Entry
Name
Cardiac muscle contraction - Gallus gallus (chicken)
Description
Contraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation of voltage-dependent L-type Ca channels (DHP receptors) upon membrane depolarization triggers the release of Ca2+ via Ca2+ release channels (ryanodine receptors) of sarcoplasmic reticulum (SR) through a Ca2+ -induced Ca release (CICR) mechanism. Ca2+ ions released via the CICR mechanism diffuse through the cytosolic space to contractile proteins to bind to troponinC resulting in the release of inhibition induced by troponinI. The Ca2+ binding to troponinC thereby triggers the sliding of thin and thick filaments, that is, the activation of a crossbridge and subsequent cardiac force development and/or cell shortening. Recovery occurs as Ca2+ is pumped out of the cell by the Na+/Ca2+ exchanger (NCX) or is returned to the sarcoplasmic reticulum (SR) by sarco(endo)plasmic Ca2+ -ATPase (SERCA) pumps on the non-junctional region of the SR.
Class
Organismal Systems; Circulatory system
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Gallus gallus (chicken) [GN:
gga ]
Gene
395891 CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850 ]
395895 CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851 ]
395985 CATSPER2; voltage-dependent L-type calcium channel subunit alpha-1S isoform 1 [KO:K04857 ]
777366 CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862 ]
428420 CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863 ]
107050029 voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864 ]
374259 CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform a [KO:K04865 ]
768444 CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 preproprotein [KO:K04858 ]
430150 CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859 ]
415996 CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X2 [KO:K04860 ]
100858946 CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861 ]
417428 CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866 ]
427909 CACNG2; voltage-dependent calcium channel gamma-2 subunit isoform X2 [KO:K04867 ]
395378 CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868 ]
373924 CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869 ]
417429 CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870 ]
107050634 CACNG7; LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-7 subunit [KO:K04872 ]
396446 ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform 2 [KO:K05853 ] [EC:7.2.2.10 ]
396032 TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865 ]
396433 TNNT2; troponin T, cardiac muscle isoforms [KO:K12045 ]
770103 TPM3; tropomyosin alpha-3 chain isoform a [KO:K09290 ]
416874 MYL2; myosin regulatory light chain 2A, cardiac muscle isoform [KO:K10351 ]
396067 MYL3; myosin light chain 1, cardiac muscle [KO:K12749 ]
415752 UQCRFS1; cytochrome b-c1 complex subunit Rieske, mitochondrial precursor [KO:K00411 ] [EC:7.1.1.8 ]
416013 UQCRC1; cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414 ]
427009 UQCRC2; cytochrome b-c1 complex subunit 2, mitochondrial isoform X2 [KO:K00415 ]
771939 UQCRH; cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416 ]
770937 UQCR10; cytochrome b-c1 complex subunit 9 [KO:K00419 ]
770135 UQCR11; cytochrome b-c1 complex subunit 10 [KO:K00420 ]
415826 COX4I2; cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263 ]
769735 COX5A; cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264 ]
416978 COX6A1; cytochrome c oxidase subunit VIa polypeptide 1 isoform 1 [KO:K02266 ]
421392 COX7A2L; cytochrome c oxidase subunit VIIa polypeptide 2 like isoform 1 [KO:K02270 ]
772260 COX7A2; cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270 ]
771947 COX7B; cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271 ]
431629 COX7C; cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272 ]
395759 SLC8A3; sodium/calcium exchanger 3 precursor [KO:K05849 ]
395760 SLC8A1; sodium/calcium exchanger 1 precursor [KO:K05849 ]
418676 SLC9A7; sodium/hydrogen exchanger 7 isoform X1 [KO:K12041 ]
396530 ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 precursor [KO:K01539 ] [EC:7.2.2.13 ]
396529 ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540 ]
396549 ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540 ]
419770 FXYD2; sodium/potassium-transporting ATPase subunit gamma [KO:K01538 ]
419580 SLC9A1; sodium/hydrogen exchanger 1 precursor [KO:K05742 ]
Compound
Reference
Authors
Bers DM
Title
Calcium cycling and signaling in cardiac myocytes.
Journal
Reference
Authors
Bers DM
Title
Cardiac excitation-contraction coupling.
Journal
Reference
Authors
Endoh M
Title
Signal transduction and Ca2+ signaling in intact myocardium.
Journal
Reference
Authors
Endoh M
Title
Cardiac Ca2+ signaling and Ca2+ sensitizers.
Journal
Reference
Authors
Bers DM, Despa S
Title
Cardiac myocytes Ca2+ and Na+ regulation in normal and failing hearts.
Journal
Reference
Authors
Gordon AM, Homsher E, Regnier M
Title
Regulation of contraction in striated muscle.
Journal
Reference
Authors
Phrommintikul A, Chattipakorn N
Title
Roles of cardiac ryanodine receptor in heart failure and sudden cardiac death.
Journal
Reference
Authors
Lacinova L
Title
Voltage-dependent calcium channels.
Journal
Gen Physiol Biophys 24 Suppl 1:1-78 (2005)
Reference
Authors
Lingrel J, Moseley A, Dostanic I, Cougnon M, He S, James P, Woo A, O'Connor K, Neumann J
Title
Functional roles of the alpha isoforms of the Na,K-ATPase.
Journal
Reference
Authors
Berg JS, Powell BC, Cheney RE
Title
A millennial myosin census.
Journal
Reference
Authors
Parmacek MS, Solaro RJ
Title
Biology of the troponin complex in cardiac myocytes.
Journal
Reference
Authors
Yamashita H, Sugiura S, Fujita H, Yasuda S, Nagai R, Saeki Y, Sunagawa K, Sugi H
Title
Myosin light chain isoforms modify force-generating ability of cardiac myosin by changing the kinetics of actin-myosin interaction.
Journal
Reference
Authors
Pritchard TJ, Kranias EG
Title
Junctin and the histidine-rich Ca2+ binding protein: potential roles in heart failure and arrhythmogenesis.
Journal
Reference
Authors
Landstrom AP, Dobrev D, Wehrens XHT
Title
Calcium Signaling and Cardiac Arrhythmias.
Journal
Related pathway
KO pathway