Eucalyptus spp.
Species
KNApSAcK Entry
| Organism name | Eucalyptus spp. |
|---|---|
| Genus | Eucalyptus |
| Family | Myrtaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Eucalyptus |
|---|---|
| Linked NCBI taxonomy ID | 3932 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Myrtaceae |
|---|---|
| ID | 3931 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (24)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00006709
|
Delphin
/ Delphinidin 3,5-diglucoside |
No. 1 | No. 15 |
|
||||
|
C00004635
|
Isorhamnetin
/ 3'-O-Methylquercetin / 3,4',5,7-Tetrahydroxy-3'-methoxyflavone / 3,5,7-Trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-1-benzopyran-4-one |
CHEMBL379064
|
C047368
|
12 / 10 / 13 | 10 / 0 | No. 3 | No. 15 |
|
|
C00008143
|
Alpinetin
/ (-)-Alpinetin |
CHEMBL427218
CHEMBL254825 |
No. 25 | No. 14 |
|
|||
|
C00000992
|
Pinocembrin
|
CHEMBL70518
CHEMBL399910 CHEMBL399249 |
C016063
|
18 / 23 / 23 | 5 / 0 | No. 25 | No. 14 |
|
|
C00009095
|
Procyanidin C4
|
CHEMBL290632
|
13 / 5 / 6 | No. 29 | No. 19 |
|
||
|
C00002870
|
Astringin
/ (E)-Astringin / 3,4,3',5'-Tetrahydroxystilbene 3'-glucoside |
CHEMBL358769
CHEMBL469920 |
No. 36 | No. 13 |
|
|||
|
C00008554
|
Aromadendrin 3-methyl ether
|
No. 42 | No. 14 |
|
||||
|
C00007234
|
Katuranin
/ (+)-Aromadendrin / (+)-Dihydrokaempferol / (2R,3R)-2,3-Dihydro-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one |
CHEMBL9323
CHEMBL1933859 |
C080220
|
4 / 3 / 3 | No. 42 | No. 14 |
|
|
|
C00008556
|
Aromadendrin 7-methyl ether
|
CHEMBL491541
CHEMBL452130 |
No. 42 | No. 14 |
|
|||
|
C00001271
|
Tritriacontane-16,18-dione
|
C071369
|
0 / 2 | No. 115 |
|
|||
|
C00003110
|
Caryophyllene
/ (E)-Caryophyllene / beta-Caryophyllene / (-)-(E)-Caryophyllene / (E)-beta-Caryophyllene |
CHEMBL445740
CHEMBL448700 |
2 / 3 / 7 | No. 478 | No. 38 |
|
||
|
C00000163
|
alpha-Eudesmol
|
C118684
|
No. 524 | No. 38 |
|
|||
|
C00000164
|
beta-Eudesmol
|
CHEMBL88244
|
C051082
|
No. 524 | No. 38 |
|
||
|
C00010931
|
(R)-(+)-alpha-Terpineol
/ (R)-(+)-p-Menth-1-en-8-ol |
CHEMBL447597
CHEMBL449810 |
3 / 16 / 11 | No. 983 | No. 35 |
|
||
|
C00010932
|
(S)-(-)-alpha-Terpineol
/ (S)-(-)-p-Menth-1-en-8-ol |
CHEMBL447597
CHEMBL449810 |
3 / 16 / 11 | No. 983 | No. 35 |
|
||
|
C00010925
|
trans-(-)-Piperitol
/ (3S,4S)-(-)-p-Menth-1-en-3-ol |
No. 1052 | No. 35 |
|
||||
|
C00010911
|
(S)-(-)-Phellandral
|
No. 1052 | No. 35 |
|
||||
|
C00000184
|
alpha-Thujene
|
No. 1343 | No. 35 |
|
||||
|
C00003051
|
alpha-Phellandrene
|
CHEMBL455041
|
C005403
|
No. 1898 | No. 35 |
|
||
|
C00010872
|
beta-Phellandrene
/ (+/-)-beta-Phellandrene |
CHEMBL444254
|
C058582
|
No. 1898 | No. 35 |
|
||
|
C00003061
|
gamma-Terpinene
/ 1-Methyl-4-(1-methylethyl)-1,4-cyclohexadiene |
CHEMBL449693
|
C018669
|
No. 2468 | No. 35 |
|
||
|
C00003060
|
alpha-Terpinene
|
No. 2468 | No. 35 |
|
||||
|
C00010905
|
p-Isopropenyltoluene
/ alpha,4-Dimethylstyrene |
No. 4248 |
|
|||||
|
C00010860
|
(R)-(-)-Cryptone
|
No. 5639 |
|
Human Protein / Gene in interactions
43 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00000992 C00003110 C00004635 | 1 / 2 |
| O00255 | Menin | Unclassified protein | C00000992 C00003110 C00004635 | 2 / 5 |
| P02545 | Prelamin-A/C | Unclassified protein | C00010931 C00010932 | 11 / 10 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00010931 C00010932 | 5 / 1 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00000992 C00004635 | 0 / 0 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00010931 C00010932 | 3 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000992 C00004635 | 0 / 0 |
| Q16678 | Cytochrome P450 1B1 | Cytochrome P450 1B1 | C00000992 C00004635 | 4 / 4 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00000992 C00007234 | 0 / 0 |
| P04798 | Cytochrome P450 1A1 | Cytochrome P450 1A1 | C00000992 C00004635 | 0 / 0 |
| P08253 | 72 kDa type IV collagenase | M10A | C00009095 | 1 / 3 |
| P04792 | Heat shock protein beta-1 | Unclassified protein | C00004635 | 2 / 1 |
| P36888 | Receptor-type tyrosine-protein kinase FLT3 | Pdgfr | C00007234 | 1 / 1 |
| P39748 | Flap endonuclease 1 | Enzyme | C00004635 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00007234 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00000992 | 7 / 3 |
| P11309 | Serine/threonine-protein kinase pim-1 | Pim | C00000992 | 0 / 0 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00007234 | 2 / 2 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00004635 | 1 / 1 |
| P04745 | Alpha-amylase 1 | Enzyme | C00004635 | 0 / 0 |
| P08047 | Transcription factor Sp1 | Unclassified protein | C00000992 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000992 | 0 / 1 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00000992 | 3 / 3 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00000992 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000992 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000992 | 0 / 1 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00000992 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00009095 | 2 / 2 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00000992 | 4 / 3 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00004635 | 0 / 0 |
| P09917 | Arachidonate 5-lipoxygenase | Oxidoreductase | C00004635 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000992 | 1 / 0 |
| Q05513 | Protein kinase C zeta type | Iota | C00009095 | 0 / 0 |
| Q04759 | Protein kinase C theta type | Delta | C00009095 | 0 / 1 |
| Q02156 | Protein kinase C epsilon type | Eta | C00009095 | 0 / 0 |
| O94806 | Serine/threonine-protein kinase D3 | Pkd | C00009095 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00009095 | 0 / 0 |
| Q05655 | Protein kinase C delta type | Delta | C00009095 | 0 / 0 |
| P05129 | Protein kinase C gamma type | Alpha | C00009095 | 1 / 1 |
| P05771 | Protein kinase C beta type | Alpha | C00009095 | 0 / 0 |
| P24723 | Protein kinase C eta type | Eta | C00009095 | 1 / 0 |
| P41743 | Protein kinase C iota type | Iota | C00009095 | 0 / 0 |
| Q15139 | Serine/threonine-protein kinase D1 | Pkd | C00009095 | 0 / 0 |
15 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00000992
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00000992
|
| 6817 | SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) |
C00000992
|
| 6818 | SULT1A3, HAST, HAST3, M-PST, ST1A3/ST1A4, ST1A5, STM, TL-PST | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC:2.8.2.1) |
C00000992
|
| 7052 | TGM2, G-ALPHA-h, GNAH, TG2, TGC | transglutaminase 2 (EC:2.3.2.13) |
C00000992
|
| 5243 | ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) |
C00004635
|
| 4363 | ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 |
C00004635
|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00004635
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00004635
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00004635
|
| 2099 | ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 | estrogen receptor 1 |
C00004635
|
| 2100 | ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 | estrogen receptor 2 (ER beta) |
C00004635
|
| 4846 | NOS3, ECNOS, eNOS | nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) |
C00004635
|
| 4973 | OLR1, CLEC8A, LOX1, LOXIN, SCARE1, SLOX1 | oxidized low density lipoprotein (lectin-like) receptor 1 |
C00004635
|
| 7031 | TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2 | trefoil factor 1 |
C00004635
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (50)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #606595 | Charcot-marie-tooth disease, axonal, type 2f; cmt2f |
P04792
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
| #606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #143500 | Gilbert syndrome |
P22309
P22310 |
| #137750 | Glaucoma 1, open angle, a; glc1a |
Q16678
|
| #231300 | Glaucoma 3, primary congenital, a; glc3a |
Q16678
|
| #137760 | Glaucoma, primary open angle; poag |
Q16678
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #601626 | Leukemia, acute myeloid; aml |
P36888
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #259600 | Multicentric osteolysis, nodulosis, and arthropathy; mona |
P08253
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #608634 | Neuronopathy, distal hereditary motor, type iib; hmn2b |
P04792
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #604229 | Peters anomaly |
Q16678
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #605361 | Spinocerebellar ataxia 14; sca14 |
P05129
|
| #601367 | Stroke, ischemic |
P24723
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #278300 | Xanthinuria, type i |
P47989
|
KEGG DISEASE (45)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00856 | Distal hereditary motor neuropathies (dHMN) |
P04792
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
P05129
(related)
|
| H00025 | Penile cancer |
P08253
(related)
P14780 (related) |
| H00028 | Choriocarcinoma |
P08253
(related)
|
| H00472 | Torg-Winchester syndrome |
P08253
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P11511
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00003 | Acute myeloid leukemia (AML) |
P36888
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00408 | Type I diabetes mellitus |
Q04759
(related)
|
| H00612 | Primary open angle glaucoma |
Q16678
(related)
|
| H01075 | Peters anomaly |
Q16678
(related)
|
| H01159 | Anterior segment dysgenesis (ASD) |
Q16678
(related)
|
| H01203 | Primary congenital glaucoma (PCG) |
Q16678
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|