| Organism name | Euphorbia spp. |
|---|---|
| Genus | Euphorbia |
| Family | Euphorbiaceae |
| Kingdom | Plantae |
| Linked NCBI taxonomy name | Euphorbiaceae |
|---|---|
| Linked NCBI taxonomy ID | 3977 |
| Linked level | family |
| Family in NCBI taxonomy | Euphorbiaceae |
|---|---|
| ID | 3977 |
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
| Plant class | rosids |
|---|---|
| ID | 71275 |
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
|
C00005141
|
Kaempferol 3-glucuronide
/ Kaempferol-3-O-beta-D-glucuronide |
No. 2 | No. 15 |
|
||||
|
C00005376
|
Miquelianin
/ Quercetin 3-O-beta-D-glucuronide |
CHEMBL520546
CHEMBL1506682 |
23 / 30 / 21 | No. 2 | No. 15 |
|
||
|
C00008698
|
Taxifolin 3-galactoside
|
CHEMBL2332678
CHEMBL2332679 |
No. 12 | No. 14 |
|
|||
|
C00006039
|
Myricetin 3-(6''-galloylgalactoside)
|
No. 98 |
|
|||||
|
C00003745
|
Euphol
/ alpha-Euphol / (+)-alpha-Euphol |
CHEMBL225111
CHEMBL465181 CHEMBL1397369 |
C062557
|
10 / 17 / 17 | No. 218 | No. 51 |
|
|
|
C00002931
|
Mallotusinic acid
|
No. 226 | No. 81 |
|
||||
|
C00002926
|
Geraniin
|
CHEMBL506069
|
C024603
|
1 / 4 / 2 | 0 / 1 | No. 226 | No. 81 |
|
|
C00003439
|
Ingenol
|
CHEMBL346507
CHEMBL2165402 |
C008125
|
1 / 0 / 0 | No. 3700 | No. 41 |
|
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P02545 | Prelamin-A/C | Unclassified protein | C00003745 C00005376 | 11 / 10 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00003745 C00005376 | 4 / 3 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00003745 C00005376 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00005376 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00005376 | 0 / 0 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00003745 | 0 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00005376 | 0 / 0 |
| Q16850 | Lanosterol 14-alpha demethylase | Cytochrome P450 51A1 | C00003745 | 0 / 0 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00005376 | 1 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00003745 | 2 / 3 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00005376 | 1 / 1 |
| P39748 | Flap endonuclease 1 | Enzyme | C00005376 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00005376 | 7 / 3 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00005376 | 1 / 1 |
| P09923 | Intestinal-type alkaline phosphatase | Enzyme | C00005376 | 0 / 0 |
| P05186 | Alkaline phosphatase, tissue-nonspecific isozyme | Enzyme | C00005376 | 3 / 1 |
| P17252 | Protein kinase C alpha type | Alpha | C00003439 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00003745 | 0 / 0 |
| P10696 | Alkaline phosphatase, placental-like | Enzyme | C00005376 | 0 / 1 |
| P12821 | Angiotensin-converting enzyme | M2 | C00002926 | 4 / 2 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00003745 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00003745 | 0 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00005376 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00005376 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00005376 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00005376 | 0 / 0 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00003745 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00005376 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00005376 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00005376 | 0 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00005376 | 0 / 0 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00005376 | 2 / 1 |
| OMIM | preferred title | UniProt |
|---|---|---|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
Q14191
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #614519 | Hemorrhage, intracerebral, susceptibility to; ich |
P12821
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #146300 | Hypophosphatasia, adult |
P05186
|
| #241510 | Hypophosphatasia, childhood |
P05186
|
| #241500 | Hypophosphatasia, infantile |
P05186
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #612624 | Microvascular complications of diabetes, susceptibility to, 3; mvcd3 |
P12821
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #267430 | Renal tubular dysgenesis; rtd |
P12821
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #601367 | Stroke, ischemic |
P12821
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #277700 | Werner syndrome; wrn |
Q14191
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
| KEGG | name | UniProt |
|---|---|---|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00213 | Hypophosphatasia |
P05186
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00023 | Testicular cancer |
P10696
(marker)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00083 | Allograft rejection |
P12821
(related)
|
| H00575 | Renal tubular dysgenesis |
P12821
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00296 | Defects in RecQ helicases |
Q14191
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|