KNApSAcK Entry

Organism name Piper methysticum
Genus Piper
Family Piperaceae
Kingdom Plantae

NCBI taxonomy


Linked NCBI taxonomy name Piper methysticum
Linked NCBI taxonomy ID 130404
Linked level species


Family in NCBI taxonomy Piperaceae
ID 16739

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Magnoliophyta
ID 3398

Natural Activity

List (43)

Species Activity
Piper methysticum G. Forster Allergenic
Piper methysticum G. Forster Analgesic
Piper methysticum G. Forster Anaphrodisiac
Piper methysticum G. Forster Anesthetic
Piper methysticum G. Forster Antiaggregant
Piper methysticum G. Forster Antibacterial
Piper methysticum G. Forster Anticonvulsant
Piper methysticum G. Forster Antidepressant
Piper methysticum G. Forster Antidopamine
Piper methysticum G. Forster Antiepileptic
Piper methysticum G. Forster Antifatigue
Piper methysticum G. Forster Antiischemic
Piper methysticum G. Forster Antipyretic
Piper methysticum G. Forster Antirheumatic
Piper methysticum G. Forster Antiseptic
Piper methysticum G. Forster Antispasmodic
Piper methysticum G. Forster Antithrombic
Piper methysticum G. Forster Anxiolytic
Piper methysticum G. Forster Aperitif
Piper methysticum G. Forster Aphrodisiac
Piper methysticum G. Forster Climacteric
Piper methysticum G. Forster CNS-Depressant
Piper methysticum G. Forster Contraceptive
Piper methysticum G. Forster Cyclooxygenase Inhibitor
Piper methysticum G. Forster Diaphoretic
Piper methysticum G. Forster Diuretic
Piper methysticum G. Forster Dopaminergic
Piper methysticum G. Forster Expectorant
Piper methysticum G. Forster Fungicide
Piper methysticum G. Forster Hypnotic
Piper methysticum G. Forster Hyporeflexic
Piper methysticum G. Forster Lactagogue
Piper methysticum G. Forster Memorigenic
Piper methysticum G. Forster Myorelaxant
Piper methysticum G. Forster Narcotic
Piper methysticum G. Forster Neuroprotective
Piper methysticum G. Forster Psychotropic
Piper methysticum G. Forster Sedative
Piper methysticum G. Forster Serotoninergic
Piper methysticum G. Forster Sobering
Piper methysticum G. Forster Stimulant
Piper methysticum G. Forster Tonic
Piper methysticum G. Forster Tranquilizer

Metabolite list (20)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
C00006936 External link 512 Flavokawin B
19 / 31 / 55 No. 79
C00006957 External link 512 Flavokawain C
No. 79
C00006958 External link 512 Flavokawin A
/ 2'-Hydroxy-4,4',6'-trimethoxychalcone
3 / 3 / 0 No. 79
C00014601 External link 512 Flavokawin A
/ Flavokavain A
No. 90 No. 13
C00030253 External link 512 Flavokavain C
No. 90 No. 13
C00025787 External link 512 Cepharadione A
No. 125
C00002987 External link 512 5,6-Dehydrokawain
12 / 16 / 44 No. 1312 No. 63
C00029551 External link 512 5,6-Dehydromethysticin
No. 1312 No. 63
C00029373 External link 512 10-Methoxyyagonin
No. 1312 No. 63
C00003024 External link 512 Yangonin
16 / 25 / 49 No. 1312 No. 63
C00003005 External link 512 Methysticin
10 / 14 / 40 No. 2531 No. 63
C00002988 External link 512 Dihydromethysticin
11 / 2 / 3 No. 2531 No. 63
C00029378 External link 512 11-Hydroxy-12-methoxydihydrokavain
No. 2531 No. 63
C00029583 External link 512 Marindinin
/ 7,8-Dihydrokavain
5 / 3 / 5 No. 2531 No. 63
C00030497 External link 512 Hydroxykavain
No. 3123 No. 63
C00003000 External link 512 Kawain
18 / 11 / 7 No. 3123 No. 63
C00029962 External link 512 Cinnamic acid bornyl ester
No. 3870
C00037653 External link 512 Pipermethystine
No. 4827
C00024779 External link 512 Yagonin
/ Yagonine
No. 5337
C00036788 External link 512 Awaine
No. 6832

Human Protein / Gene in interactions

48 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
P19793 Retinoic acid receptor RXR-alpha NR2B1 C00002987 C00002988 C00003000 C00003005 C00003024 C00029583 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002987 C00002988 C00003000 C00003005 C00006936 C00029583 0 / 1
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00002987 C00002988 C00003000 C00003005 C00003024 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00002987 C00002988 C00003000 C00003005 C00003024 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00002987 C00002988 C00003000 C00003005 C00003024 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00002987 C00003000 C00003005 C00003024 4 / 1
P04637 Cellular tumor antigen p53 Transcription Factor C00002987 C00003005 C00003024 C00006936 7 / 37
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00002987 C00002988 C00003000 C00029583 0 / 0
Q96RI1 Bile acid receptor NR1H4 C00002987 C00002988 C00003005 C00003024 0 / 0
O75496 Geminin Unclassified protein C00002988 C00003000 C00006936 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00003000 C00003024 C00006936 4 / 3
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00003000 C00006936 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00002987 C00003024 2 / 2
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00006936 C00006958 2 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00003000 C00006936 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00003024 C00006936 3 / 3
P10275 Androgen receptor NR3C4 C00002987 C00029583 3 / 4
P35869 Aryl hydrocarbon receptor Transcription Factor C00002987 C00003024 0 / 0
P10145 Interleukin-8 Secreted protein C00003024 C00029583 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00003024 0 / 1
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00006936 7 / 3
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00006936 1 / 2
P11021 78 kDa glucose-regulated protein Unclassified protein C00006936 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00006936 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00006936 0 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00003024 5 / 3
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00006936 2 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00003000 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00003000 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00006936 2 / 3
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00003000 0 / 1
P08183 Multidrug resistance protein 1 drug C00006958 1 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00003005 3 / 2
P03372 Estrogen receptor NR3A1 C00002988 1 / 1
P55210 Caspase-7 C14 C00003024 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00003000 1 / 1
Q13315 Serine-protein kinase ATM Atypical serine/threonine protein kinase PIKK subfamily C00006936 1 / 4
Q9UNA4 DNA polymerase iota Enzyme C00002988 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00006936 0 / 0
P29466 Caspase-1 C14 C00003024 0 / 0
Q99700 Ataxin-2 Unclassified protein C00006936 1 / 1
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00003000 1 / 0
P33527 Multidrug resistance-associated protein 1 drugs C00006958 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00003005 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00003000 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00002988 1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00006936 1 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00003000 1 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (53)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#208900 Ataxia-telangiectasia; at Q13315
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#614490 Blood group, junior system; jr Q9UNQ0
%606641 Body mass index; bmi P37231
#609338 Carotid intimal medial thickness 1 P37231
#114500 Colorectal cancer; crc P84022
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#211980 Lung cancer P04637
#174800 Mccune-albright syndrome; mas P63092
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#601665 Obesity P37231
#166350 Osseous heteroplasia, progressive; poh P63092
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473


KEGG name UniProt
H00026 Endometrial Cancer P03372 (marker)
P04637 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
Q13315 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
P37231 (related)
H00033 Adrenal carcinoma P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00064 Ataxia telangiectasia (AT) Q13315 (related)
H00094 DNA repair defects Q13315 (related)
H00848 Ataxia with ocular apraxia (AOA) Q13315 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)