KEGG   PATHWAY: dme03018
Entry
dme03018                    Pathway                                

Name
RNA degradation - Drosophila melanogaster (fruit fly)
Description
The correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay exist and both pathways are initiated by poly(A) shortening of the mRNA. In the 5' to 3' pathway, this is followed by decapping which then permits the 5' to 3' exonucleolytic degradation of transcripts. In the 3' to 5' pathway, the exosome, a large multisubunit complex, plays a key role. The exosome exists in archaeal cells, too. In bacteria, endoribonuclease E, a key enzyme involved in RNA decay and processing, organizes a protein complex called degradosome. RNase E or R interacts with the phosphate-dependent exoribonuclease polynucleotide phosphorylase, DEAD-box helicases, and additional factors in the RNA-degrading complex.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
dme03018  RNA degradation
dme03018

Other DBs
GO: 0006401
Organism
Drosophila melanogaster (fruit fly) [GN:dme]
Gene
Dmel_CG2091  CG2091; uncharacterized protein [KO:K12584] [EC:3.6.1.59]
Dmel_CG6249  Csl4; Csl4 [KO:K07573]
Dmel_CG3931  Rrp4; Rrp4, isoform B [KO:K03679]
Dmel_CG31938  Rrp40; ribosomal RNA processing 40, isoform B [KO:K03681]
Dmel_CG8025  Mtr3; Mtr3 [KO:K12587]
Dmel_CG8395  Rrp42; Rrp42 [KO:K12589]
Dmel_CG15481  Ski6; Ski6, isoform B [KO:K11600]
Dmel_CG4043  Rrp46; Rrp46 [KO:K12590]
Dmel_CG9606  Rrp45; Rrp45, isoform B [KO:K03678]
Dmel_CG6413  Dis3; Dis3, isoform B [KO:K12585] [EC:3.1.13.-]
Dmel_CG7292  Rrp6; Rrp6, isoform B [KO:K12591] [EC:3.1.13.-]
Dmel_CG8928  Rrp47; ribosomal RNA processing 47, isoform B [KO:K12592]
Dmel_CG9250  Mpp6; M-phase phosphoprotein 6, isoform B [KO:K12593]
Dmel_CG11265  Trf4-1; topoisomerase related function 4-1, isoform J [KO:K03514] [EC:2.7.7.19]
Dmel_CG17462  Trf4-2; topoisomerase related function 4-2, isoform B [KO:K03514] [EC:2.7.7.19]
Dmel_CG4152  Mtr4; Mtr4 helicase [KO:K12598] [EC:3.6.4.13]
Dmel_CG10210  tst; twister, isoform B [KO:K12599] [EC:3.6.4.-]
Dmel_CG8777  CG8777; uncharacterized protein [KO:K12600]
Dmel_CG3909  CG3909; uncharacterized protein [KO:K12602]
Dmel_CG31137  twin; twin, isoform C [KO:K12603] [EC:3.1.13.4]
Dmel_CG34407  Not1; Not1, isoform C [KO:K12604]
Dmel_CG2161  Rga; regena, isoform A [KO:K12605]
Dmel_CG15262  CG15262; uncharacterized protein [KO:K12605]
Dmel_CG8426  Not3; CCR4-NOT transcription complex subunit 3, isoform B [KO:K12580]
Dmel_CG31716  Cnot4; CCR4-NOT transcription complex subunit 4, isoform H [KO:K10643] [EC:2.3.2.27]
Dmel_CG5684  Pop2; Pop2, isoform D [KO:K12581]
Dmel_CG14213  Rcd-1; required for cell differentiation 1, isoform C [KO:K12606]
Dmel_CG9573  Rcd-1r; Rcd-1 related [KO:K12606]
Dmel_CG18616  Not10; CCR4-NOT transcription complex subunit 10, isoform B [KO:K12607]
Dmel_CG9323  Rhau; RHAU helicase, isoform B [KO:K14442] [EC:3.6.4.13]
Dmel_CG9214  Tob; transducer of ERBB2, isoform C [KO:K14443]
Dmel_CG5119  pAbp; poly(A) binding protein, isoform A [KO:K13126]
Dmel_CG8232  PAN2; Poly(A)-binding protein-dependent poly(A) ribonuclease 2, isoform A [KO:K12571] [EC:3.1.13.4]
Dmel_CG11486  PAN3; Poly(A) specific ribonuclease subunit PAN3, isoform G [KO:K12572]
Dmel_CG11183  DCP1; decapping protein 1, isoform B [KO:K12611] [EC:3.-.-.-]
Dmel_CG6169  DCP2; decapping protein 2, isoform D [KO:K12613] [EC:3.6.1.62]
Dmel_CG4916  me31B; maternal expression at 31B, isoform A [KO:K12614] [EC:3.6.4.13]
Dmel_CG6311  Edc3; enhancer of decapping 3 [KO:K12615]
Dmel_CG6181  Ge-1; Ge-1, isoform A [KO:K12616]
Dmel_CG5208  Patr-1; protein associated with topo II related - 1, isoform B [KO:K12617]
Dmel_CG3291  pcm; pacman, isoform B [KO:K12618] [EC:3.1.13.-]
Dmel_CG10354  Rat1; Rat1 5'-3' exoribonuclease, isoform B [KO:K12619] [EC:3.1.13.-]
Dmel_CG4279  LSm1; like Sm 1 [KO:K12620]
Dmel_CG10418  CG10418; uncharacterized protein [KO:K12621]
Dmel_CG31184  LSm3; like Sm 3, isoform B [KO:K12622]
Dmel_CG17768  CG17768; uncharacterized protein, isoform A [KO:K12623]
Dmel_CG6610  CG6610; uncharacterized protein, isoform B [KO:K12624]
Dmel_CG9344  CG9344; uncharacterized protein [KO:K12625]
Dmel_CG13277  LSm7; like Sm 7, isoform B [KO:K12626]
Dmel_CG2021  CG2021; uncharacterized protein [KO:K12627]
Dmel_CG17654  Eno; enolase, isoform B [KO:K01689] [EC:4.2.1.11]
Dmel_CG11337  PNPase; polynucleotide phosphorylase, isoform E [KO:K00962] [EC:2.7.7.8]
Dmel_CG4001  Pfk; phosphofructokinase, isoform B [KO:K00850] [EC:2.7.1.11]
Dmel_CG8542  Hsc70-5; heat shock protein cognate 5, isoform B [KO:K04043]
Dmel_CG12101  Hsp60A; heat shock protein 60A, isoform A [KO:K04077]
Dmel_CG7235  Hsp60C; heat shock protein 60C, isoform C [KO:K04077]
Dmel_CG16954  Hsp60D; heat shock protein 60D, isoform A [KO:K04077]
Dmel_CG2830  Hsp60B; heat shock protein 60B [KO:K04077]
Reference
  Authors
Houseley J, Tollervey D
  Title
The many pathways of RNA degradation.
  Journal
Cell 136:763-76 (2009)
DOI:10.1016/j.cell.2009.01.019
Reference
  Authors
Buttner K, Wenig K, Hopfner KP
  Title
The exosome: a macromolecular cage for controlled RNA degradation.
  Journal
Mol Microbiol 61:1372-9 (2006)
DOI:10.1111/j.1365-2958.2006.05331.x
Reference
  Authors
Schilders G, van Dijk E, Raijmakers R, Pruijn GJ
  Title
Cell and molecular biology of the exosome: how to make or break an RNA.
  Journal
Int Rev Cytol 251:159-208 (2006)
DOI:10.1016/S0074-7696(06)51005-8
Reference
  Authors
Hartung S, Hopfner KP
  Title
The exosome, plugged.
  Journal
EMBO Rep 8:456-7 (2007)
DOI:10.1038/sj.embor.7400961
Reference
  Authors
Carpousis AJ
  Title
The RNA degradosome of Escherichia coli: an mRNA-degrading machine assembled on RNase E.
  Journal
Annu Rev Microbiol 61:71-87 (2007)
DOI:10.1146/annurev.micro.61.080706.093440
Reference
  Authors
Marcaida MJ, DePristo MA, Chandran V, Carpousis AJ, Luisi BF
  Title
The RNA degradosome: life in the fast lane of adaptive molecular evolution.
  Journal
Trends Biochem Sci 31:359-65 (2006)
DOI:10.1016/j.tibs.2006.05.005
Reference
  Authors
Condon C
  Title
Maturation and degradation of RNA in bacteria.
  Journal
Curr Opin Microbiol 10:271-8 (2007)
DOI:10.1016/j.mib.2007.05.008
Related
pathway
dme03015  mRNA surveillance pathway
KO pathway
ko03018   

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