KEGG   PATHWAY: bsu02010
Entry
bsu02010                    Pathway                                

Name
ABC transporters - Bacillus subtilis subsp. subtilis 168
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
bsu02010  ABC transporters
bsu02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Bacillus subtilis subsp. subtilis 168 [GN:bsu]
Gene
BSU08840  ssuA; aliphatic sulfonates-binding protein [KO:K15553]
BSU08850  ssuC; aliphatic sulfonates transport permease protein SsuC [KO:K15554]
BSU08830  ssuB; aliphatic sulfonates import ATP-binding protein SsuB [KO:K15555] [EC:7.6.2.14]
BSU33380  yvgL; ABC transporter substrate-binding protein [KO:K02020]
BSU33390  yvgM; molybdenum transport system permease protein YvgM [KO:K02018]
BSU03000  opuAC; glycine betaine-binding protein OpuAC [KO:K02002]
BSU02990  opuAB; glycine betaine transport system permease protein OpuAB [KO:K02001]
BSU02980  opuAA; glycine/betaine ABC transporter ATP-binding protein [KO:K02000] [EC:7.6.2.9]
BSU33710  opuBC; choline-binding protein [KO:K05845]
BSU33810  opuCC; glycine betaine/carnitine/choline-binding protein OpuCC [KO:K05845]
BSU33820  opuCB; glycine betaine/carnitine/choline transport system permease protein OpuCB [KO:K05846]
BSU33700  opuBD; choline transport system permease protein OpuBD [KO:K05846]
BSU33720  opuBB; choline transport system permease protein OpuBB [KO:K05846]
BSU33800  opuCD; glycine betaine/carnitine/choline transport system permease protein OpuCD [KO:K05846]
BSU33830  opuCA; glycine betaine/carnitine/choline transport ATP-binding protein OpuCA [KO:K05847] [EC:7.6.2.9]
BSU33730  opuBA; choline transport ATP-binding protein OpuBA [KO:K05847] [EC:7.6.2.9]
BSU38810  msmX; maltodextrin import ATP-binding protein MsmX [KO:K10112]
BSU32550  yurJ; ABC transporter ATP-binding protein [KO:K10112]
BSU34160  cycB; cyclodextrin-binding protein [KO:K15770]
BSU34610  mdxE; maltodextrin-binding protein MdxE [KO:K15770]
BSU34150  ganP; arabinogalactan oligomer transport system permease protein GanP [KO:K15771]
BSU34600  mdxF; maltodextrin transport system permease protein MdxF [KO:K15771]
BSU34140  ganQ; arabinogalactan oligomer transport system permease protein GanQ [KO:K15772]
BSU34590  mdxG; maltodextrin transport system permease protein MdxG [KO:K15772]
BSU30270  msmE; sugar ABC transporter substrate-binding protein [KO:K10117]
BSU32600  frlO; ABC transporter substrate-binding protein YurO [KO:K10117]
BSU30280  amyD; ABC transporter permease [KO:K10118]
BSU32590  frlN; ABC transporter permease [KO:K10118]
BSU32580  frlM; ABC transporter permease [KO:K10119]
BSU30290  amyC; ABC transporter permease [KO:K10119]
BSU07100  lplA; lipoprotein [KO:K17318]
BSU30160  ytcQ; peptide ABC transporter substrate-binding protein [KO:K17318]
BSU07110  lplB; ABC transporter permease LplB [KO:K17319]
BSU30135  yteP; multiple-sugar transport system permease YteP [KO:K17319]
BSU07120  lplC; ABC transporter permease LplC [KO:K17320]
BSU30170  ytcP; ABC transporter permease [KO:K17320]
BSU28750  araN; arabinose-binding protein [KO:K17234]
BSU28740  araP; L-arabinose transport system permease protein AraP [KO:K17235]
BSU28730  araQ; L-arabinose transport system permease protein AraQ [KO:K17236]
BSU31540  yufN; lipoprotein [KO:K07335]
BSU31560  yufP; ABC transporter permease [KO:K23535]
BSU31570  yufQ; ABC transporter permease [KO:K23536]
BSU31550  yufO; ABC transporter ATP-binding protein [KO:K23537]
BSU35960  rbsB; D-ribose-binding protein [KO:K10439]
BSU35950  rbsC; ribose transport system permease RbsC [KO:K10440]
BSU35940  rbsA; ribose import ATP-binding protein RbsA [KO:K10441] [EC:7.5.2.7]
BSU35930  rbsD; D-ribose pyranase [KO:K06726] [EC:5.4.99.62]
BSU24990  pstS; phosphate-binding protein PstS [KO:K02040]
BSU24980  pstC; ABC transporter permease [KO:K02037]
BSU24970  pstA; ABC transporter permease [KO:K02038]
BSU24960  pstBA; phosphate import ATP-binding protein PstB 2 [KO:K02036] [EC:7.3.2.1]
BSU24950  pstBB; phosphate import ATP-binding protein PstB 1 [KO:K02036] [EC:7.3.2.1]
BSU27440  glnH; ABC transporter substrate-binding protein GlnH [KO:K10039]
BSU27450  glnM; glutamine ABC transporter permease protein GlnM [KO:K10040]
BSU27460  glnP; glutamine ABC transporter permease protein GlnP [KO:K10040]
BSU27430  glnQ; glutamine transport ATP-binding protein GlnQ [KO:K10041] [EC:7.4.2.1]
BSU03610  tcyA; L-cystine-binding protein TcyA [KO:K02424]
BSU03380  yckB; ABC transporter substrate-binding protein [KO:K02424]
BSU03600  tcyB; L-cystine transport system permease protein TcyB [KO:K10009]
BSU03370  yckA; amino acid ABC transporter permease protein YckA [KO:K10009]
BSU03590  tcyC; L-cystine import ATP-binding protein TcyC [KO:K10010] [EC:7.4.2.1]
BSU29380  tcyJ; L-cystine-binding protein TcyJ [KO:K16956]
BSU29370  tcyK; L-cystine-binding protein TcyK [KO:K16957]
BSU29360  tcyL; L-cystine transport system permease protein TcyL [KO:K16958]
BSU29350  tcyM; L-cystine transport system permease protein TcyM [KO:K16959]
BSU29340  tcyN; L-cystine import ATP-binding protein TcyN [KO:K16960] [EC:7.4.2.1]
BSU39500  yxeM; amino acid-binding protein YxeM [KO:K16961]
BSU39490  yxeN; amino acid permease protein YxeN [KO:K16962]
BSU39480  yxeO; amino acid import ATP-binding protein YxeO [KO:K16963]
BSU23980  artP; arginine-binding extracellular protein ArtP [KO:K23059]
BSU23970  artQ; arginine transport system permease protein ArtQ [KO:K17077]
BSU23960  artR; arginine transport ATP-binding protein ArtM [KO:K23060] [EC:7.4.2.1]
BSU32730  metN; methionine-binding lipoprotein MetQ [KO:K02073]
BSU09110  yhcJ; lipoprotein [KO:K02073]
BSU32740  metP; methionine import system permease protein MetP [KO:K02072]
BSU32750  metQ; methionine import ATP-binding protein MetN [KO:K02071]
BSU11430  oppA; oligopeptide ABC transporter binding lipoprotein [KO:K15580]
BSU11440  oppB; oligopeptide transport system permease protein OppB [KO:K15581]
BSU11450  oppC; oligopeptide transport system permease protein OppC [KO:K15582]
BSU11460  oppD; oligopeptide transport ATP-binding protein OppD [KO:K15583]
BSU11470  oppF; oligopeptide transport ATP-binding protein OppF [KO:K10823]
BSU12960  dppE; dipeptide ABC transporter substrate-binding protein [KO:K16199]
BSU12930  dppB; dipeptide transport system permease protein DppB [KO:K16200]
BSU12940  dppC; dipeptide transport system permease protein DppC [KO:K16201]
BSU12950  dppD; dipeptide transport ATP-binding protein DppD [KO:K16202]
BSU07520  yfmC; Fe(3+)-citrate-binding protein YfmC [KO:K23181]
BSU07500  yfmE; Fe(3+)-citrate import system permease protein YfmE [KO:K23182]
BSU07510  yfmD; Fe(3+)-citrate import system permease protein YfmD [KO:K23183]
BSU07490  yfmF; Fe(3+)-citrate import ATP-binding protein YfmF [KO:K23184] [EC:7.2.2.18]
BSU26830  yrpE; zinc-binding protein [KO:K09815]
BSU02850  adcA; zinc transport system zinc-binding lipoprotein AdcA [KO:K09815]
BSU02870  adcB; zinc transport system permease protein AdcB [KO:K09816]
BSU02860  adcC; zinc transport system ATP-binding protein AdcC [KO:K09817] [EC:7.2.2.20]
BSU30770  mntA; manganese-binding lipoprotein MntA [KO:K11707]
BSU30750  mntC; manganese transport system membrane protein MntC [KO:K11708]
BSU30740  mntD; manganese transport system membrane protein MntD [KO:K11709]
BSU30760  mntB; manganese transport system ATP-binding protein MntB [KO:K11710] [EC:7.2.2.5]
BSU10370  bioY; biotin transporter BioY [KO:K03523]
BSU32030  bioYB; biotin transporter BioYB [KO:K03523]
BSU01470  ybaF; energy-coupling factor transporter transmembrane protein EcfT [KO:K16785]
BSU13210  thiX; HMP/thiamine permease protein YkoC [KO:K16785]
BSU01450  cbiO; energy-coupling factor transporter ATP-binding protein EcfA1 [KO:K16786] [EC:3.6.3.-]
BSU01460  cbiO; energy-coupling factor transporter ATP-binding protein EcfA2 [KO:K16787] [EC:3.6.3.-]
BSU35710  tagG; teichoic acid translocation permease protein TagG [KO:K09692]
BSU35700  tagH; teichoic acids export ATP-binding protein TagH [KO:K09693] [EC:7.5.2.4]
BSU02760  natB; sodium efflux ABC transporter permease NatB [KO:K09696]
BSU02750  natA; ABC transporter ATP-binding protein [KO:K09697] [EC:7.2.2.4]
BSU30370  bceB; bacitracin export permease protein BceB [KO:K11632]
BSU30380  bceA; bacitracin export ATP-binding protein BceA [KO:K11631]
BSU40140  yydJ; peptide export permease protein YydJ [KO:K16916]
BSU40150  yydI; peptide export ATP-binding protein YydI [KO:K16917]
BSU35250  ftsX; cell division protein FtsX [KO:K09811]
BSU35260  ftsE; cell division ATP-binding protein FtsE [KO:K09812]
BSU30410  ytrF; ABC transporter permease [KO:K16918]
BSU30440  ytrC; ABC transporter permease [KO:K16919]
BSU30430  ytrD; ABC transporter permease [KO:K16919]
BSU30450  ytrB; ABC transporter ATP-binding protein [KO:K16921]
BSU30420  ytrE; ABC transporter ATP-binding protein [KO:K16920]
BSU08690  ygaD; ABC transporter ATP-binding protein [KO:K11085] [EC:3.6.3.-]
BSU09710  yheI; multidrug resistance ABC transporter ATP-binding/permease protein YheI [KO:K18889]
BSU09720  yheH; multidrug resistance ABC transporter ATP-binding/permease protein YheH [KO:K18890]
BSU34820  bmrA; multidrug resistance ABC transporter ATP-binding/permease protein BmrA [KO:K18104] [EC:7.6.2.2]
BSU38730  cydD; ATP-binding/permease protein CydD [KO:K16012]
BSU38740  cydC; ATP-binding/permease protein CydC [KO:K16013]
BSU05610  vmlR; nucleotide-binding protein ExpZ [KO:K18231]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00753  Tungsten
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  D-Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   

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