Eschscholzia californica
Species
KNApSAcK Entry
| Organism name | Eschscholzia californica |
|---|---|
| Genus | Eschscholzia |
| Family | Papaveraceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Eschscholzia californica |
|---|---|
| Linked NCBI taxonomy ID | 3467 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Papaveraceae |
|---|---|
| ID | 3465 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | eudicotyledons |
|---|---|
| ID | 71240 |
Natural Activity
List (14)
| Species | Activity |
|---|---|
| Eschscholzia californica Cham. | Analgesic |
| Eschscholzia californica Cham. | Antispasmodic |
| Eschscholzia californica Cham. | Anxiolytic |
| Eschscholzia californica Cham. | Calmative |
| Eschscholzia californica Cham. | Diaphoretic |
| Eschscholzia californica Cham. | Diuretic |
| Eschscholzia californica Cham. | Emetic |
| Eschscholzia californica Cham. | Lactifuge |
| Eschscholzia californica Cham. | Narcotic |
| Eschscholzia californica Cham. | Piscicide |
| Eschscholzia californica Cham. | Poison |
| Eschscholzia californica Cham. | Sedative |
| Eschscholzia californica Cham. | Soporitic |
| Eschscholzia californica Cham. | Uterotonic |
Metabolite list (16)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00002525
|
Formononetin
/ 7-Hydroxy-4'-methoxyisoflavone |
CHEMBL242341
|
C007768
|
24 / 36 / 58 | 13 / 0 | No. 3 | No. 15 |
|
|
C00019506
|
2',4'-Dihydroxy-7-methoxyisoflavone
|
No. 3 | No. 15 |
|
||||
|
C00013989
|
3,5,6,7,8,4'-Hexahydroxy-3'-methoxyflavone 3-rhamnosyl-(1->4)-rhamnosyl-(1->6)-glucoside
/ 3-[(O-6-Deoxy-alpha-L-mannopyranosyl-(1->4)-O-6-deoxy-alpha-L-mannopyranosyl-(1->6)-beta-D-glucopyranosyl)oxy]-5,6,7,8-tetrahydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-1-benzopyran-4-one |
No. 5 | No. 15 |
|
||||
|
C00025675
|
Lauroscholtzine
/ 2-O-Methylboldine / N-Methyllaurotetanine / (+)-N-Methyllaurotetanine |
CHEMBL464099
|
1 / 1 / 0 | No. 20 | No. 4 |
|
||
|
C00003771
|
Eschscholtzxanthin
|
No. 26 | No. 59 |
|
||||
|
C00019505
|
7-Hydroxy-2',4'-dimethoxyisoflavone
|
CHEMBL1087126
|
5 / 5 / 6 | No. 35 | No. 15 |
|
||
|
C00019507
|
7,2',4'-Trimethoxyisoflavone
|
No. 35 | No. 15 |
|
||||
|
C00001855
|
Eschscholtzidine
/ O-Methylcaryachine |
CHEMBL1621815
|
No. 37 | No. 4 |
|
|||
|
C00009383
|
2'-Hydroxydaidzein
/ 7,2',4'-Trihydroxyisoflavone |
CHEMBL6694
|
No. 71 | No. 15 |
|
|||
|
C00003760
|
Antheraxanthin
/ (3R,5R,6S,3'R)-zeaxanthin 5,6-epoxide |
C031140
|
No. 114 | No. 59 |
|
|||
|
C00003787
|
Violaxanthin
|
C005613
|
No. 114 | No. 59 |
|
|||
|
C00001847
|
Dihydrosanguinarine
|
CHEMBL465678
|
No. 195 | No. 4 |
|
|||
|
C00022920
|
(3S,3'S,5'R)-4,5'-Retro-beta,beta-Carotene-3,3',5'-triol
|
No. 394 |
|
|||||
|
C00041411
|
Californidine
|
No. 526 |
|
|||||
|
C00000218
|
Jasmonic acid
/ trans-Jasmonic acid / 3-Oxo-2-(2Z-pentenyl)cyclotentylacetic acid |
CHEMBL445499
CHEMBL449572 |
C011006
|
4 / 1 / 0 | No. 707 | No. 70 |
|
|
|
C00000219
|
Methyl jasmonate
|
CHEMBL184827
CHEMBL461150 CHEMBL2139332 |
C072239
|
No. 3198 |
|
Human Protein / Gene in interactions
29 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002525 C00019505 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002525 C00019505 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002525 C00019505 | 0 / 1 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00002525 C00019505 | 2 / 2 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00002525 C00019505 | 3 / 3 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00002525 | 5 / 3 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00002525 | 4 / 1 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00002525 | 0 / 0 |
| P04798 | Cytochrome P450 1A1 | Cytochrome P450 1A1 | C00002525 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00002525 | 0 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00002525 | 1 / 0 |
| P42330 | Aldo-keto reductase family 1 member C3 | Enzyme | C00000218 | 0 / 0 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00002525 | 4 / 2 |
| P11021 | 78 kDa glucose-regulated protein | Unclassified protein | C00002525 | 0 / 0 |
| P17516 | Aldo-keto reductase family 1 member C4 | Enzyme | C00000218 | 1 / 0 |
| P31639 | Sodium/glucose cotransporter 2 | Glucose | C00002525 | 1 / 1 |
| Q04828 | Aldo-keto reductase family 1 member C1 | Enzyme | C00000218 | 0 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00002525 | 7 / 37 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00002525 | 1 / 1 |
| P13866 | Sodium/glucose cotransporter 1 | Glucose | C00002525 | 1 / 1 |
| P52895 | Aldo-keto reductase family 1 member C2 | Enzyme | C00000218 | 1 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00002525 | 4 / 3 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00002525 | 0 / 0 |
| P08908 | 5-hydroxytryptamine receptor 1A | Serotonin receptor | C00025675 | 1 / 0 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00002525 | 0 / 0 |
| P33527 | Multidrug resistance-associated protein 1 | drugs | C00002525 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00002525 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00002525 | 1 / 2 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00002525 | 0 / 0 |
13 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 5243 | ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) |
C00002525
|
| 4363 | ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 |
C00002525
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00002525
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00002525
|
| 2056 | EPO, EP, MVCD2 | erythropoietin |
C00002525
|
| 2099 | ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 | estrogen receptor 1 |
C00002525
|
| 2100 | ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 | estrogen receptor 2 (ER beta) |
C00002525
|
| 3091 | HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) |
C00002525
|
| 54658 | UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A | UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) |
C00002525
|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00002525
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00002525
|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00002525
|
| 54600 | UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I | UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) |
C00002525
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (38)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #614279 | 46,xy sex reversal 8; srxy8 |
P17516
P52895 |
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| %606641 | Body mass index; bmi |
P37231
|
| #114480 | Breast cancer |
P38398
|
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #133239 | Esophageal cancer |
P04637
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #137800 | Glioma susceptibility 1; glm1 |
P37231
|
| #606824 | Glucose/galactose malabsorption; ggm |
P13866
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #211980 | Lung cancer |
P04637
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #601665 | Obesity |
P37231
|
| #167000 | Ovarian cancer |
P38398
|
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #614674 | Periodic fever, menstrual cycle-dependent |
P08908
|
| #172700 | Pick disease of brain |
P10636
|
| #233100 | Renal glucosuria; glys1 |
P31639
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
KEGG DISEASE (58)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
P38398 (related) |
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
P38398 (related) |
| H00032 | Thyroid cancer |
P04637
(related)
P37231 (related) |
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H01261 | Congenital glucose-galactose malabsorption (GGM) |
P13866
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H01126 | Familial renal glucosuria (FRG) |
P31639
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P37231
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|