Cleidion spiciflorum (Burm. f.) Merr.
Species
KNApSAcK Entry
| Organism name | Cleidion spiciflorum (Burm. f.) Merr. |
|---|---|
| Genus | Cleidion |
| Family | Euphorbiaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Cleidion |
|---|---|
| Linked NCBI taxonomy ID | 212289 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Euphorbiaceae |
|---|---|
| ID | 3977 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (11)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00032287
|
Taraxerone
|
CHEMBL519077
CHEMBL1990874 |
C009379
|
No. 13 | No. 51 |
|
||
|
C00023774
|
Fucostanol
/ Stigmasterol / Dihydro-beta-sitosterol / (24S)24-Ethylcholestain-3beta-ol |
CHEMBL66943
CHEMBL186373 CHEMBL400247 CHEMBL1568947 |
D013265
|
5 / 0 / 0 | 1 / 0 | No. 53 | No. 11 |
|
|
C00003672
|
Sitosterol
/ beta-sitosterl / (-)-beta-Sitosterol / Stigmast-5-en-3beta-ol |
CHEMBL221542
CHEMBL1398443 CHEMBL1875388 |
17 / 19 / 12 | No. 53 | No. 11 |
|
||
|
C00034781
|
Acetylaleuritolic acid
/ 3-Acetyl aleuritolic acid / (+)-Aleuritolic acid acetate / (+)-3-Acetyl aleuritolic acid |
CHEMBL439422
|
C014947
|
No. 177 |
|
|||
|
C00033565
|
Acetyloleanolic acid
/ Oleanolic acid acetate / 3-O-Acetyloleanolic acid / (+)-Acetyloleanolic acid / (+)-Oleanolic acid acetate / (+)-3-O-Acetyloleanolic acid / 3beta-Acetoxyolean-12-en-28-oic acid |
CHEMBL486822
CHEMBL494653 CHEMBL1315416 |
C052658
|
1 / 0 / 0 | No. 177 |
|
||
|
C00002499
|
Scopoletin
|
CHEMBL71851
|
D012603
|
48 / 37 / 34 | 9 / 0 | No. 864 | No. 25 |
|
|
C00002674
|
Syringic acid
/ 4-Hydroxy-3,5-dimethoxybenzoic acid |
CHEMBL1414
|
C001945
|
12 / 3 / 5 | No. 1073 |
|
||
|
C00002682
|
Vanillic acid
/ 3-Methoxy-4-hydroxybenzoic acid |
CHEMBL120568
|
D014641
|
5 / 3 / 3 | 5 / 0 | No. 1073 |
|
|
|
C00034895
|
Spiciflorin
/ (-)-Spiciflorin |
No. 1330 | No. 43 |
|
||||
|
C00003417
|
Columbin
|
CHEMBL1417543
|
C062514
|
3 / 5 / 4 | No. 2453 | No. 43 |
|
|
|
C00034907
|
trans-4-Hydroxy-N-methyl-L-proline
/ (-)-trans-4-Hydroxy-N-methyl-L-proline |
No. 5329 |
|
Human Protein / Gene in interactions
75 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P15121 | Aldose reductase | Enzyme | C00002499 C00002674 C00002682 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00002499 C00003672 | 0 / 0 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00002499 C00003672 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002499 C00003672 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00002499 C00003672 | 1 / 1 |
| P03372 | Estrogen receptor | NR3A1 | C00002682 C00003672 | 1 / 1 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00002499 C00002674 | 0 / 1 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00003417 C00003672 | 1 / 1 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00002499 C00002674 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00003672 C00023774 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00002499 C00003672 | 1 / 0 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00002499 C00002674 | 1 / 2 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00002499 C00003672 | 0 / 1 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00002499 C00002674 | 1 / 2 |
| P43166 | Carbonic anhydrase 7 | Lyase | C00002499 C00002674 | 0 / 0 |
| Q00796 | Sorbitol dehydrogenase | Enzyme | C00002499 | 0 / 0 |
| P04406 | Glyceraldehyde-3-phosphate dehydrogenase | Enzyme | C00002499 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00002499 | 0 / 0 |
| Q8N1Q1 | Carbonic anhydrase 13 | Lyase | C00002499 | 0 / 0 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00033565 | 0 / 0 |
| P55789 | FAD-linked sulfhydryl oxidase ALR | Enzyme | C00002499 | 1 / 0 |
| P08047 | Transcription factor Sp1 | Unclassified protein | C00003672 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00003672 | 3 / 2 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00002499 | 1 / 1 |
| P35218 | Carbonic anhydrase 5A, mitochondrial | Lyase | C00002674 | 0 / 0 |
| P34969 | 5-hydroxytryptamine receptor 7 | Serotonin receptor | C00023774 | 0 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | C00003672 | 1 / 0 |
| Q9Y2D0 | Carbonic anhydrase 5B, mitochondrial | Lyase | C00002674 | 0 / 0 |
| P23280 | Carbonic anhydrase 6 | Lyase | C00002674 | 0 / 0 |
| Q9ULX7 | Carbonic anhydrase 14 | Lyase | C00002674 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002499 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00002499 | 1 / 1 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00002499 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00002499 | 0 / 0 |
| P42858 | Huntingtin | Unclassified protein | C00002682 | 1 / 1 |
| O75496 | Geminin | Unclassified protein | C00002499 | 0 / 0 |
| O60656 | UDP-glucuronosyltransferase 1-9 | Enzyme | C00002499 | 0 / 0 |
| P54855 | UDP-glucuronosyltransferase 2B15 | Enzyme | C00002499 | 0 / 0 |
| P04062 | Glucosylceramidase | Enzyme | C00002499 | 6 / 4 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00002499 | 0 / 3 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00003672 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00002499 | 7 / 3 |
| Q04206 | Transcription factor p65 | Transcription Factor | C00002499 | 0 / 0 |
| P00734 | Prothrombin | S1A | C00003672 | 4 / 2 |
| P14679 | Tyrosinase | Oxidoreductase | C00003672 | 4 / 2 |
| P06280 | Alpha-galactosidase A | Enzyme | C00002499 | 1 / 1 |
| P09917 | Arachidonate 5-lipoxygenase | Oxidoreductase | C00002499 | 0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00003672 | 2 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00002499 | 3 / 3 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00002499 | 2 / 2 |
| Q9HAW9 | UDP-glucuronosyltransferase 1-8 | Enzyme | C00002499 | 0 / 0 |
| Q9Y4X1 | UDP-glucuronosyltransferase 2A1 | Enzyme | C00002499 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00002499 | 1 / 1 |
| P09884 | DNA polymerase alpha catalytic subunit | Transferase | C00023774 | 0 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00002499 | 1 / 0 |
| P29466 | Caspase-1 | C14 | C00002499 | 0 / 0 |
| P55210 | Caspase-7 | C14 | C00002499 | 0 / 0 |
| P51580 | Thiopurine S-methyltransferase | Enzyme | C00002682 | 1 / 1 |
| Q9HAW8 | UDP-glucuronosyltransferase 1-10 | Enzyme | C00002499 | 0 / 0 |
| O75795 | UDP-glucuronosyltransferase 2B17 | Enzyme | C00002499 | 1 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00002682 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00003417 | 0 / 0 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00002499 | 5 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00003417 | 4 / 3 |
| P07451 | Carbonic anhydrase 3 | Lyase | C00002674 | 0 / 0 |
| P22748 | Carbonic anhydrase 4 | Lyase | C00002674 | 1 / 1 |
| P80365 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | C00003672 | 1 / 1 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002499 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00002499 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00002499 | 0 / 0 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00002499 | 3 / 0 |
| O00255 | Menin | Unclassified protein | C00002499 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00002499 | 1 / 2 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00023774 | 0 / 0 |
| Q02880 | DNA topoisomerase 2-beta | Isomerase | C00023774 | 0 / 0 |
11 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00002499
C00002682
|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00002499
C00002682
|
| 54659 | UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C | UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) |
C00002499
C00002682
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00002499
C00002682
|
| 54658 | UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A | UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) |
C00002499
|
| 54578 | UGT1A6, GNT1, HLUGP, HLUGP1, UDPGT, UDPGT_1-6, UGT1, UGT1A6S, UGT1F | UDP glucuronosyltransferase 1 family, polypeptide A6 (EC:2.4.1.17) |
C00002499
|
| 54600 | UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I | UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) |
C00002499
|
| 7366 | UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8 | UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) |
C00002499
|
| 7508 | XPC, RAD4, XP3, XPCC | xeroderma pigmentosum, complementation group C |
C00002499
|
| 10599 | SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6 | solute carrier organic anion transporter family, member 1B1 |
C00023774
|
| 4846 | NOS3, ECNOS, eNOS | nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) |
C00002682
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (61)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #218030 | Apparent mineralocorticoid excess; ame |
P80365
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #612560 | Bone mineral density quantitative trait locus 12; bmnd12 |
O75795
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
| #606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #301500 | Fabry disease |
P06280
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #143500 | Gilbert syndrome |
P22309
P22310 |
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #143100 | Huntington disease; hd |
P42858
|
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613076 | Myopathy, mitochondrial progressive, with congenital cataract, hearing loss, and developmental delay |
P55789
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #614390 | Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 |
P00734
|
| #613679 | Prothrombin deficiency, congenital |
P00734
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #600852 | Retinitis pigmentosa 17; rp17 |
P22748
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601367 | Stroke, ischemic |
P00734
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #610460 | Thiopurine s-methyltransferase deficiency |
P51580
|
| #188050 | Thrombophilia due to thrombin defect; thph1 |
P00734
|
| #278300 | Xanthinuria, type i |
P47989
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (48)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
Q16790 (marker) |
| H00223 | Inherited thrombophilia |
P00734
(related)
|
| H01254 | Congenital prothrombin deficiency |
P00734
(related)
|
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
|
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00125 | Fabry disease |
P06280
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00038 | Malignant melanoma |
P14679
(marker)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H00527 | Retinitis pigmentosa (RP) |
P22748
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00017 | Esophageal cancer |
P35354
(related)
|
| H00025 | Penile cancer |
P35354
(related)
|
| H00046 | Cholangiocarcinoma |
P35354
(related)
|
| H00059 | Huntington's disease (HD) |
P42858
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00964 | Thiopurine S-methyltransferase deficiency (TPMT deficiency) |
P51580
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00259 | Apparent mineralocorticoid excess syndrome |
P80365
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|