Species

KNApSAcK Entry

Organism name Citrus unshiu
Genus Citrus
Family Rutaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Citrus unshiu
Linked NCBI taxonomy ID 55188
Linked level species

Family

Family in NCBI taxonomy Rutaceae
ID 23513

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (23)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00006232 External link 512 3,6-Di-C-glucosylapigenin
No. 1 No. 15
C00005715 External link 512 Limocitrin 3-glucoside
/ Limocitrin 3-O-beta-glucopyranoside
/ Limocitrin 3-O-beta-D-glucopyranoside
No. 2 No. 15
C00005716 External link 512 Limocitrin 3-rhamnoside
No. 2 No. 15
C00000009 External link 512 GA9
/ Gibberellin A9
No. 40 No. 41
C00000008 External link 512 GA8
/ Gibberellin A8
No. 40 No. 41
C00000004 External link 512 GA4
/ Gibberellin A4
No. 40 No. 41
C00000020 External link 512 GA20
/ Gibberellin A20
No. 40 No. 41
C00000029 External link 512 GA29
/ Gibberellin A29
No. 40 No. 41
C00000044 External link 512 GA44
/ Gibberellin A44
No. 40 No. 41
C00000001 External link 512 GA1
/ Gibberellin A1
C422660
No. 40 No. 41
C00000987 External link 512 Neohesperidin
CHEMBL506398
CHEMBL1885559
1 / 0 / 0 No. 48 No. 14
C00000017 External link 512 GA17
/ Gibberellin A17
No. 187 No. 41
C00000024 External link 512 GA24
/ Gibberellin A24
C120176
No. 187 No. 41
C00000019 External link 512 GA19
/ Gibberellin A19
C120175
No. 187 No. 41
C00000025 External link 512 GA25
/ Gibberellin A25
No. 187 No. 41
C00000053 External link 512 GA53
/ Gibberellin A53
No. 187 No. 41
C00000805 External link 512 alpha-Pinene
CHEMBL442565
C005451
3 / 3 / 2 0 / 1 No. 476 No. 35
C00000108 External link 512 IAM
/ Indole-3-acetamide
/ 1H-Indole-3-acetamide
C015950
No. 710 No. 4
C00000803 External link 512 (-)-Limonene
CHEMBL15799
CHEMBL449062
7 / 21 / 48 No. 848 No. 35
C00000100 External link 512 IAA
/ Indole-3-acetic acid
CHEMBL82411
C030737
3 / 0 / 0 2 / 1 No. 1432 No. 4
C00000848 External link 512 Isopentenyl diphosphate
CHEMBL356362
C004809
7 / 2 No. 3297
C00000846 External link 512 Geranyl diphosphate
/ Geranyl pyrophosphate
CHEMBL41342
C015234
1 / 0 / 0 2 / 0 No. 3475 No. 34
C00000101 External link 512 IAA methyl ester
/ Methyl indole-3-acetate
No. 4225

Human Protein / Gene in interactions

15 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P04637 Cellular tumor antigen p53 Transcription Factor C00000803 7 / 37
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000803 0 / 3
Q16773 Kynurenine--oxoglutarate transaminase 1 Enzyme C00000100 0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00000803 0 / 0
P02545 Prelamin-A/C Unclassified protein C00000803 11 / 10
P16473 Thyrotropin receptor Glycohormone receptor C00000805 3 / 2
P10828 Thyroid hormone receptor beta NR1A2 C00000803 3 / 1
P19793 Retinoic acid receptor RXR-alpha NR2B1 C00000803 0 / 0
P02768 Serum albumin Secreted protein C00000100 0 / 0
P14324 Farnesyl pyrophosphate synthase Transferase C00000846 0 / 0
Q9HBH1 Peptide deformylase, mitochondrial Enzyme C00000100 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00000805 0 / 0
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00000805 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00000803 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00000987 0 / 0

11 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1234 CCR5, CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22 chemokine (C-C motif) receptor 5 (gene/pseudogene) C00000848
2224 FDPS, FPPS, FPS farnesyl diphosphate synthase (EC:2.5.1.1 2.5.1.10) C00000848
2254 FGF9, FGF-9, GAF, HBFG-9, HBGF-9, SYNS3 fibroblast growth factor 9 C00000848
3458 IFNG, IFG, IFI interferon, gamma C00000848
3559 IL2RA, CD25, IDDM10, IL2R, TCGFR interleukin 2 receptor, alpha C00000848
162514 TRPV3, OLMS, VRL3 transient receptor potential cation channel, subfamily V, member 3 C00000848
7421 VDR, NR1I1 vitamin D (1,25- dihydroxyvitamin D3) receptor C00000848
3156 HMGCR, LDLCQ3 3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) C00000846
5906 RAP1A, KREV-1, KREV1, RAP1, SMGP21 RAP1A, member of RAS oncogene family C00000846
196 AHR, bHLHe76 aryl hydrocarbon receptor C00000100
405 ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 aryl hydrocarbon receptor nuclear translocator C00000100

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (24)

OMIM preferred title UniProt
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#211980 Lung cancer P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#260500 Papilloma of choroid plexus; cpp P04637
#275210 Restrictive dermopathy, lethal P02545
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828

KEGG DISEASE (50)

KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P35354 (related)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00033 Adrenal carcinoma P04637 (related)
H00036 Osteosarcoma P04637 (related)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
P35354 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)

Diseases related to CTD interactions

4 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D006930 Hyperalgesia C00000848
D010146 Pain C00000848
D003877 Dermatitis, Contact C00000805
D056486 Drug-Induced Liver Injury C00000100