PATHWAY: mmu03320 Help
Entry
Name
PPAR signaling pathway - Mus musculus (house mouse)
Description
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake.
Class
Organismal Systems; Endocrine system
BRITE hierarchy
Pathway map
Ortholog table
Organism
Mus musculus (house mouse) [GN:
mmu ]
Gene
26457 Slc27a1; solute carrier family 27 (fatty acid transporter), member 1 [KO:K08745 ] [EC:6.2.1.-]
26569 Slc27a4; solute carrier family 27 (fatty acid transporter), member 4 [KO:K08745 ] [EC:6.2.1.-]
26458 Slc27a2; solute carrier family 27 (fatty acid transporter), member 2 [KO:K08746 ] [EC:6.2.1.- 6.2.1.3 ]
26459 Slc27a5; solute carrier family 27 (fatty acid transporter), member 5 [KO:K08748 ] [EC:6.2.1.7 ]
225579 Slc27a6; solute carrier family 27 (fatty acid transporter), member 6 [KO:K08749 ]
14080 Fabp1; fatty acid binding protein 1, liver [KO:K08750 ]
14079 Fabp2; fatty acid binding protein 2, intestinal [KO:K08751 ]
14077 Fabp3; fatty acid binding protein 3, muscle and heart [KO:K08752 ]
11770 Fabp4; fatty acid binding protein 4, adipocyte [KO:K08753 ]
16592 Fabp5; fatty acid binding protein 5, epidermal [KO:K08754 ]
12140 Fabp7; fatty acid binding protein 7, brain [KO:K08756 ]
19013 Ppara; peroxisome proliferator activated receptor alpha [KO:K07294 ]
19015 Ppard; peroxisome proliferator activator receptor delta [KO:K04504 ]
19016 Pparg; peroxisome proliferator activated receptor gamma [KO:K08530 ]
22259 Nr1h3; nuclear receptor subfamily 1, group H, member 3 [KO:K08536 ]
13168 Dbil5; diazepam binding inhibitor-like 5 [KO:K08762 ]
108078 Olr1; oxidized low density lipoprotein (lectin-like) receptor 1 [KO:K08763 ]
20411 Sorbs1; sorbin and SH3 domain containing 1 [KO:K06086 ]
11450 Adipoq; adiponectin, C1Q and collagen domain containing [KO:K07296 ]
22227 Ucp1; uncoupling protein 1 (mitochondrial, proton carrier) [KO:K08769 ]
Compound
Reference
Authors
Takahashi N, Goto T, Kusudo T, Moriyama T, Kawada T.
Title
[The structures and functions of peroxisome proliferator-activated receptors (PPARs)]
Journal
Nippon Rinsho 63:557-64 (2005)
Reference
Authors
Fujii H.
Title
[PPARs-mediated intracellular signal transduction]
Journal
Nippon Rinsho 63:565-71 (2005)
Reference
Authors
Takada I, Kato S.
Title
[PPARs target genes]
Journal
Nippon Rinsho 63:573-7 (2005)
Reference
Authors
Inoue H.
Title
[Endogenous ligands for PPARs]
Journal
Nippon Rinsho 63:578-83 (2005)
Reference
Authors
Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W.
Title
From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions.
Journal
Reference
Authors
Desvergne B, Michalik L, Wahli W.
Title
Transcriptional regulation of metabolism.
Journal
Reference
Authors
Mandard S, Muller M, Kersten S.
Title
Peroxisome proliferator-activated receptor alpha target genes.
Journal
Reference
Authors
Desvergne B, Wahli W.
Title
Peroxisome proliferator-activated receptors: nuclear control of metabolism.
Journal
Reference
Authors
Savage DB.
Title
PPARgamma as a metabolic regulator: insights from genomics and pharmacology.
Journal
Reference
Authors
Semple RK, Chatterjee VK, O'Rahilly S.
Title
PPAR gamma and human metabolic disease.
Journal
Reference
Authors
Lehrke M, Lazar MA.
Title
The many faces of PPARgamma.
Journal
Reference
Authors
Hauner H.
Title
The mode of action of thiazolidinediones.
Journal
Related pathway
mmu04920 Adipocytokine signaling pathway
KO pathway