Species

KNApSAcK Entry

Organism name Persea americana
Genus Persea
Family Lauraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Persea americana
Linked NCBI taxonomy ID 3435
Linked level species

Family

Family in NCBI taxonomy Lauraceae
ID 3433

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Magnoliophyta
ID 3398

Metabolite list (13)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00013736 External link 512 Kaempferol 3-alpha-D-arabinopyranoside
/ 3-(alpha-D-Arabinopyranosyloxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
CHEMBL518420
CHEMBL477730
No. 2 No. 15
C00013833 External link 512 Quercetin 3-O-alpha-D-arabinopyranoside
/ 3-(alpha-D-Arabinopyranosyloxy)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one
CHEMBL183031
CHEMBL185461
CHEMBL488198
CHEMBL464507
CHEMBL520637
No. 2 No. 15
C00003770 External link 512 alpha-Cryptoxanthin
No. 26 No. 59
C00001156 External link 512 D-Arabitol
CHEMBL96783
CHEMBL1369426
CHEMBL1865120
1 / 0 / 0 No. 630
C00001167 External link 512 Perseitol
CHEMBL1597273
C025642
3 / 1 / 1 No. 630
C00023109 External link 512 3-Hydroxysintaxanthin
No. 747
C00002644 External link 512 Catechol
/ Pyrocatechol
CHEMBL280998
C034221
148 / 82 / 64 22 / 5 No. 1590 No. 82
C00029504 External link 512 Vanilacetic acid
/ Homovanillic acid
/ 3-Methoxy-4-hydroxyphenylacetic acid
/ 4-Hydroxy-3-methoxybenzeneacetic acid
CHEMBL1562
D006719
17 / 9 / 7 2 / 11 No. 1852 No. 6
C00000207 External link 512 Benzoic acid
CHEMBL541
D019817
97 / 39 / 33 24 / 1 No. 2192
C00001125 External link 512 alpha-D-Mannoheptulose
CHEMBL320826
CHEMBL134846
CHEMBL2068676
CHEMBL2303667
CHEMBL2303800
3 / 1 / 1 No. 2228
C00029471 External link 512 4-Hydroxydihydrocinnamic acid
/ 3-(4-Hydroxyphenyl)propionic acid
CHEMBL1172560
C008869
1 / 2 / 0 No. 3466
C00041084 External link 512 Persin
/ (+)-Persin
CHEMBL465370
CHEMBL464979
No. 4918
C00030483 External link 512 Hippuric acid
CHEMBL461
C030514
8 / 15 / 14 No. 7440

Human Protein / Gene in interactions

169 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000207 C00002644 C00029504 1 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000207 C00002644 C00029504 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00001167 C00002644 C00029504 1 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000207 C00002644 C00029504 0 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00001156 C00001167 C00002644 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000207 C00002644 C00029504 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000207 C00002644 C00029504 0 / 1
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00000207 C00002644 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00000207 C00002644 1 / 1
P21728 D(1A) dopamine receptor Dopamine receptor C00000207 C00002644 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000207 C00002644 0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00000207 C00002644 2 / 2
P08246 Neutrophil elastase S1A C00000207 C00002644 2 / 1
P33765 Adenosine receptor A3 Adenosine receptor C00000207 C00002644 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00000207 C00002644 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00000207 C00002644 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00000207 C00002644 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00000207 C00002644 0 / 0
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00000207 C00002644 0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00000207 C00002644 1 / 1
P19224 UDP-glucuronosyltransferase 1-6 Enzyme C00000207 C00029504 0 / 0
Q99549 M-phase phosphoprotein 8 Unclassified protein C00002644 C00029504 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001167 C00002644 0 / 0
P29466 Caspase-1 C14 C00000207 C00002644 0 / 0
P17252 Protein kinase C alpha type Alpha C00000207 C00002644 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00000207 C00002644 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00000207 C00002644 2 / 2
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00000207 C00002644 0 / 0
P06239 Tyrosine-protein kinase Lck Src C00000207 C00002644 0 / 1
P02545 Prelamin-A/C Unclassified protein C00002644 C00030483 11 / 10
P16473 Thyrotropin receptor Glycohormone receptor C00000207 C00029504 3 / 2
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00000207 C00002644 0 / 0
P00918 Carbonic anhydrase 2 Lyase C00000207 C00002644 1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00000207 C00002644 0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00000207 C00002644 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00000207 C00002644 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00000207 C00002644 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00000207 C00002644 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00000207 C00002644 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00000207 C00002644 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00000207 C00002644 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00002644 C00029504 0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00000207 C00002644 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00000207 C00002644 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00000207 C00002644 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00000207 C00002644 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00002644 C00029504 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00000207 C00002644 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00000207 C00002644 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00000207 C00002644 0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00000207 C00002644 1 / 8
P14416 D(2) dopamine receptor Dopamine receptor C00000207 C00002644 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00000207 C00002644 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00000207 C00002644 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00000207 C00002644 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00000207 C00002644 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00000207 C00002644 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00000207 C00002644 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00000207 C00002644 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00000207 C00002644 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00000207 C00002644 1 / 1
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00000207 C00002644 0 / 0
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00000207 C00002644 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00000207 C00002644 1 / 0
P22303 Acetylcholinesterase Hydrolase C00000207 C00002644 1 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00002644 C00029504 0 / 0
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00000207 C00002644 1 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00000207 C00002644 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00000207 C00002644 0 / 0
P03372 Estrogen receptor NR3A1 C00000207 C00002644 1 / 1
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00000207 C00002644 2 / 1
P28482 Mitogen-activated protein kinase 1 Erk C00000207 C00002644 0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00000207 C00002644 1 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00000207 C00002644 0 / 0
O60656 UDP-glucuronosyltransferase 1-9 Enzyme C00000207 C00029504 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00000207 C00002644 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00002644 C00029504 2 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00000207 C00002644 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00000207 C00002644 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00000207 C00002644 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00000207 C00002644 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00000207 C00002644 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00000207 C00002644 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00000207 C00002644 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00000207 C00002644 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00000207 C00002644 3 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00000207 C00002644 1 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00000207 C00002644 0 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00000207 C00002644 0 / 0
P08311 Cathepsin G S1A C00000207 C00002644 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00000207 C00002644 1 / 0
P03956 Interstitial collagenase M10A C00000207 C00002644 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00000207 C00002644 0 / 0
P21452 Substance-K receptor Neurokinin receptor C00000207 C00002644 0 / 0
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00000207 C00002644 1 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00000207 C00002644 5 / 9
P31645 Sodium-dependent serotonin transporter Serotonin C00000207 C00002644 2 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00002644 C00029504 0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00000207 C00002644 0 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00000207 C00002644 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00000207 C00002644 0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00000207 C00002644 2 / 0
P11217 Glycogen phosphorylase, muscle form Enzyme C00001125 1 / 1
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00002644 0 / 0
Q4U2R8 Solute carrier family 22 member 6 Antiporter C00030483 0 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00002644 5 / 3
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00002644 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00002644 1 / 1
Q9GZT4 Serine racemase Enzyme C00000207 0 / 0
P00915 Carbonic anhydrase 1 Lyase C00002644 0 / 0
P10145 Interleukin-8 Secreted protein C00002644 0 / 0
Q8TCC7 Solute carrier family 22 member 8 Antiporter C00030483 0 / 0
Q96RI1 Bile acid receptor NR1H4 C00002644 0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00002644 0 / 0
O75496 Geminin Unclassified protein C00002644 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00030483 2 / 0
P39748 Flap endonuclease 1 Enzyme C00002644 0 / 0
Q16790 Carbonic anhydrase 9 Lyase C00002644 0 / 1
P08253 72 kDa type IV collagenase M10A C00002644 1 / 3
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00002644 3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00002644 2 / 2
O15118 Niemann-Pick C1 protein Unclassified protein C00002644 1 / 1
Q01453 Peripheral myelin protein 22 Unclassified protein C00002644 5 / 2
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00002644 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00029504 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00002644 0 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein C00002644 0 / 0
O43570 Carbonic anhydrase 12 Lyase C00002644 1 / 2
Q9ULX7 Carbonic anhydrase 14 Lyase C00002644 0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme C00002644 0 / 0
P11216 Glycogen phosphorylase, brain form Enzyme C00001125 0 / 0
P23280 Carbonic anhydrase 6 Lyase C00002644 0 / 0
P54132 Bloom syndrome protein Enzyme C00002644 1 / 2
Q9GZT9 Egl nine homolog 1 Enzyme C00002644 1 / 1
P14920 D-amino-acid oxidase Enzyme C00000207 0 / 0
P26358 DNA (cytosine-5)-methyltransferase 1 Transferase C00029471 2 / 0
Q9UQ49 Sialidase-3 Enzyme C00000207 0 / 0
P08183 Multidrug resistance protein 1 drug C00030483 1 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00002644 0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00002644 1 / 1
Q99489 D-aspartate oxidase Enzyme C00000207 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00002644 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00002644 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00002644 0 / 0
P22894 Neutrophil collagenase M10A C00002644 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00002644 4 / 3
P43166 Carbonic anhydrase 7 Lyase C00002644 0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00002644 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00002644 0 / 0
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00002644 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00029504 1 / 1
Q16719 Kynureninase Enzyme C00030483 0 / 0
P06746 DNA polymerase beta Enzyme C00002644 0 / 0
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00002644 0 / 0
P07451 Carbonic anhydrase 3 Lyase C00002644 0 / 0
Q99700 Ataxin-2 Unclassified protein C00002644 1 / 1
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein C00000207 0 / 0
P08254 Stromelysin-1 M10A C00002644 1 / 0
P22748 Carbonic anhydrase 4 Lyase C00002644 1 / 1
Q16637 Survival motor neuron protein Unclassified protein C00002644 4 / 1
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002644 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00002644 0 / 0
P40225 Thrombopoietin Unclassified protein C00002644 1 / 1
P10323 Acrosin S1A C00001125 0 / 0
P42345 Serine/threonine-protein kinase mTOR Enzyme C00002644 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00002644 1 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00030483 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00030483 1 / 4
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00002644 0 / 0

46 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1312 COMT catechol-O-methyltransferase (EC:2.1.1.6) C00002644 C00029504
1728 NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1 NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) C00000207 C00002644
231 AKR1B1, ADR, ALDR1, ALR2, AR aldo-keto reductase family 1, member B1 (aldose reductase) (EC:1.1.1.21) C00000207
6356 CCL11, SCYA11 chemokine (C-C motif) ligand 11 C00002644
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00002644
6348 CCL3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3 chemokine (C-C motif) ligand 3 C00002644
6351 CCL4, ACT2, AT744.1, G-26, HC21, LAG-1, LAG1, MIP-1-beta, MIP1B, MIP1B1, SCYA2, SCYA4 chemokine (C-C motif) ligand 4 C00002644
6352 CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP chemokine (C-C motif) ligand 5 C00002644
212 ALAS2, ALAS-E, ALASE, ANH1, ASB, XLDPP, XLEPP, XLSA aminolevulinate, delta-, synthase 2 (EC:2.3.1.37) C00002644
1571 CYP2E1, CPE1, CYP2E, P450-J, P450C2E cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) C00002644
2623 GATA1, ERYF1, GATA-1, GF-1, GF1, NF-E1, NFE1, XLANP, XLTDA, XLTT GATA binding protein 1 (globin transcription factor 1) C00002644
3043 HBB, CD113t-C, beta-globin hemoglobin, beta C00002644
3145 HMBS, PBG-D, PBGD, PORC, UPS hydroxymethylbilane synthase (EC:2.5.1.61) C00002644
3586 IL10, CSIF, GVHDS, IL-10, IL10A, TGIF interleukin 10 C00002644
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00002644
4609 MYC, MRTL, MYCC, bHLHe39, c-Myc v-myc avian myelocytomatosis viral oncogene homolog C00002644
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00002644
6817 SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) C00002644
6799 SULT1A2, HAST4, P-PST, ST1A2, STP2, TSPST2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 (EC:2.8.2.1) C00002644
6818 SULT1A3, HAST, HAST3, M-PST, ST1A3/ST1A4, ST1A5, STM, TL-PST sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC:2.8.2.1) C00002644
6819 SULT1C2, ST1C1, ST1C2, SULT1C1, humSULTC2 sulfotransferase family, cytosolic, 1C, member 2 (EC:2.8.2.-) C00002644
7037 TFRC, CD71, T9, TFR, TFR1, TR, TRFR, p90 transferrin receptor C00002644
6343 SCT secretin C00029504
840 CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) C00002644
57016 AKR1B10, AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HSI aldo-keto reductase family 1, member B10 (aldose reductase) (EC:1.1.1.2) C00000207
1645 AKR1C1, 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB aldo-keto reductase family 1, member C1 (EC:1.3.1.20 1.1.1.149 1.1.1.112) C00000207
8644 AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) C00000207
2235 FECH, EPP, FCE ferrochelatase (EC:4.99.1.1) C00000207
2512 FTL, NBIA3 ferritin, light polypeptide C00000207
2539 G6PD, G6PD1 glucose-6-phosphate dehydrogenase (EC:1.1.1.49) C00000207
2729 GCLC, GCL, GCS, GLCL, GLCLC glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) C00000207
2730 GCLM, GLCLR glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2) C00000207
2936 GSR glutathione reductase (EC:1.8.1.7) C00000207
2938 GSTA1, GST2, GSTA1-1, GTH1 glutathione S-transferase alpha 1 (EC:2.5.1.18) C00000207
3162 HMOX1, HMOX1D, HO-1, HSP32, bK286B10 heme oxygenase (decycling) 1 (EC:1.14.99.3) C00000207
4097 MAFG, hMAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G C00000207
4199 ME1, HUMNDME, MES malic enzyme 1, NADP(+)-dependent, cytosolic (EC:1.1.1.40) C00000207
4489 MT1A, MT1, MT1S, MTC metallothionein 1A C00000207
4502 MT2A, MT2 metallothionein 2A C00000207
4846 NOS3, ECNOS, eNOS nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) C00000207
5226 PGD, 6PGD phosphogluconate dehydrogenase (EC:1.1.1.44) C00000207
22949 PTGR1, LTB4DH, PGR1, ZADH3 prostaglandin reductase 1 (EC:1.3.1.48 1.3.1.74) C00000207
6566 SLC16A1, HHF7, MCT, MCT1 solute carrier family 16 (monocarboxylate transporter), member 1 C00000207
140809 SRXN1, C20orf139, Npn3, SRX, SRX1 sulfiredoxin 1 (EC:1.8.98.2) C00000207
7295 TXN, TRDX, TRX, TRX1 thioredoxin C00000207
7296 TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR thioredoxin reductase 1 (EC:1.8.1.9) C00000207

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (93)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#210900 Bloom syndrome; blm P54132
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
%606641 Body mass index; bmi P37231
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#604121 Cerebellar ataxia, deafness, and narcolepsy, autosomal dominant; adcadn P26358
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#114500 Colorectal cancer; crc P84022
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#609820 Erythrocytosis, familial, 3; ecyt3 Q9GZT9
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 O75874
P04626
P37231
#232300 Glycogen storage disease ii P10253
#232600 Glycogen storage disease v P11217
#139393 Guillain-barre syndrome, familial; gbs Q01453
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#143860 Hyperchlorhidrosis, isolated O43570
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
%300852 Mental retardation, x-linked 88; mrx88 P50052
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#614116 Neuropathy, hereditary sensory, type ie; hsn1e P26358
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#257220 Niemann-pick disease, type c1; npc1 O15118
#601665 Obesity P32245
P37231
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#600852 Retinitis pigmentosa 17; rp17 P22748
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#187950 Thrombocythemia 1; thcyt1 P40225
#190300 Tremor, hereditary essential, 1; etm1 P35462
#610379 West nile virus, susceptibility to P51681
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253
#112100 Yt blood group antigen P22303

KEGG DISEASE (71)

KEGG name UniProt
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
P08253 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
P35354 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
P11217 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00192 Xanthinuria P47989 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
Q99714 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00236 Congenital polycythemia Q9GZT9 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

16 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D012640 Seizures C00002644
C00029504
D006816 Huntington Disease C00029504
D009784 Occupational Diseases C00002644
D011041 Poisoning C00002644
D002869 Chromosome Aberrations C00002644
D001927 Brain Diseases C00029504
D002375 Catalepsy C00029504
D064420 Drug-Related Side Effects and Adverse Reactions C00029504
D048629 Micronuclei, Chromosome-Defective C00002644
D006948 Hyperkinesis C00029504
D010302 Parkinson Disease, Secondary C00029504
D020734 Parkinsonian Disorders C00029504
C537537 Segawa syndrome, autosomal recessive C00029504
D013226 Status Epilepticus C00029504
D019956 Stereotypic Movement Disorder C00029504
D003877 Dermatitis, Contact C00000207