Species

KNApSAcK Entry

Organism name Atalantia monophylla
Genus Atalantia
Family Rutaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Atalantia monophylla
Linked NCBI taxonomy ID 159025
Linked level species

Family

Family in NCBI taxonomy Rutaceae
ID 23513

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (14)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00013432 External link 512 Carpachromene
/ 5,4'-Dihidroxy-6'',6''-dimethylpyrano[2'',3'':7,6]flavone
/ 5-Hydroxy-8-(4-hydroxyphenyl)-2,2-dimethyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one
No. 24 No. 15
C00024249 External link 512 Citrusinine I
CHEMBL451705
C062044
1 / 0 / 0 No. 257 No. 7
C00029763 External link 512 Auraptene
CHEMBL307341
C105832
28 / 25 / 26 3 / 0 No. 335
C00033590 External link 512 6-Methoxyaurapten
/ 7-O-Geranylscopoletin
/ 6-Methoxy-7-geranyloxycoumarin
CHEMBL2346913
No. 335
C00024238 External link 512 Buxifoliadine A
No. 469 No. 7
C00024267 External link 512 N-Methylatalaphylline
No. 469 No. 7
C00002139 External link 512 Atalaphylline
No. 469 No. 7
C00024263 External link 512 Junosine
No. 469 No. 7
C00003103 External link 512 (+)-alpha-Bisabolol
CHEMBL519167
CHEMBL491186
CHEMBL477832
CHEMBL1096927
CHEMBL1171719
CHEMBL1561544
CHEMBL2104360
8 / 4 / 13 No. 541 No. 38
C00024242 External link 512 Buxifoliadine E
No. 1258
C00034078 External link 512 N-Methylbuxifoliadine E
No. 1258
C00033744 External link 512 Cycloatalaphylline A
No. 1258
C00024274 External link 512 Yukocitrine
No. 1724 No. 7
C00011895 External link 512 Norbisabolide
/ (R*,R*)-(+)-Dihydro-5-methyl-5-(4-methyl-3-cyclohexen-1-yl)-2(3H)-furanone
No. 6079

Human Protein / Gene in interactions

33 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P28482 Mitogen-activated protein kinase 1 Erk C00003103 C00029763 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00003103 C00029763 0 / 1
P16050 Arachidonate 15-lipoxygenase Enzyme C00003103 C00029763 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00003103 C00029763 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00029763 0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme C00029763 2 / 2
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00029763 2 / 0
O75496 Geminin Unclassified protein C00029763 0 / 0
P40763 Signal transducer and activator of transcription 3 Transcription Factor C00003103 1 / 2
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00029763 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00029763 1 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00029763 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00029763 0 / 0
Q13315 Serine-protein kinase ATM Atypical serine/threonine protein kinase PIKK subfamily C00029763 1 / 4
P06280 Alpha-galactosidase A Enzyme C00029763 1 / 1
Q96RI1 Bile acid receptor NR1H4 C00029763 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00029763 0 / 0
P56817 Beta-secretase 1 A1A C00029763 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00029763 3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00029763 2 / 2
P04062 Glucosylceramidase Enzyme C00029763 6 / 4
O60911 Cathepsin L2 C1A C00024249 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00003103 0 / 3
O75164 Lysine-specific demethylase 4A Enzyme C00029763 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00029763 4 / 3
B2RXH2 Lysine-specific demethylase 4E Enzyme C00029763 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00029763 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00029763 1 / 1
O00255 Menin Unclassified protein C00003103 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00003103 1 / 2
Q13951 Core-binding factor subunit beta Unclassified protein C00029763 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00029763 1 / 4
Q13148 TAR DNA-binding protein 43 Unclassified protein C00029763 1 / 1

3 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00029763
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00029763
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00029763

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (29)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#208900 Ataxia-telangiectasia; at Q13315
#114500 Colorectal cancer; crc P84022
#119900 Digital clubbing, isolated congenital P15428
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#147060 Hyper-ige recurrent infection syndrome, autosomal dominant P40763
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (37)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00125 Fabry disease P06280 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00016 Oral cancer P40763 (related)
H00107 Other well-defined immunodeficiency syndromes P40763 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00005 Chronic lymphocytic leukemia (CLL) Q13315 (related)
H00064 Ataxia telangiectasia (AT) Q13315 (related)
H00094 DNA repair defects Q13315 (related)
H00848 Ataxia with ocular apraxia (AOA) Q13315 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)