PCIDB

KNApSAcK Metabolite C00000176

Metabolite

KNApSAcK Entry

id C00000176
Name Brassinolide
CAS RN 72962-43-7
Standard InChI InChI=1S/C28H48O6/c1-14(2)15(3)24(31)25(32)16(4)18-7-8-19-17-13-34-26(33)21-11-22(29)23(30)12-28(21,6)20(17)9-10-27(18,19)5/h14-25,29-32H,7-13H2,1-6H3/t15-,16-,17?,18?,19?,20?,21+,22-,23+,24+,25+,27+,28+/m0/s1
Standard InChI (Main Layer) InChI=1S/C28H48O6/c1-14(2)15(3)24(31)25(32)16(4)18-7-8-19-17-13-34-26(33)21-11-22(29)23(30)12-28(21,6)20(17)9-10-27(18,19)5/h14-25,29-32H,7-13H2,1-6H3

Cluster

Phytochemical cluster No. 11
KCF-S cluster No. 68

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL563853 CHEMBL1801925 CHEMBL1967970

KEGG

By LinkDB C08814

CTD

By CAS RN C023623

Human Protein / Gene in interaction

CTD interaction (19)

compound gene gene name gene description interaction interaction type form reference
pmid
C023623 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 brassinolide results in decreased expression of BCL2 protein decreases expression
protein 17557751
20833159
C023623 598 BCL2L1
BCL-XL/S
BCL2L
BCLX
BCLXL
BCLXS
Bcl-X
PPP1R52
bcl-xL
bcl-xS
BCL2-like 1 brassinolide results in decreased expression of BCL2L1 protein decreases expression
protein 20833159
C023623 637 BID
FP497
BH3 interacting domain death agonist brassinolide results in decreased expression of BID protein decreases expression
protein 20833159
C023623 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) brassinolide results in increased activity of CASP3 protein increases activity
protein 17557751
C023623 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) brassinolide results in increased expression of CASP3 protein modified form increases expression
protein 20833159
C023623 891 CCNB1
CCNB
cyclin B1 brassinolide results in decreased expression of CCNB1 protein decreases expression
protein 20833159
C023623 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 brassinolide results in decreased expression of CCND1 protein decreases expression
protein 20833159
C023623 898 CCNE1
CCNE
cyclin E1 brassinolide results in decreased expression of CCNE1 protein decreases expression
protein 20833159
C023623 1017 CDK2
p33(CDK2)
cyclin-dependent kinase 2 (EC:2.7.11.22) brassinolide results in decreased expression of CDK2 protein decreases expression
protein 20833159
C023623 1019 CDK4
CMM3
PSK-J3
cyclin-dependent kinase 4 (EC:2.7.11.22) brassinolide results in decreased expression of CDK4 protein decreases expression
protein 20833159
C023623 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) brassinolide results in increased expression of CDKN1A protein increases expression
protein 20833159
C023623 1027 CDKN1B
CDKN4
KIP1
MEN1B
MEN4
P27KIP1
cyclin-dependent kinase inhibitor 1B (p27, Kip1) brassinolide results in decreased expression of CDKN1B protein decreases expression
protein 20833159
C023623 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 brassinolide results in decreased expression of ESR1 decreases expression
20833159
C023623 2100 ESR2
ER-BETA
ESR-BETA
ESRB
ESTRB
Erb
NR3A2
estrogen receptor 2 (ER beta) brassinolide affects the localization of ESR2 protein affects localization
protein 20833159
C023623 2100 ESR2
ER-BETA
ESR-BETA
ESRB
ESTRB
Erb
NR3A2
estrogen receptor 2 (ER beta) brassinolide results in decreased expression of ESR2 decreases expression
20833159
C023623 4193 MDM2
ACTFS
HDMX
hdm2
MDM2 oncogene, E3 ubiquitin protein ligase brassinolide results in decreased expression of MDM2 protein decreases expression
protein 20833159
C023623 5925 RB1
OSRC
RB
p105-Rb
pRb
pp110
retinoblastoma 1 brassinolide results in decreased expression of RB1 protein decreases expression
protein 20833159
C023623 5925 RB1
OSRC
RB
p105-Rb
pRb
pp110
retinoblastoma 1 brassinolide results in decreased expression of RB1 protein modified form decreases expression
protein 20833159
C023623 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 brassinolide results in increased expression of TP53 protein increases expression
protein 20833159

Related Disease

Diseases related to CTD interactions

2 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D001943 C023623 Breast Neoplasms therapeutic
20833159
D011471 C023623 Prostatic Neoplasms therapeutic
17557751