Dorstenia psilurus

• Index
• Plant Species
• Metabolite list (18)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Dorstenia psilurus
Genus	Dorstenia
Family	Moraceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Dorstenia psilurus
Linked NCBI taxonomy ID	106723
Linked level	species

Family

Family in NCBI taxonomy	Moraceae
ID	3487

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	rosids
ID	71275

Metabolite list (18)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00039041	Dorsilurin F	CHEMBL489270				No. 14	No. 15
C00039042	Dorsilurin G / (-)-Dorsilurin G	CHEMBL489067				No. 14	No. 15
C00013417	Dorsilurin A / 2-[2,4-Dihydroxy-3-(3-methyl-2-butenyl)phenyl]-5,7-dihydroxy-6,8-bis(3-methyl-2-butenyl)-4H-1-benzopyran-4-one					No. 14	No. 15
C00013416	Dorsilurin D / (+)-2-(2,4-Dihydroxyphenyl)-5,7-dihydroxy-8-(2-hydroxy-3-methyl-3-butenyl)-3,6-bis(3-methyl-2-butenyl)-4H-1-benzopyran-4-one					No. 14	No. 15
C00039043	Dorsilurin H / (-)-Dorsilurin H	CHEMBL489068				No. 44
C00039044	Dorsilurin I / (-)-Dorsilurin I	CHEMBL489470				No. 44
C00039045	Dorsilurin J	CHEMBL455685				No. 44
C00039046	Dorsilurin K	CHEMBL455686				No. 44
C00013458	Dorsilurin B / (-)-2-(2,4-Dihydroxyphenyl)-9,10-dihydro-5,9-dihydroxy-8,8-dimethyl-3,6-bis(3-methyl-2-butenyl)-4H,8H-benzo[1,2-b:3,4-b']dipyran-4-one					No. 44
C00013537	Dorsilurin C / 2-(2,2-Dimethyl-2H-1-benzopyran-7-yl)-3,5,7-trihydroxy-6,8-bis(3-methyl-2-butenyl)-4H-1-benzopyran-4-one	CHEMBL455687				No. 44
C00044328	Stearyl ferulate					No. 447
C00001835	Cephaeline	CHEMBL255708 CHEMBL486005 CHEMBL1616444	C005963	3 / 0 / 0	6 / 0	No. 510	No. 4
C00000583	Isopimpinellin	CHEMBL140796	C015304	9 / 3 / 4	2 / 0	No. 606	No. 25
C00002493	Pimpinellin	CHEMBL1491809	C039409	3 / 0 / 1		No. 606	No. 25
C00037321	Isobergapten	CHEMBL141690		8 / 5 / 4		No. 1282	No. 25
C00000297	Psoralen	CHEMBL164660	D005363	12 / 6 / 6	0 / 5	No. 1282	No. 25
C00000575	Bergaptan	CHEMBL24171	C022909	22 / 22 / 17	0 / 3	No. 1282	No. 25
C00013430	Dorsilurin E / 2,(6Z)-6-(3,4,7,8,12,13-Hexahydro-2,2,6,6,13,13-hexamethyl-2H,6H,10H,11H-tripyrano[3,2-c:2',3'-f:2'',3''-h][1]benzopyran-10-ylidene)-3-hydroxy-4-cyclohexadien-1-one					No. 5824

Human Protein / Gene in interactions

38 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00000297 C00000575 C00000583 C00002493 C00037321	0 / 1
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00000297 C00000575 C00000583 C00037321	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00000575 C00002493 C00037321	0 / 0
P56817	Beta-secretase 1	A1A	C00000297 C00000575 C00000583	0 / 0
P20813	Cytochrome P450 2B6	Cytochrome P450 2B6	C00000297 C00000575	1 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00000297 C00000575	1 / 1
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00000297 C00000575	3 / 3
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00000575 C00000583	0 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00000297 C00000575	1 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00000297 C00000575	0 / 1
P11509	Cytochrome P450 2A6	Cytochrome P450 2A6	C00000297 C00000575	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00000297 C00000575	0 / 0
P16389	Potassium voltage-gated channel subfamily A member 2	KCNA, Kv1.x (Shaker)	C00000575	0 / 0
P20701	Integrin alpha-L	Membrane receptor	C00001835	0 / 0
P11388	DNA topoisomerase 2-alpha	Isomerase	C00000297	0 / 0
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00001835	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00000583	0 / 0
O75496	Geminin	Unclassified protein	C00037321	0 / 0
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00000575	7 / 3
P08183	Multidrug resistance protein 1	drug	C00000575	1 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00037321	0 / 0
P16473	Thyrotropin receptor	Glycohormone receptor	C00000575	3 / 2
P17658	Potassium voltage-gated channel subfamily A member 6	K	C00000575	0 / 0
P27540	Aryl hydrocarbon receptor nuclear translocator	Unclassified protein	C00001835	0 / 0
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00000583	2 / 2
P19838	Nuclear factor NF-kappa-B p105 subunit	Transcription Factor	C00000297	0 / 0
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00002493	0 / 0
P22001	Potassium voltage-gated channel subfamily A member 3	KCNA, Kv1.x (Shaker)	C00000575	0 / 0
P06746	DNA polymerase beta	Enzyme	C00000583	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00000583	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00037321	4 / 3
P48547	Potassium voltage-gated channel subfamily C member 1	K	C00000575	0 / 0
P10275	Androgen receptor	NR3C4	C00000575	3 / 4
P22460	Potassium voltage-gated channel subfamily A member 5	KCNA, Kv1.x (Shaker)	C00000575	1 / 1
Q09470	Potassium voltage-gated channel subfamily A member 1	KCNA, Kv1.x (Shaker)	C00000575	1 / 1
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00037321	0 / 0
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00037321	1 / 0
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00000583	1 / 1

8 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
6347	CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF	chemokine (C-C motif) ligand 2	C00001835
6351	CCL4, ACT2, AT744.1, G-26, HC21, LAG-1, LAG1, MIP-1-beta, MIP1B, MIP1B1, SCYA2, SCYA4	chemokine (C-C motif) ligand 4	C00001835
6352	CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP	chemokine (C-C motif) ligand 5	C00001835
3570	IL6R, CD126, IL-6R-1, IL-6RA, IL6Q, IL6RA, IL6RQ, gp80	interleukin 6 receptor	C00001835
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00001835
7422	VEGFA, MVCD1, VEGF, VPF	vascular endothelial growth factor A	C00001835
1545	CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	C00000583
8856	NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR	nuclear receptor subfamily 1, group I, member 2	C00000583

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions