Species

KNApSAcK Entry

Organism name Cratoxylum cochinchinense
Genus Cratoxylum
Family Hypericaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Cratoxylum cochinchinense
Linked NCBI taxonomy ID 271749
Linked level species

Family

Family in NCBI taxonomy Hypericaceae
ID 629714

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (11)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00002963 External link 512 Mangostin
/ alpha-Mangostin
CHEMBL323197
C021053
25 / 27 / 58 0 / 3 No. 14 No. 15
C00029359 External link 512 1,3,7-Trihydroxy-2,4-di(3-methylbut-2-enyl)xanthone
CHEMBL1782240
1 / 0 / 0 No. 14 No. 15
C00029819 External link 512 beta-Mangostin
CHEMBL261706
3 / 0 / 0 No. 14 No. 15
C00029995 External link 512 Cochinchinone A
CHEMBL1782241
1 / 0 / 0 No. 14 No. 15
C00029569 External link 512 5-O-Methylcelebixanthone
No. 15 No. 15
C00029920 External link 512 Celebixanthone
No. 15 No. 15
C00029379 External link 512 11-Hydroxy-1-isomangostin
CHEMBL1080697
2 / 0 / 0 No. 47 No. 15
C00035281 External link 512 Cratoxylone
No. 47 No. 15
C00036594 External link 512 5'-Demethoxycadensin G
No. 338
C00040749 External link 512 (13E,17E)-Polypoda-7,13,17,21-tetraen-3beta-ol
/ (+)-(13E,17E)-Polypoda-7,13,17,21-tetraen-3beta-ol
No. 801 No. 50
C00029996 External link 512 Cochinchinone C
No. 2057

Human Protein / Gene in interactions

25 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q04206 Transcription factor p65 Transcription Factor C00002963 C00029359 C00029379 C00029819 C00029995 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00002963 C00029379 C00029819 0 / 0
P49327 Fatty acid synthase Transferase C00002963 C00029819 0 / 0
Q00987 E3 ubiquitin-protein ligase Mdm2 Other nuclear protein C00002963 1 / 5
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00002963 0 / 1
P00352 Retinal dehydrogenase 1 Enzyme C00002963 0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme C00002963 2 / 2
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00002963 0 / 0
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00002963 2 / 2
O60906 Sphingomyelin phosphodiesterase 2 Enzyme C00002963 0 / 0
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme C00002963 2 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00002963 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002963 1 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00002963 3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00002963 2 / 2
O14763 Tumor necrosis factor receptor superfamily member 10B Unclassified protein C00002963 1 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00002963 7 / 37
P16050 Arachidonate 15-lipoxygenase Enzyme C00002963 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00002963 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002963 0 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00002963 4 / 3
Q9UBT6 DNA polymerase kappa Enzyme C00002963 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002963 0 / 0
O00255 Menin Unclassified protein C00002963 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002963 1 / 2

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (27)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#614401 Accelerated tumor formation, susceptibility to; actfs Q00987
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#114500 Colorectal cancer; crc P18054
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#133239 Esophageal cancer P04637
P18054
#600274 Frontotemporal dementia; ftd P10636
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#211980 Lung cancer P04637
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#275355 Squamous cell carcinoma, head and neck; hnscc O14763
P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (58)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
Q00987 (related)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
Q00987 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
Q00987 (related)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
Q00987 (related)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P11511 (related)
H00794 Aromatase excess syndrome P11511 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00037 Alveolar rhabdomyosarcoma Q00987 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

3 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D058186 Acute Kidney Injury C00002963
D009202 Cardiomyopathies C00002963
D009203 Myocardial Infarction C00002963