Piper solmsianum
Species
KNApSAcK Entry
| Organism name | Piper solmsianum |
|---|---|
| Genus | Piper |
| Family | Piperaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Piper solmsianum |
|---|---|
| Linked NCBI taxonomy ID | 538350 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Piperaceae |
|---|---|
| ID | 16739 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | Magnoliophyta |
|---|---|
| ID | 3398 |
Metabolite list (8)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00002607
|
Grandisin
/ (-)-Grandisin |
CHEMBL459404
CHEMBL459405 CHEMBL1377609 CHEMBL2204392 |
C074346
|
4 / 3 / 7 | No. 38 | No. 21 |
|
|
|
C00023770
|
Sitosterol
/ Stigmasta-5,22-dien-3beta-ol / (24R)24-Ethylcholesta-5,22-dien-3beta-ol |
CHEMBL221542
CHEMBL1398443 CHEMBL1875388 |
17 / 19 / 12 | No. 53 | No. 11 |
|
||
|
C00002739
|
Elemicin
|
CHEMBL458690
|
C002135
|
No. 723 | No. 6 |
|
||
|
C00031898
|
Isoelemicin
/ (E)-Isoelemicin |
CHEMBL121548
|
No. 723 | No. 6 |
|
|||
|
C00007558
|
Syringaldehyde
/ 4-Hydroxy-3,5-dimethoxybenzaldehyde |
CHEMBL225303
|
C069665
|
No. 856 |
|
|||
|
C00029476
|
Eudesmic acid
/ Trimethylgallic acid / 3,4,5-Trimethoxybenzoic acid |
CHEMBL377172
|
C005854
|
3 / 2 / 2 | No. 1073 |
|
||
|
C00002714
|
Apiol
/ Apiole / Parsley apiole |
CHEMBL1560118
|
3 / 0 / 1 | No. 1917 | No. 6 |
|
||
|
C00002762
|
Myristicin
|
CHEMBL481044
|
C005246
|
6 / 4 / 2 | 2 / 0 | No. 1917 | No. 6 |
|
Human Protein / Gene in interactions
28 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| O75496 | Geminin | Unclassified protein | C00002607 C00002762 C00029476 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002714 C00002762 C00023770 | 0 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00002607 C00002762 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00002714 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00023770 | 0 / 0 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00002762 | 0 / 0 |
| P08047 | Transcription factor Sp1 | Unclassified protein | C00023770 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00023770 | 3 / 2 |
| P08183 | Multidrug resistance protein 1 | drug | C00023770 | 1 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00023770 | 0 / 1 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002762 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00023770 | 1 / 0 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00023770 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00029476 | 0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00023770 | 2 / 0 |
| P51843 | Nuclear receptor subfamily 0 group B member 1 | Nuclear hormone receptor subfamily 0 group B member 1 | C00029476 | 2 / 2 |
| P00734 | Prothrombin | S1A | C00023770 | 4 / 2 |
| P14679 | Tyrosinase | Oxidoreductase | C00023770 | 4 / 2 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00023770 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00023770 | 1 / 1 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00002714 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00023770 | 1 / 1 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00002762 | 4 / 1 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00023770 | 0 / 0 |
| P80365 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | C00023770 | 1 / 1 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00023770 | 1 / 1 |
| O00255 | Menin | Unclassified protein | C00002607 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00002607 | 1 / 2 |
2 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00002762
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00002762
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (28)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300018 | 46,xy sex reversal 2; srxy2 |
P51843
|
| #300200 | Adrenal hypoplasia, congenital; ahc |
P51843
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #218030 | Apparent mineralocorticoid excess; ame |
P80365
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #614390 | Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 |
P00734
|
| #613679 | Prothrombin deficiency, congenital |
P00734
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601367 | Stroke, ischemic |
P00734
|
| #188050 | Thrombophilia due to thrombin defect; thph1 |
P00734
|
KEGG DISEASE (22)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00223 | Inherited thrombophilia |
P00734
(related)
|
| H01254 | Congenital prothrombin deficiency |
P00734
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00038 | Malignant melanoma |
P14679
(marker)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00552 | Glycerol kinase deficiency (GKD) |
P51843
(related)
|
| H00607 | 46,XY disorders of sex development (Disorders of gonadal development) |
P51843
(related)
|
| H00259 | Apparent mineralocorticoid excess syndrome |
P80365
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|