KEGG   PATHWAY: cal03018Help
cal03018                    Pathway                                

RNA degradation - Candida albicans
The correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay exist and both pathways are initiated by poly(A) shortening of the mRNA. In the 5' to 3' pathway, this is followed by decapping which then permits the 5' to 3' exonucleolytic degradation of transcripts. In the 3' to 5' pathway, the exosome, a large multisubunit complex, plays a key role. The exosome exists in archaeal cells, too. In bacteria, endoribonuclease E, a key enzyme involved in RNA decay and processing, organizes a protein complex called degradosome. RNase E or R interacts with the phosphate-dependent exoribonuclease polynucleotide phosphorylase, DEAD-box helicases, and additional factors in the RNA-degrading complex.
Genetic Information Processing; Folding, sorting and degradation
BRITE hierarchy
Pathway map
cal03018  RNA degradation

Ortholog table
Other DBs
GO: 0006401
Candida albicans [GN:cal]
CAALFM_C701190WA  CaO19.6901; 5'-(N(7)-methyl 5'-triphosphoguanosine)-(mRNA) diphosphatase [KO:K12584] [EC:]
CAALFM_C103830CA  CaO19.1026; exosome non-catalytic core subunit [KO:K07573]
CAALFM_C403740WA  CaO19.1304; exosome non-catalytic core subunit [KO:K03679]
CAALFM_C101160CA  CaO19.3304; exosome non-catalytic core subunit [KO:K03681]
CAALFM_C106540CA  CaO19.6259; exosome non-catalytic core subunit [KO:K12586]
CAALFM_CR02550CA  CaO19.168; exosome non-catalytic core subunit [KO:K12587]
CAALFM_C403840CA  RRP42; exosome non-catalytic core subunit [KO:K12589]
CAALFM_C402090CA  CaO19.4582; exosome non-catalytic core subunit [KO:K11600]
CAALFM_C206660WA  CaO19.81; exosome non-catalytic core subunit [KO:K12590]
CAALFM_C209160WA  CaO19.4078; exosome non-catalytic core subunit [KO:K03678]
CAALFM_C112350WA  CaO19.5229; exosome catalytic subunit [KO:K12585] [EC:3.1.13.-]
CAALFM_C105050CA  RRP6; exosome nuclease subunit [KO:K12591] [EC:3.1.13.-]
CAALFM_C107960WA  CaO19.5067; hypothetical protein [KO:K12592]
CAALFM_CR00810WA  CaO19.3275; hypothetical protein [KO:K12594]
CAALFM_C105360CA  CaO19.429; non-canonical poly(A) polymerase [KO:K03514] [EC:]
CAALFM_C109790CA  CaO19.4844; TRAMP complex RNA-binding subunit [KO:K12597]
CAALFM_C703400CA  CaO19.1335; ATP-dependent RNA helicase [KO:K12598] [EC:]
CAALFM_CR08570WA  SKI2; SKI complex RNA helicase subunit [KO:K12599] [EC:3.6.4.-]
CAALFM_C109830WA  SKI3; SKI complex subunit tetratricopeptide repeat protein [KO:K12600]
CAALFM_C603890CA  SKI8; SKI complex subunit WD repeat protein [KO:K12601]
CAALFM_C108220WA  CCR4; CCR4-NOT core exoribonuclease subunit [KO:K12603] [EC:]
CAALFM_C604270WA  CDC39; CCR4-NOT core subunit [KO:K12604]
CAALFM_C100330CA  CaO19.6075; CCR4-NOT core subunit [KO:K12605]
CAALFM_C108300WA  NOT5; CCR4-NOT core subunit [KO:K12580]
CAALFM_C201130WA  NOT3; CCR4-NOT core subunit [KO:K12580]
CAALFM_CR03420CA  NOT4; CCR4-NOT core ubiquitin-protein ligase subunit [KO:K10643] [EC:]
CAALFM_C603650CA  POP2; CCR4-NOT core DEDD family RNase subunit [KO:K12581]
CAALFM_C703840WA  CaO19.7198; CCR4-NOT core subunit [KO:K12606]
CAALFM_C108430WA  CAF16; putative ATP-binding cassette family ATPase [KO:K12608]
CAALFM_C111930WA  CaO19.5274; hypothetical protein [KO:K12609]
CAALFM_C103370WA  CaO19.3037; polyadenylate-binding protein [KO:K13126]
CAALFM_C109070WA  CaO19.4764; poly(A)-specific ribonuclease [KO:K12571] [EC:]
CAALFM_C505170WA  PAN3; Pan3p [KO:K12572]
CAALFM_C105420WA  CaO19.423; hypothetical protein [KO:K12612]
CAALFM_CR08120CA  DCP2; decapping enzyme complex catalytic subunit [KO:K12613] [EC:]
CAALFM_C107070CA  DHH1; DExD/H-box ATP-dependent RNA helicase [KO:K12614] [EC:]
CAALFM_C405190CA  EDC3; Edc3p [KO:K12615]
CAALFM_C404870CA  CaO19.3792; hypothetical protein [KO:K12617]
CAALFM_C113420CA  KEM1; chromatin-binding exonuclease [KO:K12618] [EC:3.1.13.-]
CAALFM_C401080WA  RAT1; ssRNA exonuclease [KO:K12619] [EC:3.1.13.-]
CAALFM_CR08930CA  CaO19.7290; hypothetical protein [KO:K12620]
CAALFM_CR04260WA  SNP3; Sm-like protein [KO:K12621]
CAALFM_CR07330WA  SMX4; U4/U6-U5 snRNP complex subunit [KO:K12622]
CAALFM_C702510WA  U6 snRNA complex subunit [KO:K12623]
CAALFM_C114410WA  CaO19.7256; RNA-binding protein [KO:K12624]
CAALFM_CR00240WA  LSM6; U4/U6-U5 snRNP complex subunit [KO:K12625]
CAALFM_C503400CA  Sm-like protein [KO:K12626]
CAALFM_C502810WA  U4/U6-U5 snRNP complex subunit [KO:K12627]
CAALFM_C108500CA  ENO1; phosphopyruvate hydratase [KO:K01689] [EC:]
CAALFM_C504810WA  PFK1; 6-phosphofructokinase subunit alpha [KO:K00850] [EC:]
CAALFM_C701800CA  PFK2; 6-phosphofructokinase subunit beta [KO:K00850] [EC:]
CAALFM_C207380WA  SSC1; Hsp70 family ATPase [KO:K04043]
CAALFM_C704010WA  CaO19.7179; Hsp70 family ATPase [KO:K04043]
CAALFM_CR06490CA  HSP60; chaperone ATPase [KO:K04077]
Houseley J, Tollervey D
The many pathways of RNA degradation.
Cell 136:763-76 (2009)
Buttner K, Wenig K, Hopfner KP
The exosome: a macromolecular cage for controlled RNA degradation.
Mol Microbiol 61:1372-9 (2006)
Schilders G, van Dijk E, Raijmakers R, Pruijn GJ
Cell and molecular biology of the exosome: how to make or break an RNA.
Int Rev Cytol 251:159-208 (2006)
Hartung S, Hopfner KP
The exosome, plugged.
EMBO Rep 8:456-7 (2007)
Carpousis AJ
The RNA degradosome of Escherichia coli: an mRNA-degrading machine assembled on RNase E.
Annu Rev Microbiol 61:71-87 (2007)
Marcaida MJ, DePristo MA, Chandran V, Carpousis AJ, Luisi BF
The RNA degradosome: life in the fast lane of adaptive molecular evolution.
Trends Biochem Sci 31:359-65 (2006)
Condon C
Maturation and degradation of RNA in bacteria.
Curr Opin Microbiol 10:271-8 (2007)
KO pathway

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