KEGG   PATHWAY: mmu00010
mmu00010                    Pathway                                
Glycolysis / Gluconeogenesis - Mus musculus (house mouse)
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
Metabolism; Carbohydrate metabolism
Pathway map
mmu00010  Glycolysis / Gluconeogenesis

mmu_M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [PATH:mmu00010]
mmu_M00002  Glycolysis, core module involving three-carbon compounds [PATH:mmu00010]
mmu_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:mmu00010]
mmu_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:mmu00010]
Other DBs
GO: 0006096 0006094
Mus musculus (house mouse) [GN:mmu]
15277  Hk2; hexokinase 2 [KO:K00844] [EC:]
212032  Hk3; hexokinase 3 [KO:K00844] [EC:]
15275  Hk1; hexokinase 1 [KO:K00844] [EC:]
216019  Hkdc1; hexokinase domain containing 1 [KO:K00844] [EC:]
103988  Gck; glucokinase [KO:K12407] [EC:]
14751  Gpi1; glucose-6-phosphate isomerase 1 [KO:K01810] [EC:]
18641  Pfkl; phosphofructokinase, liver, B-type [KO:K00850] [EC:]
18642  Pfkm; phosphofructokinase, muscle [KO:K00850] [EC:]
56421  Pfkp; phosphofructokinase, platelet [KO:K00850] [EC:]
14121  Fbp1; fructose bisphosphatase 1 [KO:K03841] [EC:]
14120  Fbp2; fructose bisphosphatase 2 [KO:K03841] [EC:]
11674  Aldoa; aldolase A, fructose-bisphosphate [KO:K01623] [EC:]
230163  Aldob; aldolase B, fructose-bisphosphate [KO:K01623] [EC:]
11676  Aldoc; aldolase C, fructose-bisphosphate [KO:K01623] [EC:]
353204  Aldoart1; aldolase 1 A, retrogene 1 [KO:K01623] [EC:]
79459  Aldoart2; aldolase 1 A, retrogene 2 [KO:K01623] [EC:]
21991  Tpi1; triosephosphate isomerase 1 [KO:K01803] [EC:]
14433  Gapdh; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:]
115487111  Gm29667; predicted gene 29667 [KO:K00134] [EC:]
14447  Gapdhs; glyceraldehyde-3-phosphate dehydrogenase, spermatogenic [KO:K10705] [EC:]
18655  Pgk1; phosphoglycerate kinase 1 [KO:K00927] [EC:]
18663  Pgk2; phosphoglycerate kinase 2 [KO:K00927] [EC:]
18648  Pgam1; phosphoglycerate mutase 1 [KO:K01834] [EC:]
56012  Pgam2; phosphoglycerate mutase 2 [KO:K01834] [EC:]
13806  Eno1; enolase 1, alpha non-neuron [KO:K01689] [EC:]
13807  Eno2; enolase 2, gamma neuronal [KO:K01689] [EC:]
13808  Eno3; enolase 3, beta muscle [KO:K01689] [EC:]
433182  Eno1b; enolase 1B, retrotransposed [KO:K01689] [EC:]
226265  Eno4; enolase 4 [KO:K01689] [EC:]
18746  Pkm; pyruvate kinase, muscle [KO:K00873] [EC:]
18770  Pklr; pyruvate kinase liver and red blood cell [KO:K12406] [EC:]
18597  Pdha1; pyruvate dehydrogenase E1 alpha 1 [KO:K00161] [EC:]
18598  Pdha2; pyruvate dehydrogenase E1 alpha 2 [KO:K00161] [EC:]
68263  Pdhb; pyruvate dehydrogenase (lipoamide) beta [KO:K00162] [EC:]
235339  Dlat; dihydrolipoamide S-acetyltransferase [KO:K00627] [EC:]
13382  Dld; dihydrolipoamide dehydrogenase [KO:K00382] [EC:]
16828  Ldha; lactate dehydrogenase A [KO:K00016] [EC:]
16832  Ldhb; lactate dehydrogenase B [KO:K00016] [EC:]
16833  Ldhc; lactate dehydrogenase C [KO:K00016] [EC:]
106557  Ldhal6b; lactate dehydrogenase A-like 6B [KO:K00016] [EC:]
11522  Adh1; alcohol dehydrogenase 1 (class I) [KO:K13951] [EC:]
11529  Adh7; alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide [KO:K13951] [EC:]
26876  Adh4; alcohol dehydrogenase 4 (class II), pi polypeptide [KO:K13980] [EC:]
11532  Adh5; alcohol dehydrogenase 5 (class III), chi polypeptide [KO:K00121] [EC:]
58810  Akr1a1; aldo-keto reductase family 1, member A1 [KO:K00002] [EC:]
11669  Aldh2; aldehyde dehydrogenase 2, mitochondrial [KO:K00128] [EC:]
11671  Aldh3a2; aldehyde dehydrogenase family 3, subfamily A2 [KO:K00128] [EC:]
72535  Aldh1b1; aldehyde dehydrogenase 1 family, member B1 [KO:K00128] [EC:]
110695  Aldh7a1; aldehyde dehydrogenase family 7, member A1 [KO:K14085] [EC:]
56752  Aldh9a1; aldehyde dehydrogenase 9, subfamily A1 [KO:K00149] [EC:]
11670  Aldh3a1; aldehyde dehydrogenase family 3, subfamily A1 [KO:K00129] [EC:]
67689  Aldh3b1; aldehyde dehydrogenase 3 family, member B1 [KO:K00129] [EC:]
621603  Aldh3b2; aldehyde dehydrogenase 3 family, member B2 [KO:K00129] [EC:]
73458  Aldh3b3; aldehyde dehydrogenase 3 family, member B3 [KO:K00129] [EC:]
68738  Acss1; acyl-CoA synthetase short-chain family member 1 [KO:K01895] [EC:]
60525  Acss2; acyl-CoA synthetase short-chain family member 2 [KO:K01895] [EC:]
319625  Galm; galactose mutarotase [KO:K01785] [EC:]
72157  Pgm1; phosphoglucomutase 1 [KO:K01835] [EC:]
66681  Pgm2; phosphoglucomutase 2 [KO:K15779] [EC:]
14377  G6pc1; glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:]
14378  G6pc2; glucose-6-phosphatase, catalytic, 2 [KO:K01084] [EC:]
68401  G6pc3; glucose 6 phosphatase, catalytic, 3 [KO:K01084] [EC:]
72141  Adpgk; ADP-dependent glucokinase [KO:K08074] [EC:]
12183  Bpgm; 2,3-bisphosphoglycerate mutase [KO:K01837] [EC:]
17330  Minpp1; multiple inositol polyphosphate histidine phosphatase 1 [KO:K03103] [EC:]
18534  Pck1; phosphoenolpyruvate carboxykinase 1, cytosolic [KO:K01596] [EC:]
74551  Pck2; phosphoenolpyruvate carboxykinase 2 (mitochondrial) [KO:K01596] [EC:]
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00033  Acetate
C00036  Oxaloacetate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00084  Acetaldehyde
C00103  D-Glucose 1-phosphate
C00111  Glycerone phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00186  (S)-Lactate
C00197  3-Phospho-D-glycerate
C00221  beta-D-Glucose
C00236  3-Phospho-D-glyceroyl phosphate
C00267  alpha-D-Glucose
C00469  Ethanol
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C01159  2,3-Bisphospho-D-glycerate
C01172  beta-D-Glucose 6-phosphate
C01451  Salicin
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05345  beta-D-Fructose 6-phosphate
C05378  beta-D-Fructose 1,6-bisphosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Nishizuka Y (ed).
[Metabolic Maps] (In Japanese)
Tokyo Kagaku Dojin (1980)
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
[Cellular Functions and Metabolic Maps] (In Japanese)
Tokyo Kagaku Dojin (1997)
Michal G.
Biochemical Pathways
Wiley (1999)
mmu00020  Citrate cycle (TCA cycle)
mmu00030  Pentose phosphate pathway
mmu00500  Starch and sucrose metabolism
mmu00620  Pyruvate metabolism
mmu00640  Propanoate metabolism
KO pathway

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