnoroxyhydrastinine |
C048352
|
No. 3603 |
|
Human Protein / Gene in interactions
49 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001820 C00001906 C00026150 C00027303 | 0 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001820 C00001906 C00027303 | 1 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00001820 C00001906 C00027303 | 3 / 2 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001820 C00001906 C00027303 | 1 / 1 |
| P02545 | Prelamin-A/C | Unclassified protein | C00001820 C00027303 | 11 / 10 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00001820 C00027303 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00001906 C00027303 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001820 C00027303 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001820 C00027303 | 0 / 1 |
| O75496 | Geminin | Unclassified protein | C00001820 C00027303 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00027303 | 0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00001820 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00027303 | 0 / 0 |
| P54132 | Bloom syndrome protein | Enzyme | C00027303 | 1 / 2 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00026150 | 1 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00001820 | 0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00027303 | 0 / 1 |
| P13726 | Tissue factor | Membrane receptor | C00026150 | 0 / 0 |
| P14867 | Gamma-aminobutyric acid receptor subunit alpha-1 | GABA-A alpha | C00001820 | 1 / 1 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00027303 | 3 / 3 |
| Q01453 | Peripheral myelin protein 22 | Unclassified protein | C00027303 | 5 / 2 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00027303 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00026150 | 1 / 1 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00026150 | 0 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00026150 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00027303 | 1 / 1 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00026150 | 2 / 0 |
| P08908 | 5-hydroxytryptamine receptor 1A | Serotonin receptor | C00026150 | 1 / 0 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00027303 | 2 / 2 |
| P40225 | Thrombopoietin | Unclassified protein | C00027303 | 1 / 1 |
| P04062 | Glucosylceramidase | Enzyme | C00027303 | 6 / 4 |
| Q9UN88 | Gamma-aminobutyric acid receptor subunit theta | GABA-A theta | C00001820 | 0 / 0 |
| P28472 | Gamma-aminobutyric acid receptor subunit beta-3 | GABA-A beta | C00001820 | 1 / 0 |
| P48169 | Gamma-aminobutyric acid receptor subunit alpha-4 | GABA-A alpha | C00001820 | 0 / 0 |
| O14764 | Gamma-aminobutyric acid receptor subunit delta | GABA-A delta | C00001820 | 1 / 1 |
| P31644 | Gamma-aminobutyric acid receptor subunit alpha-5 | GABA-A alpha | C00001820 | 0 / 0 |
| Q99928 | Gamma-aminobutyric acid receptor subunit gamma-3 | GABA-A gamma | C00001820 | 0 / 0 |
| P78334 | Gamma-aminobutyric acid receptor subunit epsilon | GABA-A epsilon | C00001820 | 0 / 0 |
| Q8N1C3 | Gamma-aminobutyric acid receptor subunit gamma-1 | GABA-A gamma | C00001820 | 0 / 0 |
| P34903 | Gamma-aminobutyric acid receptor subunit alpha-3 | GABA-A alpha | C00001820 | 0 / 0 |
| O00591 | Gamma-aminobutyric acid receptor subunit pi | GABA-A pi | C00001820 | 0 / 0 |
| P47870 | Gamma-aminobutyric acid receptor subunit beta-2 | GABA-A beta | C00001820 | 0 / 0 |
| P18507 | Gamma-aminobutyric acid receptor subunit gamma-2 | GABA-A gamma | C00001820 | 4 / 2 |
| P18505 | Gamma-aminobutyric acid receptor subunit beta-1 | GABA-A beta | C00001820 | 0 / 0 |
| Q16445 | Gamma-aminobutyric acid receptor subunit alpha-6 | GABA-A alpha | C00001820 | 0 / 0 |
| P47869 | Gamma-aminobutyric acid receptor subunit alpha-2 | GABA-A alpha | C00001820 | 1 / 0 |
| Q9NY46 | Sodium channel protein type 3 subunit alpha | SCN alpha, NaV1.x | C00001820 | 0 / 0 |
| Q99250 | Sodium channel protein type 2 subunit alpha | SCN alpha, NaV1.x | C00001820 | 2 / 2 |
| P35498 | Sodium channel protein type 1 subunit alpha | SCN alpha, NaV1.x | C00001820 | 3 / 2 |
2 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00001906
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00001906
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (51)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #103780 | Alcohol dependence |
P14416
P47869 |
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #210900 | Bloom syndrome; blm |
P54132
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #118300 | Charcot-marie-tooth disease and deafness |
Q01453
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #118220 | Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a |
Q01453
|
| #607208 | Dravet syndrome |
P18507
P35498 |
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #607681 | Epilepsy, childhood absence, susceptibility to, 2; eca2 |
P18507
|
| #612269 | Epilepsy, childhood absence, susceptibility to, 5; eca5 |
P28472
|
| #613060 | Epilepsy, idiopathic generalized, susceptibility to, 10; eig10 |
O14764
|
| #611136 | Epilepsy, juvenile myoclonic, susceptibility to, 5; ejm5 |
P14867
|
| #613721 | Epileptic encephalopathy, early infantile, 11; eiee11 |
Q99250
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #604233 | Generalized epilepsy with febrile seizures plus, type 1; gefsp1 |
P18507
|
| #604403 | Generalized epilepsy with febrile seizures plus, type 2; gefsp2 |
P35498
|
| #611277 | Generalized epilepsy with febrile seizures plus, type 3; gefsp3 |
P18507
|
| #139393 | Guillain-barre syndrome, familial; gbs |
Q01453
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #145900 | Hypertrophic neuropathy of dejerine-sottas |
Q01453
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #609634 | Migraine, familial hemiplegic, 3; fhm3 |
P35498
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #159900 | Myoclonic dystonia |
P14416
|
| #162500 | Neuropathy, hereditary, with liability to pressure palsies; hnpp |
Q01453
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #614674 | Periodic fever, menstrual cycle-dependent |
P08908
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #607745 | Seizures, benign familial infantile, 3; bfis3 |
Q99250
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #187950 | Thrombocythemia 1; thcyt1 |
P40225
|
KEGG DISEASE (36)
| KEGG | name | UniProt |
|---|---|---|
| H00783 | Febrile seizures |
O14764
(related)
P18507 (related) P35498 (related) |
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
Q01453 (related) |
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
|
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00808 | Idiopathic generalized epilepsies (IGEs) |
P14867
(related)
P18507 (related) |
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00775 | Familial or sporadic hemiplegic migraine |
P35498
(related)
|
| H00227 | Congenital amegakaryocytic thrombocytopenia (CAMT) |
P40225
(marker)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
|
| H01296 | Hereditary neuropathy with liability to pressure palsies (HNPP) |
Q01453
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00606 | Early infantile epileptic encephalopathy |
Q99250
(related)
|
| H00806 | Benign familial neonatal and infantile epilepsies |
Q99250
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
Diseases related to CTD interactions
21 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D000647 | Amnesia |
C00001820
|
| D000648 | Amnesia, Retrograde |
C00001820
|
| D001008 | Anxiety Disorders |
C00001820
|
| D001919 | Bradycardia |
C00001820
|
| D002375 | Catalepsy |
C00001820
|
| D004487 | Edema |
C00001820
|
| D004827 | Epilepsy |
C00001820
|
| D005119 | Extravasation of Diagnostic and Therapeutic Materials |
C00001820
|
| D006930 | Hyperalgesia |
C00001820
|
| D006973 | Hypertension |
C00001820
|
| D007022 | Hypotension |
C00001820
|
| D009069 | Movement Disorders |
C00001820
|
| D009207 | Myoclonus |
C00001820
|
| D009436 | Neural Tube Defects |
C00001820
|
| D020078 | Neurogenic Inflammation |
C00001820
|
| D020336 | Paraparesis, Spastic |
C00001820
|
| D010409 | Penile Diseases |
C00001820
|
| D049188 | Prenatal Injuries |
C00001820
|
| D012640 | Seizures |
C00001820
|
| D013035 | Spasm |
C00001820
|
| D013226 | Status Epilepticus |
C00001820
|