KEGG   PATHWAY: mmu03320
Entry
mmu03320                    Pathway                                
Name
PPAR signaling pathway - Mus musculus (house mouse)
Description
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake.
Class
Organismal Systems; Endocrine system
Pathway map
mmu03320  PPAR signaling pathway
mmu03320

Organism
Mus musculus (house mouse) [GN:mmu]
Gene
100040843  Cyp4a32; cytochrome P450, family 4, subfamily a, polypeptide 32 [KO:K07425] [EC:1.14.14.80]
103968  Plin1; perilipin 1 [KO:K08768]
104086  Cyp27a1; cytochrome P450, family 27, subfamily a, polypeptide 1 [KO:K00488] [EC:1.14.15.15]
108078  Olr1; oxidized low density lipoprotein (lectin-like) receptor 1 [KO:K08763]
109264  Me3; malic enzyme 3, NADP(+)-dependent, mitochondrial [KO:K00029] [EC:1.1.1.40]
11363  Acadl; acyl-Coenzyme A dehydrogenase, long-chain [KO:K00255] [EC:1.3.8.8]
11364  Acadm; acyl-Coenzyme A dehydrogenase, medium chain [KO:K00249] [EC:1.3.8.7]
113868  Acaa1a; acetyl-Coenzyme A acyltransferase 1A [KO:K07513] [EC:2.3.1.16]
11430  Acox1; acyl-Coenzyme A oxidase 1, palmitoyl [KO:K00232] [EC:1.3.3.6]
11450  Adipoq; adiponectin, C1Q and collagen domain containing [KO:K07296]
11520  Plin2; perilipin 2 [KO:K17284]
11770  Fabp4; fatty acid binding protein 4, adipocyte [KO:K08753]
11806  Apoa1; apolipoprotein A-I [KO:K08757]
11807  Apoa2; apolipoprotein A-II [KO:K08758]
11814  Apoc3; apolipoprotein C-III [KO:K08759]
11832  Aqp7; aquaporin 7 [KO:K08771]
12140  Fabp7; fatty acid binding protein 7, brain [KO:K08756]
12491  Cd36; CD36 molecule [KO:K06259]
12894  Cpt1a; carnitine palmitoyltransferase 1a, liver [KO:K08765] [EC:2.3.1.21]
12895  Cpt1b; carnitine palmitoyltransferase 1b, muscle [KO:K19523] [EC:2.3.1.21]
12896  Cpt2; carnitine palmitoyltransferase 2 [KO:K08766] [EC:2.3.1.21]
13117  Cyp4a10; cytochrome P450, family 4, subfamily a, polypeptide 10 [KO:K07425] [EC:1.14.14.80]
13118  Cyp4a12b; cytochrome P450, family 4, subfamily a, polypeptide 12B [KO:K07425] [EC:1.14.14.80]
13119  Cyp4a14; cytochrome P450, family 4, subfamily a, polypeptide 14 [KO:K07425] [EC:1.14.14.80]
13122  Cyp7a1; cytochrome P450, family 7, subfamily a, polypeptide 1 [KO:K00489] [EC:1.14.14.23]
13124  Cyp8b1; cytochrome P450, family 8, subfamily b, polypeptide 1 [KO:K07431] [EC:1.14.14.139]
13167  Dbi; diazepam binding inhibitor [KO:K08762]
13168  Dbil5; diazepam binding inhibitor-like 5 [KO:K08762]
14077  Fabp3; fatty acid binding protein 3, muscle and heart [KO:K08752]
14079  Fabp2; fatty acid binding protein 2, intestinal [KO:K08751]
14080  Fabp1; fatty acid binding protein 1, liver [KO:K08750]
14081  Acsl1; acyl-CoA synthetase long-chain family member 1 [KO:K01897] [EC:6.2.1.3]
14625  Gykl1; glycerol kinase-like 1 [KO:K00864] [EC:2.7.1.30]
14626  Gk2; glycerol kinase 2 [KO:K00864] [EC:2.7.1.30]
14933  Gk; glycerol kinase [KO:K00864] [EC:2.7.1.30]
15360  Hmgcs2; 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 [KO:K01641] [EC:2.3.3.10]
16202  Ilk; integrin linked kinase [KO:K06272] [EC:2.7.11.1]
16204  Fabp6; fatty acid binding protein 6 [KO:K08755]
16592  Fabp5; fatty acid binding protein 5, epidermal [KO:K08754]
16956  Lpl; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
17436  Me1; malic enzyme 1, NADP(+)-dependent, cytosolic [KO:K00029] [EC:1.1.1.40]
18534  Pck1; phosphoenolpyruvate carboxykinase 1, cytosolic [KO:K01596] [EC:4.1.1.32]
18607  Pdpk1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
18830  Pltp; phospholipid transfer protein [KO:K08761]
19013  Ppara; peroxisome proliferator activated receptor alpha [KO:K07294]
19015  Ppard; peroxisome proliferator activator receptor delta [KO:K04504]
19016  Pparg; peroxisome proliferator activated receptor gamma [KO:K08530]
20181  Rxra; retinoid X receptor alpha [KO:K08524]
20182  Rxrb; retinoid X receptor beta [KO:K08525]
20183  Rxrg; retinoid X receptor gamma [KO:K08526]
20249  Scd1; stearoyl-Coenzyme A desaturase 1 [KO:K00507] [EC:1.14.19.1]
20250  Scd2; stearoyl-Coenzyme A desaturase 2 [KO:K00507] [EC:1.14.19.1]
20280  Scp2; sterol carrier protein 2, liver [KO:K08764] [EC:2.3.1.176]
20411  Sorbs1; sorbin and SH3 domain containing 1 [KO:K06086]
208715  Hmgcs1; 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 [KO:K01641] [EC:2.3.3.10]
216739  Acsl6; acyl-CoA synthetase long-chain family member 6 [KO:K01897] [EC:6.2.1.3]
22190  Ubc; ubiquitin C [KO:K08770]
22227  Ucp1; uncoupling protein 1 (mitochondrial, proton carrier) [KO:K08769]
22259  Nr1h3; nuclear receptor subfamily 1, group H, member 3 [KO:K08536]
225579  Slc27a6; solute carrier family 27 (fatty acid transporter), member 6 [KO:K08749]
230639  Cyp4a29; cytochrome P450, family 4, subfamily a, polypeptide 29 [KO:K07425] [EC:1.14.14.80]
235674  Acaa1b; acetyl-Coenzyme A acyltransferase 1B [KO:K07513] [EC:2.3.1.16]
26457  Slc27a1; solute carrier family 27 (fatty acid transporter), member 1 [KO:K08745] [EC:6.2.1.-]
26458  Slc27a2; solute carrier family 27 (fatty acid transporter), member 2 [KO:K08746] [EC:6.2.1.- 6.2.1.3]
26459  Slc27a5; solute carrier family 27 (fatty acid transporter), member 5 [KO:K08748] [EC:6.2.1.7]
26569  Slc27a4; solute carrier family 27 (fatty acid transporter), member 4 [KO:K08745] [EC:6.2.1.-]
277753  Cyp4a12a; cytochrome P450, family 4, subfamily a, polypeptide 12a [KO:K07425] [EC:1.14.14.80]
30049  Scd3; stearoyl-coenzyme A desaturase 3 [KO:K00507] [EC:1.14.19.1]
328845  Acsbg2; acyl-CoA synthetase bubblegum family member 2 [KO:K15013] [EC:6.2.1.3]
329065  Scd4; stearoyl-coenzyme A desaturase 4 [KO:K00507] [EC:1.14.19.1]
433256  Acsl5; acyl-CoA synthetase long-chain family member 5 [KO:K01897] [EC:6.2.1.3]
435802  Cyp4a30b; cytochrome P450, family 4, subfamily a, polypeptide 30b [KO:K07425] [EC:1.14.14.80]
50790  Acsl4; acyl-CoA synthetase long-chain family member 4 [KO:K01897] [EC:6.2.1.3]
56473  Fads2; fatty acid desaturase 2 [KO:K10226] [EC:1.14.19.3]
57435  Plin4; perilipin 4 [KO:K20254]
57875  Angptl4; angiopoietin-like 4 [KO:K08767]
66113  Apoa5; apolipoprotein A-V [KO:K09025]
666168  Cyp4a31; cytochrome P450, family 4, subfamily a, polypeptide 31 [KO:K07425] [EC:1.14.14.80]
66968  Plin5; perilipin 5 [KO:K20255]
74147  Ehhadh; enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
74205  Acsl3; acyl-CoA synthetase long-chain family member 3 [KO:K01897] [EC:6.2.1.3]
74551  Pck2; phosphoenolpyruvate carboxykinase 2 (mitochondrial) [KO:K01596] [EC:4.1.1.32]
78070  Cpt1c; carnitine palmitoyltransferase 1c [KO:K19524] [EC:2.3.1.21]
78625  Acsbg3; acyl-CoA synthetase bubblegum family member 3 [KO:K15013] [EC:6.2.1.3]
80911  Acox3; acyl-Coenzyme A oxidase 3, pristanoyl [KO:K00232] [EC:1.3.3.6]
83995  Mmp1a; matrix metallopeptidase 1a (interstitial collagenase) [KO:K01388] [EC:3.4.24.7]
83996  Mmp1b; matrix metallopeptidase 1b (interstitial collagenase) [KO:K01388] [EC:3.4.24.7]
93732  Acox2; acyl-Coenzyme A oxidase 2, branched chain [KO:K10214] [EC:1.17.99.3]
94180  Acsbg1; acyl-CoA synthetase bubblegum family member 1 [KO:K15013] [EC:6.2.1.3]
Compound
C02165  Leukotriene B4
C14762  13(S)-HODE
C14767  9(S)-HODE
C14776  8(S)-HETE
C15493  9-cis-Retinoic acid
Reference
PMID:15828220
  Authors
Takahashi N, Goto T, Kusudo T, Moriyama T, Kawada T.
  Title
[The structures and functions of peroxisome proliferator-activated receptors (PPARs)]
  Journal
Nippon Rinsho 63:557-64 (2005)
Reference
PMID:15828221
  Authors
Fujii H.
  Title
[PPARs-mediated intracellular signal transduction]
  Journal
Nippon Rinsho 63:565-71 (2005)
Reference
PMID:15828222
  Authors
Takada I, Kato S.
  Title
[PPARs target genes]
  Journal
Nippon Rinsho 63:573-7 (2005)
Reference
PMID:15828223
  Authors
Inoue H.
  Title
[Endogenous ligands for PPARs]
  Journal
Nippon Rinsho 63:578-83 (2005)
Reference
PMID:16476485
  Authors
Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W.
  Title
From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions.
  Journal
Prog Lipid Res 45:120-59 (2006)
DOI:10.1016/j.plipres.2005.12.002
Reference
PMID:16601267
  Authors
Desvergne B, Michalik L, Wahli W.
  Title
Transcriptional regulation of metabolism.
  Journal
Physiol Rev 86:465-514 (2006)
DOI:10.1152/physrev.00025.2005
Reference
PMID:14999402
  Authors
Mandard S, Muller M, Kersten S.
  Title
Peroxisome proliferator-activated receptor alpha target genes.
  Journal
Cell Mol Life Sci 61:393-416 (2004)
DOI:10.1007/s00018-003-3216-3
Reference
PMID:10529898
  Authors
Desvergne B, Wahli W.
  Title
Peroxisome proliferator-activated receptors: nuclear control of metabolism.
  Journal
Endocr Rev 20:649-88 (1999)
DOI:10.1210/edrv.20.5.0380
Reference
PMID:15673477
  Authors
Savage DB.
  Title
PPARgamma as a metabolic regulator: insights from genomics and pharmacology.
  Journal
Expert Rev Mol Med 2005:1-16 (2005)
DOI:10.1017/S1462399405008793
Reference
PMID:16511590
  Authors
Semple RK, Chatterjee VK, O'Rahilly S.
  Title
PPAR gamma and human metabolic disease.
  Journal
J Clin Invest 116:581-9 (2006)
DOI:10.1172/JCI28003
Reference
PMID:16360030
  Authors
Lehrke M, Lazar MA.
  Title
The many faces of PPARgamma.
  Journal
Cell 123:993-9 (2005)
DOI:10.1016/j.cell.2005.11.026
Reference
PMID:11921433
  Authors
Hauner H.
  Title
The mode of action of thiazolidinediones.
  Journal
Diabetes Metab Res Rev 18 Suppl 2:S10-5 (2002)
DOI:10.1002/dmrr.249
Related
pathway
mmu00071  Fatty acid degradation
mmu00120  Primary bile acid biosynthesis
mmu00564  Glycerophospholipid metabolism
mmu04920  Adipocytokine signaling pathway
KO pathway
ko03320   

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