Piper methysticum
Species
KNApSAcK Entry
| Organism name | Piper methysticum |
|---|---|
| Genus | Piper |
| Family | Piperaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Piper methysticum |
|---|---|
| Linked NCBI taxonomy ID | 130404 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Piperaceae |
|---|---|
| ID | 16739 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | Magnoliophyta |
|---|---|
| ID | 3398 |
Natural Activity
List (43)
| Species | Activity |
|---|---|
| Piper methysticum G. Forster | Allergenic |
| Piper methysticum G. Forster | Analgesic |
| Piper methysticum G. Forster | Anaphrodisiac |
| Piper methysticum G. Forster | Anesthetic |
| Piper methysticum G. Forster | Antiaggregant |
| Piper methysticum G. Forster | Antibacterial |
| Piper methysticum G. Forster | Anticonvulsant |
| Piper methysticum G. Forster | Antidepressant |
| Piper methysticum G. Forster | Antidopamine |
| Piper methysticum G. Forster | Antiepileptic |
| Piper methysticum G. Forster | Antifatigue |
| Piper methysticum G. Forster | Antiischemic |
| Piper methysticum G. Forster | Antipyretic |
| Piper methysticum G. Forster | Antirheumatic |
| Piper methysticum G. Forster | Antiseptic |
| Piper methysticum G. Forster | Antispasmodic |
| Piper methysticum G. Forster | Antithrombic |
| Piper methysticum G. Forster | Anxiolytic |
| Piper methysticum G. Forster | Aperitif |
| Piper methysticum G. Forster | Aphrodisiac |
| Piper methysticum G. Forster | Climacteric |
| Piper methysticum G. Forster | CNS-Depressant |
| Piper methysticum G. Forster | Contraceptive |
| Piper methysticum G. Forster | Cyclooxygenase Inhibitor |
| Piper methysticum G. Forster | Diaphoretic |
| Piper methysticum G. Forster | Diuretic |
| Piper methysticum G. Forster | Dopaminergic |
| Piper methysticum G. Forster | Expectorant |
| Piper methysticum G. Forster | Fungicide |
| Piper methysticum G. Forster | Hypnotic |
| Piper methysticum G. Forster | Hyporeflexic |
| Piper methysticum G. Forster | Lactagogue |
| Piper methysticum G. Forster | Memorigenic |
| Piper methysticum G. Forster | Myorelaxant |
| Piper methysticum G. Forster | Narcotic |
| Piper methysticum G. Forster | Neuroprotective |
| Piper methysticum G. Forster | Psychotropic |
| Piper methysticum G. Forster | Sedative |
| Piper methysticum G. Forster | Serotoninergic |
| Piper methysticum G. Forster | Sobering |
| Piper methysticum G. Forster | Stimulant |
| Piper methysticum G. Forster | Tonic |
| Piper methysticum G. Forster | Tranquilizer |
Metabolite list (20)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00006936
|
Flavokawin B
|
CHEMBL104255
|
19 / 31 / 55 | No. 79 |
|
|||
|
C00006957
|
Flavokawain C
|
CHEMBL251958
|
No. 79 |
|
||||
|
C00006958
|
Flavokawin A
/ 2'-Hydroxy-4,4',6'-trimethoxychalcone |
CHEMBL243829
|
3 / 3 / 0 | No. 79 |
|
|||
|
C00014601
|
Flavokawin A
/ Flavokavain A |
CHEMBL523190
|
No. 90 | No. 13 |
|
|||
|
C00030253
|
Flavokavain C
|
CHEMBL481649
|
No. 90 | No. 13 |
|
|||
|
C00025787
|
Cepharadione A
|
CHEMBL235921
|
No. 125 |
|
||||
|
C00002987
|
5,6-Dehydrokawain
|
CHEMBL254218
|
C052297
|
12 / 16 / 44 | No. 1312 | No. 63 |
|
|
|
C00029551
|
5,6-Dehydromethysticin
|
CHEMBL1946690
|
No. 1312 | No. 63 |
|
|||
|
C00029373
|
10-Methoxyyagonin
|
No. 1312 | No. 63 |
|
||||
|
C00003024
|
Yangonin
|
CHEMBL1098658
|
C110481
|
16 / 25 / 49 | No. 1312 | No. 63 |
|
|
|
C00003005
|
Methysticin
|
CHEMBL579224
CHEMBL1883024 |
C076881
|
10 / 14 / 40 | No. 2531 | No. 63 |
|
|
|
C00002988
|
Dihydromethysticin
|
CHEMBL576066
CHEMBL1510786 |
11 / 2 / 3 | No. 2531 | No. 63 |
|
||
|
C00029378
|
11-Hydroxy-12-methoxydihydrokavain
|
No. 2531 | No. 63 |
|
||||
|
C00029583
|
Marindinin
/ 7,8-Dihydrokavain |
CHEMBL569329
CHEMBL1338909 |
C113859
|
5 / 3 / 5 | No. 2531 | No. 63 |
|
|
|
C00030497
|
Hydroxykavain
|
No. 3123 | No. 63 |
|
||||
|
C00003000
|
Kawain
|
CHEMBL578607
CHEMBL1473874 CHEMBL1482039 |
18 / 11 / 7 | No. 3123 | No. 63 |
|
||
|
C00029962
|
Cinnamic acid bornyl ester
|
No. 3870 |
|
|||||
|
C00037653
|
Pipermethystine
|
C448623
|
No. 4827 |
|
||||
|
C00024779
|
Yagonin
/ Yagonine |
No. 5337 |
|
|||||
|
C00036788
|
Awaine
|
No. 6832 |
|
Human Protein / Gene in interactions
48 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | C00002987 C00002988 C00003000 C00003005 C00003024 C00029583 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002987 C00002988 C00003000 C00003005 C00006936 C00029583 | 0 / 1 |
| P51449 | Nuclear receptor ROR-gamma | Nuclear hormone receptor subfamily 1 group F member 3 | C00002987 C00002988 C00003000 C00003005 C00003024 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002987 C00002988 C00003000 C00003005 C00003024 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00002987 C00002988 C00003000 C00003005 C00003024 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00002987 C00003000 C00003005 C00003024 | 4 / 1 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00002987 C00003005 C00003024 C00006936 | 7 / 37 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00002987 C00002988 C00003000 C00029583 | 0 / 0 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00002987 C00002988 C00003005 C00003024 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00002988 C00003000 C00006936 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00003000 C00003024 C00006936 | 4 / 3 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00003000 C00006936 | 0 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00002987 C00003024 | 2 / 2 |
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | C00006936 C00006958 | 2 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00003000 C00006936 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00003024 C00006936 | 3 / 3 |
| P10275 | Androgen receptor | NR3C4 | C00002987 C00029583 | 3 / 4 |
| P35869 | Aryl hydrocarbon receptor | Transcription Factor | C00002987 C00003024 | 0 / 0 |
| P10145 | Interleukin-8 | Secreted protein | C00003024 C00029583 | 0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00003024 | 0 / 1 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00006936 | 7 / 3 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00006936 | 1 / 2 |
| P11021 | 78 kDa glucose-regulated protein | Unclassified protein | C00006936 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00006936 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00006936 | 0 / 0 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00003024 | 5 / 3 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00006936 | 2 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00003000 | 0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00003000 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00006936 | 2 / 3 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00003000 | 0 / 1 |
| P08183 | Multidrug resistance protein 1 | drug | C00006958 | 1 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00003005 | 3 / 2 |
| P03372 | Estrogen receptor | NR3A1 | C00002988 | 1 / 1 |
| P55210 | Caspase-7 | C14 | C00003024 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00003000 | 1 / 1 |
| Q13315 | Serine-protein kinase ATM | Atypical serine/threonine protein kinase PIKK subfamily | C00006936 | 1 / 4 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00002988 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00006936 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00003024 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00006936 | 1 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00003000 | 1 / 0 |
| P33527 | Multidrug resistance-associated protein 1 | drugs | C00006958 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00003005 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00003000 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00002988 | 1 / 1 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00006936 | 1 / 0 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00003000 | 1 / 1 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (53)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #208900 | Ataxia-telangiectasia; at |
Q13315
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #614490 | Blood group, junior system; jr |
Q9UNQ0
|
| %606641 | Body mass index; bmi |
P37231
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #133239 | Esophageal cancer |
P04637
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
P37231 |
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #211980 | Lung cancer |
P04637
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #601665 | Obesity |
P37231
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 |
Q9UNQ0
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (69)
| KEGG | name | UniProt |
|---|---|---|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04637 (related) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
Q13315 (related) |
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
P37231 (related) |
| H00033 | Adrenal carcinoma |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
Q13148 (related) |
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P37231
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00064 | Ataxia telangiectasia (AT) |
Q13315
(related)
|
| H00094 | DNA repair defects |
Q13315
(related)
|
| H00848 | Ataxia with ocular apraxia (AOA) |
Q13315
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|