KEGG   PATHWAY: dro04024
Entry
dro04024                    Pathway                                
Name
cAMP signaling pathway - Desmodus rotundus (common vampire bat)
Description
cAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands including hormones, neurotransmitters, and other signaling molecules. cAMP regulates pivotal physiologic processes including metabolism, secretion, calcium homeostasis, muscle contraction, cell fate, and gene transcription. cAMP acts directly on three main targets: protein kinase A (PKA), the exchange protein activated by cAMP (Epac), and cyclic nucleotide-gated ion channels (CNGCs). PKA modulates, via phosphorylation, a number of cellular substrates, including transcription factors, ion channels, transporters, exchangers, intracellular Ca2+ -handling proteins, and the contractile machinery. Epac proteins function as guanine nucleotide exchange factors (GEFs) for both Rap1 and Rap2. Various effector proteins, including adaptor proteins implicated in modulation of the actin cytoskeleton, regulators of G proteins of the Rho family, and phospholipases, relay signaling downstream from Rap.
Class
Environmental Information Processing; Signal transduction
Pathway map
dro04024  cAMP signaling pathway
dro04024

Other DBs
GO: 0019933
Organism
Desmodus rotundus (common vampire bat) [GN:dro]
Gene
112296275  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
112296277  CNGA2; cyclic nucleotide-gated olfactory channel [KO:K04949]
112296379  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
112296519  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
112296598  SSTR1; somatostatin receptor type 1 [KO:K04217]
112296671  KCNK2; potassium channel subfamily K member 2 isoform X1 [KO:K04913]
112296715  CNGB1; LOW QUALITY PROTEIN: cyclic nucleotide-gated cation channel beta-1 [KO:K04952]
112296774  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
112297038  PLN; cardiac phospholamban [KO:K05852]
112297116  ADCY10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
112297129  [KO:K05264]
112297167  AFDN; afadin isoform X1 [KO:K05702]
112297282  VIP; VIP peptides [KO:K05264]
112297324  BVES; blood vessel epicardial substance [KO:K21108]
112297325  POPDC3; popeye domain-containing protein 3 [KO:K26207]
112297419  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
112297422  CGA; glycoprotein hormones alpha chain [KO:K08522]
112297427  HTR1E; 5-hydroxytryptamine receptor 1E [KO:K04153]
112297718  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
112297750  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
112297802  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
112297939  CALM2; calmodulin-2 [KO:K02183]
112298154  FSHR; follicle-stimulating hormone receptor isoform X1 [KO:K04247]
112298164  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
112298356  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
112298360  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
112298505  SSTR5; somatostatin receptor type 5 [KO:K04221]
112298654  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
112298663  ACOX1; peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:1.3.3.6]
112298813  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
112298903  GRIN2C; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2C [KO:K05211]
112298991  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
112299194  EDN2; endothelin-2 isoform X1 [KO:K16367]
112299258  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
112299448  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
112299479  HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153]
112299615  CALML6; calmodulin-like protein 6 [KO:K02183]
112299659  NPPA; natriuretic peptides A [KO:K12334]
112299769  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
112299790  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
112299910  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
112300171  ADRB1; beta-1 adrenergic receptor [KO:K04141]
112300407  CFTR; cystic fibrosis transmembrane conductance regulator isoform X1 [KO:K05031] [EC:5.6.1.6]
112300586  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
112301078  [KO:K02183]
112301115  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
112301126  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
112301133  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
112301160  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
112301280  GHRL; appetite-regulating hormone [KO:K05254]
112301287  OXTR; oxytocin receptor [KO:K04229]
112301477  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
112301523  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
112301683  HCN4; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 [KO:K04957]
112301746  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112302115  GABBR1; gamma-aminobutyric acid type B receptor subunit 1 isoform X1 [KO:K04615]
112302436  GLP1R; glucagon-like peptide 1 receptor [KO:K04581]
112302625  HTR1F; 5-hydroxytryptamine receptor 1F [KO:K04153]
112302724  GLI3; transcriptional activator GLI3 isoform X1 [KO:K06230]
112302742  PTCH1; protein patched homolog 1 isoform X1 [KO:K06225]
112303242  FSHB; follitropin subunit beta [KO:K05250]
112303291  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
112303343  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
112303376  RRAS2; ras-related protein R-Ras2 [KO:K07830]
112303430  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
112303463  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
112303586  EDN3; endothelin-3 [KO:K05227]
112303674  [KO:K05243]
112303826  [KO:K04632]
112303827  [KO:K04632]
112303838  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
112304037  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
112304374  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
112304506  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
112304550  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
112304763  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
112304801  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
112305116  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
112305224  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
112305250  SST; somatostatin [KO:K05237]
112305463  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
112305558  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
112305728  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
112306096  RYR2; ryanodine receptor 2 [KO:K04962]
112306277  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
112306573  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
112306844  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
112306861  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
112306888  ADCYAP1R1; pituitary adenylate cyclase-activating polypeptide type I receptor [KO:K04587]
112306927  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
112306974  CRHR2; corticotropin-releasing factor receptor 2 isoform X1 [KO:K04579]
112307006  NPY; pro-neuropeptide Y [KO:K05232]
112307173  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
112307376  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
112307458  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
112307510  F2R; proteinase-activated receptor 1 [KO:K03914]
112307557  [KO:K04513]
112307667  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112307981  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
112308323  VIPR2; vasoactive intestinal polypeptide receptor 2 [KO:K04590]
112308396  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
112308502  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
112308526  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
112309069  SUCNR1; LOW QUALITY PROTEIN: succinate receptor 1 [KO:K10042]
112309247  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
112309270  GHSR; growth hormone secretagogue receptor type 1 [KO:K04284]
112309297  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
112309331  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
112309395  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
112309401  EDN1; endothelin-1 isoform X1 [KO:K16366]
112309492  RHOA; transforming protein RhoA [KO:K04513]
112309828  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
112310002  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
112310074  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
112310162  RRAS; ras-related protein R-Ras [KO:K07829]
112310212  [KO:K08521]
112310453  HCAR2; LOW QUALITY PROTEIN: hydroxycarboxylic acid receptor 2 [KO:K08402]
112310477  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
112310607  ORAI1; calcium release-activated calcium channel protein 1 isoform X1 [KO:K16056]
112310624  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
112310655  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
112310725  ABCC4; multidrug resistance-associated protein 4 [KO:K05673]
112310822  GPR119; glucose-dependent insulinotropic receptor [KO:K08424]
112310823  ATP1B4; protein ATP1B4 isoform X1 [KO:K01540]
112310837  ADORA2A; adenosine receptor A2a [KO:K04266]
112310869  HCAR1; hydroxycarboxylic acid receptor 1 [KO:K08401]
112311117  GPHB5; glycoprotein hormone beta-5 [KO:K25484]
112311151  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
112311250  CALM1; calmodulin-1 [KO:K02183]
112311345  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
112311412  FOS; proto-oncogene c-Fos [KO:K04379]
112311458  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112311491  TSHR; thyrotropin receptor [KO:K04249]
112311702  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
112312275  AMH; muellerian-inhibiting factor [KO:K04665]
112312285  GRIN3B; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3B [KO:K05214]
112312292  HCN2; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 [KO:K04955]
112312372  GRIA2; glutamate receptor 2 isoform X1 [KO:K05198]
112312402  VAV1; proto-oncogene vav [KO:K05730]
112312435  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
112312452  HHIP; hedgehog-interacting protein [KO:K06231]
112312483  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
112312564  NPY1R; neuropeptide Y receptor type 1 [KO:K04204]
112312673  EDNRA; endothelin-1 receptor [KO:K04197]
112312688  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
112312801  CNGA4; cyclic nucleotide-gated cation channel alpha-4 [KO:K04951]
112312926  CALM3; calmodulin-3 [KO:K02183]
112312963  GIPR; gastric inhibitory polypeptide receptor isoform X1 [KO:K04580]
112313520  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
112313714  RAP1A; ras-related protein Rap-1A [KO:K04353]
112313776  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 isoform X1 [KO:K01539] [EC:7.2.2.13]
112313799  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
112313852  TNNI3; troponin I, cardiac muscle [KO:K12044]
112314072  TSHB; thyrotropin subunit beta [KO:K05251]
112314285  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
112314310  FXYD2; sodium/potassium-transporting ATPase subunit gamma isoform X1 [KO:K01538]
112314328  DRD2; D(2) dopamine receptor isoform X1 [KO:K04145]
112314466  [KO:K02649]
112314642  JUN; LOW QUALITY PROTEIN: transcription factor AP-1 [KO:K04448]
112314689  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
112314932  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
112315188  CNGA3; cyclic nucleotide-gated cation channel alpha-3 [KO:K04950]
112315346  CRH; corticoliberin [KO:K05256]
112315464  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
112315487  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
112315807  [KO:K01539] [EC:7.2.2.13]
112316047  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
112316237  GIP; gastric inhibitory polypeptide [KO:K05258]
112316287  CRHR1; corticotropin-releasing factor receptor 1 isoform X1 [KO:K04578]
112316334  PPP1R1B; protein phosphatase 1 regulatory subunit 1B isoform X1 [KO:K15494]
112316383  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
112316413  SOX9; transcription factor SOX-9 [KO:K18435]
112316572  SSTR2; somatostatin receptor type 2 [KO:K04218]
112316765  CNGA1; cGMP-gated cation channel alpha-1 [KO:K04948]
112316811  ACOX3; peroxisomal acyl-coenzyme A oxidase 3 isoform X1 [KO:K00232] [EC:1.3.3.6]
112316912  DRD5; D(1B) dopamine receptor [KO:K05840]
112317078  GPHA2; glycoprotein hormone alpha-2 [KO:K25483]
112317202  RELA; transcription factor p65 [KO:K04735]
112317227  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
112317249  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
112317275  BAD; bcl2-associated agonist of cell death [KO:K02158]
112317734  ATP1A2; sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
112317841  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
112317852  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
112317867  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
112318118  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 [KO:K12490]
112318292  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
112318404  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
112318651  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
112318673  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
112318756  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
112318875  ADORA1; adenosine receptor A1 [KO:K04265]
112318919  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112318977  RAP1B; ras-related protein Rap-1b [KO:K07836]
112319099  GLI1; zinc finger protein GLI1 isoform X1 [KO:K16797]
112319335  HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153]
112319547  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
112319549  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
112319561  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
112319603  ADRB2; beta-2 adrenergic receptor [KO:K04142]
112319624  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
112319688  DRD1; D(1A) dopamine receptor [KO:K04144]
112320130  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112320160  FFAR2; free fatty acid receptor 2 [KO:K04328]
112320186  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 [KO:K01539] [EC:7.2.2.13]
112320227  FXYD1; phospholemman [KO:K13360]
112320229  LIPE; hormone-sensitive lipase [KO:K07188] [EC:3.1.1.79]
112320488  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
112320573  POPDC2; popeye domain-containing protein 2 isoform X1 [KO:K26206]
112321008  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
112321016  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
112321019  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
112321120  [KO:K02183]
112321127  HTR1A; 5-hydroxytryptamine receptor 1A [KO:K04153]
112321623  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
112321719  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
112321755  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
112322163  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
112322296  GCG; LOW QUALITY PROTEIN: glucagon [KO:K05259]
112322357  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
112322556  MC2R; adrenocorticotropic hormone receptor [KO:K04200]
112322654  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
112322808  ADCYAP1; pituitary adenylate cyclase-activating polypeptide [KO:K05262]
112322916  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
112322988  CALML3; calmodulin-like protein 3 [KO:K02183]
Compound
C00020  AMP
C00042  Succinate
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00186  (S)-Lactate
C00212  Adenosine
C00238  Potassium cation
C00288  HCO3-
C00334  4-Aminobutanoate
C00416  Phosphatidate
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00698  Cl-
C00780  Serotonin
C00788  L-Adrenaline
C01089  (R)-3-Hydroxybutanoate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C01330  Sodium cation
C01996  Acetylcholine
C03758  Dopamine
C20792  Oleoylethanolamide
C20793  3-Hydroxyoctanoate
Reference
PMID:11493633
  Authors
Fimia GM, Sassone-Corsi P
  Title
Cyclic AMP signalling.
  Journal
J Cell Sci 114:1971-2 (2001)
Reference
PMID:18323530
  Authors
Serezani CH, Ballinger MN, Aronoff DM, Peters-Golden M
  Title
Cyclic AMP: master regulator of innate immune cell function.
  Journal
Am J Respir Cell Mol Biol 39:127-32 (2008)
DOI:10.1165/rcmb.2008-0091TR
Reference
PMID:24281338
  Authors
Oldenburger A, Maarsingh H, Schmidt M
  Title
Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung.
  Journal
Pharmaceuticals (Basel) 5:1291-331 (2012)
DOI:10.3390/ph5121291
Reference
PMID:24613710
  Authors
Ahuja M, Jha A, Maleth J, Park S, Muallem S
  Title
cAMP and Ca signaling in secretory epithelia: Crosstalk and synergism.
  Journal
Cell Calcium 55:385-393 (2014)
DOI:10.1016/j.ceca.2014.01.006
Reference
PMID:22082266
  Authors
Shirshev SV
  Title
Role of Epac proteins in mechanisms of cAMP-dependent immunoregulation.
  Journal
Biochemistry (Mosc) 76:981-98 (2011)
DOI:10.1134/S000629791109001X
Reference
PMID:18176800
  Authors
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J Am Coll Cardiol 54:1747-62 (2009)
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Prog Biophys Mol Biol 85:261-78 (2004)
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Front Physiol 2:67 (2011)
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Front Behav Neurosci 5:45 (2011)
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Trends Neurosci 16:233-40 (1993)
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Front Cell Neurosci 7:157 (2013)
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Mol Endocrinol 14:1962-75 (2000)
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Epac/Rap and PKA are novel mechanisms of ANP-induced Rac-mediated pulmonary endothelial barrier protection.
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J Cell Physiol 215:715-24 (2008)
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Related
pathway
dro00071  Fatty acid degradation
dro04015  Rap1 signaling pathway
dro04020  Calcium signaling pathway
dro04151  PI3K-Akt signaling pathway
dro04210  Apoptosis
dro04260  Cardiac muscle contraction
dro04340  Hedgehog signaling pathway
dro04720  Long-term potentiation
dro04740  Olfactory transduction
dro04972  Pancreatic secretion
dro04976  Bile secretion
KO pathway
ko04024   

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