Entry |
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Name |
VEGF signaling pathway - Mus musculus (mouse)
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Description |
There is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic angiogenesis. The binding of VEGF to VEGFR-2 leads to a cascade of different signaling pathways, resulting in the up-regulation of genes involved in mediating the proliferation and migration of endothelial cells and promoting their survival and vascular permeability. For example, the binding of VEGF to VEGFR-2 leads to dimerization of the receptor, followed by intracellular activation of the PLCgamma;PKC-Raf kinase-MEK-mitogen-activated protein kinase (MAPK) pathway and subsequent initiation of DNA synthesis and cell growth, whereas activation of the phosphatidylinositol 3' -kinase (PI3K)-Akt pathway leads to increased endothelial-cell survival. Activation of PI3K, FAK, and p38 MAPK is implicated in cell migration signaling.
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Class |
Environmental Information Processing; Signal transduction
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Pathway map |

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Other DBs |
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Organism |
Mus musculus (mouse) [GN: mmu]
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Gene |
22339 | Vegfa; vascular endothelial growth factor A [KO:K05448] |
15461 | Hras; Harvey rat sarcoma virus oncogene [KO:K02833] |
16653 | Kras; Kirsten rat sarcoma viral oncogene homolog [KO:K07827] |
18783 | Pla2g4a; phospholipase A2, group IVA (cytosolic, calcium-dependent) [KO:K16342] [EC:3.1.1.4] |
232889 | Pla2g4c; phospholipase A2, group IVC (cytosolic, calcium-independent) [KO:K16342] [EC:3.1.1.4] |
19057 | Ppp3cc; protein phosphatase 3, catalytic subunit, gamma isoform [KO:K04348] [EC:3.1.3.16] |
19055 | Ppp3ca; protein phosphatase 3, catalytic subunit, alpha isoform [KO:K04348] [EC:3.1.3.16] |
19058 | Ppp3r1; protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) [KO:K06268] |
19059 | Ppp3r2; protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II) [KO:K06268] |
18019 | Nfatc2; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 [KO:K17332] |
216148 | Shc2; SHC (Src homology 2 domain containing) transforming protein 2 [KO:K17447] |
102626 | Mapkapk3; mitogen-activated protein kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1] |
18706 | Pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153] |
18707 | Pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153] |
74769 | Pik3cb; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153] |
18709 | Pik3r2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649] |
18708 | Pik3r1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649] |
18710 | Pik3r3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649] |
12015 | Bad; BCL2-associated agonist of cell death [KO:K02158] |
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Compound |
C01245 | D-myo-Inositol 1,4,5-trisphosphate |
C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
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Reference |
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Authors |
Cross MJ, Dixelius J, Matsumoto T, Claesson-Welsh L. |
Title |
VEGF-receptor signal transduction. |
Journal |
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Reference |
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Authors |
Matsumoto T, Claesson-Welsh L. |
Title |
VEGF receptor signal transduction. |
Journal |
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Reference |
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Authors |
Hoeben A, Landuyt B, Highley MS, Wildiers H, Van Oosterom AT, De Bruijn EA. |
Title |
Vascular endothelial growth factor and angiogenesis. |
Journal |
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Reference |
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Authors |
Takahashi H, Shibuya M. |
Title |
The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions. |
Journal |
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Reference |
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Authors |
Zachary I. |
Title |
VEGF signalling: integration and multi-tasking in endothelial cell biology. |
Journal |
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Reference |
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Authors |
Munoz-Chapuli R, Quesada AR, Angel Medina M. |
Title |
Angiogenesis and signal transduction in endothelial cells. |
Journal |
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Reference |
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Authors |
Lamalice L, Houle F, Jourdan G, Huot J. |
Title |
Phosphorylation of tyrosine 1214 on VEGFR2 is required for VEGF-induced activation of Cdc42 upstream of SAPK2/p38. |
Journal |
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Reference |
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Authors |
Shu X, Wu W, Mosteller RD, Broek D. |
Title |
Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases. |
Journal |
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Related pathway |
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KO pathway |
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