PCIDB

Alnus glutinosa

Species

KNApSAcK Entry

Organism name Alnus glutinosa
Genus Alnus
Family Betulaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Alnus glutinosa
Linked NCBI taxonomy ID 3517
Linked level species

Family

Family in NCBI taxonomy Betulaceae
ID 3514

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Natural Activity

List (10)

Species Activity
Alnus glutinosa (L.) Gaertn. Alterative
Alnus glutinosa (L.) Gaertn. Astringent
Alnus glutinosa (L.) Gaertn. Dentifrice
Alnus glutinosa (L.) Gaertn. Detergent
Alnus glutinosa (L.) Gaertn. Diaphoretic
Alnus glutinosa (L.) Gaertn. Diuretic
Alnus glutinosa (L.) Gaertn. Hemostat
Alnus glutinosa (L.) Gaertn. Pulifuge
Alnus glutinosa (L.) Gaertn. Tonic
Alnus glutinosa (L.) Gaertn. Vermifuge

Metabolite list (12)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00004636 External link 512 Tamarixetin
/ 4'-O-Methylquercetin
/ 3,3',5,7-Tetrahydroxy-4'-methoxyflavone
/ 3,5,7-Trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one
CHEMBL226034
5 / 6 / 5 No. 3 No. 15
C00004690 External link 512 Laciniatin
/ 3,5,7-Trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-6-methoxy-4H-1-benzopyran-4-one
No. 3 No. 15
C00001051 External link 512 6-Hydroxykaempferol
CHEMBL455504
No. 3 No. 15
C00001096 External link 512 Santin
CHEMBL161957
C104803
9 / 7 / 5 No. 3 No. 15
C00004698 External link 512 Eupatin
CHEMBL77588
15 / 7 / 2 No. 3 No. 15
C00004596 External link 512 6-Methoxykaempferol 3-methyl ether
/ 5,7,4'-Trihydroxy-3,6-dimethoxyflavone
/ 5,7-Dihydroxy-2-(4-hydroxyphenyl)-3,6-dimethoxy-4H-1-benzopyran-4-one
CHEMBL351607
C014868
No. 3 No. 15
C00004694 External link 512 Centaureidin
/ Desmethoxycentaureidine
/ Quercetagetin 3,4',6-trimethyl ether
/ 5,7,3'-Trihydroxy-3,6,4'-trimethoxyflavone
/ 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,6-dimethoxy-4H-1-benzopyran-4-one
CHEMBL77552
C083161
24 / 14 / 6 No. 3 No. 15
C00023791 External link 512 Alnusenone
/ Friedoolean-5-en-3-one
CHEMBL517609
1 / 0 / 0 No. 13 No. 51
C00003758 External link 512 Alnulin
/ Tiliadin
/ Skimmiol
/ Taraxerol
CHEMBL511822
CHEMBL470462
C005802
No. 13 No. 51
C00032287 External link 512 Taraxerone
CHEMBL519077
CHEMBL1990874
C009379
No. 13 No. 51
C00000181 External link 512 Castasterone
C083545
No. 68 No. 11
C00000176 External link 512 Brassinolide
CHEMBL563853
CHEMBL1801925
CHEMBL1967970
C023623
16 / 2 No. 68 No. 11

Human Protein / Gene in interactions

35 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q9BVA1 Tubulin beta-2B chain Structural C00004694 C00004698 1 / 0
Q99700 Ataxin-2 Unclassified protein C00001096 C00004694 1 / 1
Q9BUF5 Tubulin beta-6 chain Structural C00004694 C00004698 0 / 0
Q9BQE3 Tubulin alpha-1C chain Unclassified protein C00004694 C00004698 0 / 0
Q6PEY2 Tubulin alpha-3E chain Unclassified protein C00004694 C00004698 0 / 0
Q13885 Tubulin beta-2A chain Structural C00004694 C00004698 0 / 0
P68363 Tubulin alpha-1B chain Unclassified protein C00004694 C00004698 0 / 0
Q13509 Tubulin beta-3 chain Structural C00004694 C00004698 2 / 1
P68371 Tubulin beta-4B chain Structural C00004694 C00004698 0 / 0
Q71U36 Tubulin alpha-1A chain Structural C00004694 C00004698 1 / 1
O75496 Geminin Unclassified protein C00001096 C00004694 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00001096 C00004694 0 / 0
P07437 Tubulin beta chain Structural C00004694 C00004698 0 / 0
Q3ZCM7 Tubulin beta-8 chain Structural C00004694 C00004698 0 / 0
P04350 Tubulin beta-4A chain Structural C00004694 C00004698 2 / 0
Q9H4B7 Tubulin beta-1 chain Structural C00004694 C00004698 1 / 0
P68366 Tubulin alpha-4A chain Structural C00004694 C00004698 0 / 0
Q13748 Tubulin alpha-3C/D chain Structural C00004694 C00004698 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00001096 C00004694 1 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00001096 4 / 3
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00004636 0 / 0
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 C00004636 4 / 4
P51843 Nuclear receptor subfamily 0 group B member 1 Nuclear hormone receptor subfamily 0 group B member 1 C00004694 2 / 2
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00001096 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00004694 1 / 1
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00004694 2 / 0
P39748 Flap endonuclease 1 Enzyme C00004694 0 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00023791 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00004694 0 / 0
P04792 Heat shock protein beta-1 Unclassified protein C00004636 2 / 1
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 C00004636 0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00001096 1 / 1
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00004636 0 / 0
P14618 Pyruvate kinase PKM Enzyme C00001096 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00001096 0 / 0

16 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00000176
598 BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS BCL2-like 1 C00000176
637 BID, FP497 BH3 interacting domain death agonist C00000176
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00000176
891 CCNB1, CCNB cyclin B1 C00000176
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00000176
898 CCNE1, CCNE cyclin E1 C00000176
1017 CDK2, p33(CDK2) cyclin-dependent kinase 2 (EC:2.7.11.22) C00000176
1019 CDK4, CMM3, PSK-J3 cyclin-dependent kinase 4 (EC:2.7.11.22) C00000176
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00000176
1027 CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 cyclin-dependent kinase inhibitor 1B (p27, Kip1) C00000176
2099 ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 estrogen receptor 1 C00000176
2100 ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 estrogen receptor 2 (ER beta) C00000176
4193 MDM2, ACTFS, HDMX, hdm2 MDM2 oncogene, E3 ubiquitin protein ligase C00000176
5925 RB1, OSRC, RB, p105-Rb, pRb, pp110 retinoblastoma 1 C00000176
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00000176

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (25)

OMIM preferred title UniProt
#300018 46,xy sex reversal 2; srxy2 P51843
#300200 Adrenal hypoplasia, congenital; ahc P51843
#606595 Charcot-marie-tooth disease, axonal, type 2f; cmt2f P04792
#114500 Colorectal cancer; crc P84022
#614039 Cortical dysplasia, complex, with other brain malformations 1; cdcbm1 Q13509
#128101 Dystonia 4, torsion, autosomal dominant; dyt4 P04350
#600638 Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement; cfeom3a Q13509
#600274 Frontotemporal dementia; ftd P10636
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#137800 Glioma susceptibility 1; glm1 O75874
#612438 Leukodystrophy, hypomyelinating, 6; hld6 P04350
#611603 Lissencephaly 3; lis3 Q71U36
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613112 Macrothrombocytopenia, autosomal dominant, tubb1-related Q9H4B7
#608634 Neuronopathy, distal hereditary motor, type iib; hmn2b P04792
#260540 Parkinson-dementia syndrome P10636
#604229 Peters anomaly Q16678
#172700 Pick disease of brain P10636
#610031 Polymicrogyria, symmetric or asymmetric; pmgysa Q9BVA1
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (15)

KEGG name UniProt
H00856 Distal hereditary motor neuropathies (dHMN) P04792 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00192 Xanthinuria P47989 (related)
H00552 Glycerol kinase deficiency (GKD) P51843 (related)
H00607 46,XY disorders of sex development (Disorders of gonadal development) P51843 (related)
H00838 Congenital fibrosis of the extraocular muscles (CFEOM) Q13509 (related)
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)
H00268 Lissencephaly (LIS) Q71U36 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

2 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D001943 Breast Neoplasms C00000176
D011471 Prostatic Neoplasms C00000176