Species

KNApSAcK Entry

Organism name Capillipedium parviflorum
Genus Capillipedium
Family Poaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Capillipedium parviflorum
Linked NCBI taxonomy ID 79829
Linked level species

Family

Family in NCBI taxonomy Poaceae
ID 4479

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Liliopsida
ID 4447

Metabolite list (29)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00035451 External link 512 1,10-Diepi-cubenol
No. 205 No. 38
C00020065 External link 512 alpha-Cadinol
/ (-)-alpha-Cadinol
CHEMBL486795
No. 205 No. 38
C00020130 External link 512 gamma-Muurolene
/ 1beta-Cadina-4,10(15)-diene
No. 283 No. 39
C00000816 External link 512 beta-Pinene
CHEMBL501351
C010789
No. 476 No. 35
C00000805 External link 512 alpha-Pinene
CHEMBL442565
C005451
3 / 3 / 2 0 / 1 No. 476 No. 35
C00003110 External link 512 Caryophyllene
/ (E)-Caryophyllene
/ beta-Caryophyllene
/ (-)-(E)-Caryophyllene
/ (E)-beta-Caryophyllene
CHEMBL445740
CHEMBL448700
2 / 3 / 7 No. 478 No. 38
C00012483 External link 512 Betula pubescens
/ Caryophyllene oxide
/ trans-Caryophyllene oxide
/ beta-Caryophyllene epoxide
/ (-)-Epoxydihydrocaryophyllene
/ 6,7-Epoxy-3(15)-caryophyllene
/ (-)-beta-Caryophyllene epoxide
/ 4beta,5alpha-Epoxycaryophyllene
/ Caryophyllene 4beta,5alpha-epoxide
CHEMBL399036
CHEMBL508894
CHEMBL479134
CHEMBL1513806
CHEMBL1553274
3 / 1 / 3 No. 500
C00003047 External link 512 Linalool
/ (R)-linalool
/ (R)-(-)-3,7-Dimethyl-1,6-octadien-3-ol
CHEMBL25306
CHEMBL235672
C018584
6 / 8 / 2 35 / 4 No. 958 No. 34
C00003147 External link 512 Humulene
/ alpha-Caryophyllene
/ (+/-)-alpha-Humulene
CHEMBL251280
C042686
No. 1421 No. 38
C00029545 External link 512 4-Tridecanone
CHEMBL1922860
No. 1611
C00035459 External link 512 11-Methyl-4-dodecanone
No. 1611
C00035507 External link 512 4-Undecanone
No. 1611
C00035501 External link 512 4-Heptanone
C038029
No. 1738
C00035504 External link 512 4-Nonanone
No. 1738
C00035479 External link 512 2-Hexen-1-ol
No. 1746
C00035700 External link 512 n-Heptanol
CHEMBL273459
D019850
1 / 0 No. 1749
C00001264 External link 512 Octanol
/ n-Octanol
/ 1-Octanol
/ Octan-1-ol
CHEMBL26215
D020003
5 / 6 / 5 2 / 0 No. 1749
C00030099 External link 512 Decanal
/ Capraldehyde
C021170
2 / 0 No. 1993
C00030828 External link 512 Nonanal
/ n-Nonanal
C008664
1 / 1 No. 1993
C00035499 External link 512 4-Decanol
No. 2473
C00035506 External link 512 4-Undecanol
No. 2473
C00035503 External link 512 4-Nonanol
No. 2473
C00011720 External link 512 Germacrene D
/ (-)-Germacrene D
CHEMBL105432
CHEMBL1836650
No. 2639 No. 38
C00035495 External link 512 3-Octanol
CHEMBL487998
No. 2707
C00035500 External link 512 4-Heptanol
No. 2707
C00035480 External link 512 2-Hexenal
C051750
8 / 3 No. 2883
C00000357 External link 512 Hexanal
CHEMBL280331
C010463
7 / 0 No. 3593
C00035766 External link 512 trans-2-Hexenyl acetate
No. 4548
C00035767 External link 512 trans-2-Hexenyl butyrate
No. 4568

Human Protein / Gene in interactions

17 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10828 Thyroid hormone receptor beta NR1A2 C00001264 C00003047 3 / 1
P83916 Chromobox protein homolog 1 Unclassified protein C00001264 C00003047 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001264 3 / 3
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00012483 0 / 1
P00352 Retinal dehydrogenase 1 Enzyme C00001264 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00000805 3 / 2
P04150 Glucocorticoid receptor NR3C1 C00001264 0 / 1
P28482 Mitogen-activated protein kinase 1 Erk C00000805 0 / 0
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00003047 3 / 0
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00000805 0 / 0
Q9Y4X1 UDP-glucuronosyltransferase 2A1 Enzyme C00003047 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00003047 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00012483 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00012483 0 / 1
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00003047 5 / 1
O00255 Menin Unclassified protein C00003110 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00003110 1 / 2

46 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
231 AKR1B1, ADR, ALDR1, ALR2, AR aldo-keto reductase family 1, member B1 (aldose reductase) (EC:1.1.1.21) C00000357 C00030099 C00030828 C00035480
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00003047 C00035480
218 ALDH3A1, ALDH3, ALDHIII aldehyde dehydrogenase 3 family, member A1 (EC:1.2.1.5) C00000357 C00035480
1080 CFTR, ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1 cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) C00001264 C00035700
217 ALDH2, ALDH-E2, ALDHI, ALDM aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) C00000357 C00030099
4609 MYC, MRTL, MYCC, bHLHe39, c-Myc v-myc avian myelocytomatosis viral oncogene homolog C00000357 C00003047
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00000357 C00003047
1646 AKR1C2, AKR1C-pseudo, BABP, DD, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8 aldo-keto reductase family 1, member C2 (EC:1.3.1.20 1.1.1.357) C00003047 C00035480
2729 GCLC, GCL, GCS, GLCL, GLCLC glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) C00003047
1386 ATF2, CRE-BP1, CREB2, HB16, TREB7 activating transcription factor 2 (EC:2.3.1.48) C00003047
329 BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1 baculoviral IAP repeat containing 2 C00003047
330 BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2 baculoviral IAP repeat containing 3 C00003047
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00003047
1027 CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 cyclin-dependent kinase inhibitor 1B (p27, Kip1) C00003047
1028 CDKN1C, BWCR, BWS, KIP2, WBS, p57, p57Kip2 cyclin-dependent kinase inhibitor 1C (p57, Kip2) C00003047
1030 CDKN2B, CDK4I, INK4B, MTS2, P15, TP15, p15INK4b cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) C00003047
1447 CSN2, CASB casein beta C00003047
1509 CTSD, CLN10, CPSD cathepsin D (EC:3.4.23.5) C00003047
501 ALDH7A1, ATQ1, EPD, PDE aldehyde dehydrogenase 7 family, member A1 (EC:1.2.1.3 1.2.1.8 1.2.1.31) C00000357
1906 EDN1, ET1, HDLCQ7, PPET1 endothelin 1 C00003047
1956 EGFR, ERBB, ERBB1, HER1, PIG61, mENA epidermal growth factor receptor (EC:2.7.10.1) C00003047
2335 FN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF fibronectin 1 C00003047
1647 GADD45A, DDIT1, GADD45 growth arrest and DNA-damage-inducible, alpha C00003047
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00003047
3156 HMGCR, LDLCQ3 3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) C00003047
3297 HSF1, HSTF1 heat shock transcription factor 1 C00003047
3320 HSP90AA1, EL52, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP2 heat shock protein 90kDa alpha (cytosolic), class A member 1 C00003047
3308 HSPA4, APG-2, HS24/P52, HSPH2, RY, hsp70, hsp70RY heat shock 70kDa protein 4 C00003047
3316 HSPB2, HSP27, Hs.78846, LOH11CR1K, MKBP heat shock 27kDa protein 2 C00003047
3398 ID2, GIG8, ID2A, ID2H, bHLHb26 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein C00003047
3638 INSIG1, CL-6, CL6 insulin induced gene 1 C00003047
3725 JUN, AP-1, AP1, c-Jun jun proto-oncogene C00003047
8850 KAT2B, CAF, P, P/CAF, PCAF K(lysine) acetyltransferase 2B (EC:2.3.1.48) C00003047
4193 MDM2, ACTFS, HDMX, hdm2 MDM2 oncogene, E3 ubiquitin protein ligase C00003047
4790 NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 C00003047
4852 NPY, PYY4 neuropeptide Y C00003047
100124292 C00003047
7295 TXN, TRDX, TRX, TRX1 thioredoxin C00003047
7471 WNT1, BMND16, INT1, OI15 wingless-type MMTV integration site family, member 1 C00003047
26118 WSB1, SWIP1, WSB-1 WD repeat and SOCS box containing 1 C00003047
57016 AKR1B10, AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HSI aldo-keto reductase family 1, member B10 (aldose reductase) (EC:1.1.1.2) C00035480
2950 GSTP1, DFN7, FAEES3, GST3, GSTP, PI glutathione S-transferase pi 1 (EC:2.5.1.18) C00035480
3162 HMOX1, HMOX1D, HO-1, HSP32, bK286B10 heme oxygenase (decycling) 1 (EC:1.14.99.3) C00035480
23764 MAFF, U-MAF, hMafF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F C00035480
221 ALDH3B1, ALDH4, ALDH7 aldehyde dehydrogenase 3 family, member B1 (EC:1.2.1.5) C00000357
128 ADH5, ADH-3, ADHX, FALDH, FDH, GSH-FDH, GSNOR alcohol dehydrogenase 5 (class III), chi polypeptide (EC:1.1.1.1 1.1.1.284) C00001264

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (18)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#609535 Drug metabolism, poor, cyp2c19-related P33261
#143500 Gilbert syndrome P22309
P22310
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828

KEGG DISEASE (18)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00036 Osteosarcoma P08684 (marker)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H01205 Coumarin resistance P11712 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00208 Hyperbilirubinemia P22309 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

8 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D009369 Neoplasms C00003047
C00035480
D007938 Leukemia C00003047
D017453 Dermatitis, Irritant C00003047
D006937 Hypercholesterolemia C00003047
D009336 Necrosis C00030828
D003877 Dermatitis, Contact C00000805
D001008 Anxiety Disorders C00035480
D003110 Colonic Neoplasms C00035480