Litsea cubeba
Species
KNApSAcK Entry
| Organism name | Litsea cubeba |
|---|---|
| Genus | Litsea |
| Family | Lauraceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Litsea cubeba |
|---|---|
| Linked NCBI taxonomy ID | 155299 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Lauraceae |
|---|---|
| ID | 3433 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | Magnoliophyta |
|---|---|
| ID | 3398 |
Metabolite list (19)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00027225
|
N-Methyllindcarpine
/ (+)-N-Methyllindcarpine |
No. 20 | No. 4 |
|
||||
|
C00001869
|
Isoboldine
/ (S)-Isoboldine |
CHEMBL462880
|
19 / 22 / 55 | No. 20 | No. 4 |
|
||
|
C00027304
|
Boldine
/ d-Boldine / (+)-Boldine |
CHEMBL388342
CHEMBL1321247 CHEMBL1437753 |
C011686
|
34 / 32 / 35 | No. 20 | No. 4 |
|
|
|
C00027551
|
Isodomesticine
/ (+)-1-Methoxy-2-hydroxy-9,10-methylenedioxyaporphine |
No. 20 | No. 4 |
|
||||
|
C00027438
|
Sanjoinine Ib
/ Norisocorydine |
CHEMBL465212
|
No. 20 | No. 4 |
|
|||
|
C00027409
|
Laurotetanin
/ Laurotetanine / (+)-Laurotetanine |
CHEMBL464098
|
C008256
|
No. 20 | No. 4 |
|
||
|
C00025931
|
Liriotulipiferine
|
CHEMBL1996399
|
No. 20 | No. 4 |
|
|||
|
C00027433
|
Laurolitsine
/ (+)-Norboldine / (+)-Laurolitsine |
CHEMBL487388
|
C109133
|
No. 20 | No. 4 |
|
||
|
C00025675
|
Lauroscholtzine
/ 2-O-Methylboldine / N-Methyllaurotetanine / (+)-N-Methyllaurotetanine |
CHEMBL464099
|
1 / 1 / 0 | No. 20 | No. 4 |
|
||
|
C00027170
|
Xanthoplanine
/ (+)-Xanthoplanine |
CHEMBL1180065
|
No. 286 | No. 4 |
|
|||
|
C00001910
|
Reticuline
/ (+)-Reticuline |
CHEMBL235212
CHEMBL401501 CHEMBL464734 |
C003298
|
1 / 0 / 0 | No. 345 | No. 4 |
|
|
|
C00001862
|
Glaziovine
/ L-Glaziovine / N-Methylcrotsparine / L-(-)-N-Methylcrotsparine |
CHEMBL1980854
|
C007847
|
No. 688 |
|
|||
|
C00025937
|
Magnocurarine
/ (-)-Magnocurarine / (R)-Magnocurarine |
CHEMBL1187634
CHEMBL1963333 |
C048506
|
No. 896 |
|
|||
|
C00027601
|
(-)-8-O-Methyloblongine
|
No. 896 |
|
|||||
|
C00003035
|
Geranial
/ (E)-alpha-Citral |
CHEMBL1080997
|
6 / 7 / 9 | No. 1575 | No. 34 |
|
||
|
C00003036
|
Neral
/ Citral Z |
CHEMBL1080997
|
6 / 7 / 9 | No. 1575 | No. 34 |
|
||
|
C00035822
|
Citral (E/Z)
|
CHEMBL1080997
|
C007076
|
6 / 7 / 9 | 7 / 1 | No. 1575 | No. 34 |
|
|
C00027609
|
(-)-Oblongine
|
CHEMBL392270
CHEMBL459418 |
2 / 2 / 0 | No. 2248 |
|
|||
|
C00028482
|
Litebamine
|
CHEMBL453173
|
C109134
|
No. 4053 |
|
Human Protein / Gene in interactions
45 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00001869 C00003035 C00003036 C00027304 C00035822 | 1 / 4 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00001869 C00003035 C00003036 C00027304 C00035822 | 0 / 1 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001869 C00003035 C00003036 C00027304 C00035822 | 0 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00003035 C00003036 C00035822 | 3 / 1 |
| O00519 | Fatty-acid amide hydrolase 1 | Enzyme | C00003035 C00003036 C00035822 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00003035 C00003036 C00035822 | 3 / 4 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00001869 C00027304 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00001869 C00027304 | 4 / 3 |
| O00255 | Menin | Unclassified protein | C00001869 C00027304 | 2 / 5 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001869 C00027304 | 0 / 1 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00001869 C00027304 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001869 C00027304 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001869 C00027304 | 1 / 1 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001869 C00027304 | 1 / 2 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00001869 C00027304 | 2 / 2 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00001869 C00027304 | 3 / 3 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00001869 C00027304 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001869 C00027304 | 1 / 0 |
| O75496 | Geminin | Unclassified protein | C00027304 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00027304 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00027304 | 1 / 1 |
| P36544 | Neuronal acetylcholine receptor subunit alpha-7 | CHRN alpha | C00027304 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00027304 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00027304 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00027304 | 0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00027304 | 0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00027304 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00001910 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00027609 | 0 / 0 |
| P55210 | Caspase-7 | C14 | C00001869 | 0 / 0 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00027304 | 1 / 0 |
| P43681 | Neuronal acetylcholine receptor subunit alpha-4 | CHRN alpha | C00027304 | 1 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00027304 | 0 / 0 |
| P17787 | Neuronal acetylcholine receptor subunit beta-2 | CHRN beta | C00027304 | 1 / 1 |
| P02545 | Prelamin-A/C | Unclassified protein | C00027304 | 11 / 10 |
| P08908 | 5-hydroxytryptamine receptor 1A | Serotonin receptor | C00025675 | 1 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00027304 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00001869 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00027304 | 1 / 1 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00001869 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00027304 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00027304 | 1 / 1 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00027304 | 0 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00001869 | 7 / 37 |
| P18054 | Arachidonate 12-lipoxygenase, 12S-type | Enzyme | C00027609 | 2 / 0 |
7 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1646 | AKR1C2, AKR1C-pseudo, BABP, DD, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8 | aldo-keto reductase family 1, member C2 (EC:1.3.1.20 1.1.1.357) |
C00035822
|
| 1555 | CYP2B6, CPB6, CYP2B, CYP2B7, CYP2B7P, CYPIIB6, EFVM, IIB1, P450 | cytochrome P450, family 2, subfamily B, polypeptide 6 (EC:1.14.14.1) |
C00035822
|
| 2099 | ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 | estrogen receptor 1 |
C00035822
|
| 2100 | ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 | estrogen receptor 2 (ER beta) |
C00035822
|
| 3162 | HMOX1, HMOX1D, HO-1, HSP32, bK286B10 | heme oxygenase (decycling) 1 (EC:1.14.99.3) |
C00035822
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00035822
|
| 23764 | MAFF, U-MAF, hMafF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F |
C00035822
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (47)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P18054
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #600513 | Epilepsy, nocturnal frontal lobe, 1; enfl1 |
P43681
|
| #605375 | Epilepsy, nocturnal frontal lobe, 3; enfl3 |
P17787
|
| #133239 | Esophageal cancer |
P04637
P18054 |
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #211980 | Lung cancer |
P04637
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #614674 | Periodic fever, menstrual cycle-dependent |
P08908
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (74)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
Q01196 (related) |
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00807 | Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) |
P17787
(related)
P43681 (related) |
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|