KEGG Orthology (KO) - Homo sapiens (human)

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     KO
 09100 Metabolism
 
 09120 Genetic Information Processing
 
 09130 Environmental Information Processing
 
   09131 Membrane transport
 
   09132 Signal transduction
     02020 Two-component system
     04010 MAPK signaling pathway [PATH:hsa04010]
     04013 MAPK signaling pathway - fly
     04016 MAPK signaling pathway - plant
     04011 MAPK signaling pathway - yeast
     04012 ErbB signaling pathway [PATH:hsa04012]
     04014 Ras signaling pathway [PATH:hsa04014]
     04015 Rap1 signaling pathway [PATH:hsa04015]
     04310 Wnt signaling pathway [PATH:hsa04310]
     04330 Notch signaling pathway [PATH:hsa04330]
     04340 Hedgehog signaling pathway [PATH:hsa04340]
     04341 Hedgehog signaling pathway - fly
     04350 TGF-beta signaling pathway [PATH:hsa04350]
     04390 Hippo signaling pathway [PATH:hsa04390]
     04391 Hippo signaling pathway - fly
     04392 Hippo signaling pathway - multiple species [PATH:hsa04392]
     04370 VEGF signaling pathway [PATH:hsa04370]
     04371 Apelin signaling pathway [PATH:hsa04371]
     04630 JAK-STAT signaling pathway [PATH:hsa04630]
     04064 NF-kappa B signaling pathway [PATH:hsa04064]
     04668 TNF signaling pathway [PATH:hsa04668]
     04066 HIF-1 signaling pathway [PATH:hsa04066]
     04068 FoxO signaling pathway [PATH:hsa04068]
     04020 Calcium signaling pathway [PATH:hsa04020]
     04070 Phosphatidylinositol signaling system [PATH:hsa04070]
     04072 Phospholipase D signaling pathway [PATH:hsa04072]
     04071 Sphingolipid signaling pathway [PATH:hsa04071]
     04024 cAMP signaling pathway [PATH:hsa04024]
     04022 cGMP-PKG signaling pathway [PATH:hsa04022]
     04151 PI3K-Akt signaling pathway [PATH:hsa04151]
     04152 AMPK signaling pathway [PATH:hsa04152]
     04150 mTOR signaling pathway [PATH:hsa04150]
       8140 SLC7A5; solute carrier family 7 member 5
       6520 SLC3A2; solute carrier family 3 member 2
       153129 SLC38A9; solute carrier family 38 member 9
       523 ATP6V1A; ATPase H+ transporting V1 subunit A
       525 ATP6V1B1; ATPase H+ transporting V1 subunit B1
       526 ATP6V1B2; ATPase H+ transporting V1 subunit B2
       245973 ATP6V1C2; ATPase H+ transporting V1 subunit C2
       528 ATP6V1C1; ATPase H+ transporting V1 subunit C1
       51382 ATP6V1D; ATPase H+ transporting V1 subunit D
       90423 ATP6V1E2; ATPase H+ transporting V1 subunit E2
       529 ATP6V1E1; ATPase H+ transporting V1 subunit E1
       9296 ATP6V1F; ATPase H+ transporting V1 subunit F
       101927180 ATP6V1FP2; V-type proton ATPase subunit F-like
       9550 ATP6V1G1; ATPase H+ transporting V1 subunit G1
       127124 ATP6V1G3; ATPase H+ transporting V1 subunit G3
       534 ATP6V1G2; ATPase H+ transporting V1 subunit G2
       51606 ATP6V1H; ATPase H+ transporting V1 subunit H
       55004 LAMTOR1; late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
       28956 LAMTOR2; late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
       8649 LAMTOR3; late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
       389541 LAMTOR4; late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
       10542 LAMTOR5; late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
       201163 FLCN; folliculin
       96459 FNIP1; folliculin interacting protein 1
       57600 FNIP2; folliculin interacting protein 2
       10670 RRAGA; Ras related GTP binding A
       10325 RRAGB; Ras related GTP binding B
       64121 RRAGC; Ras related GTP binding C
       58528 RRAGD; Ras related GTP binding D
       83667 SESN2; sestrin 2
       652968 CASTOR1; cytosolic arginine sensor for mTORC1 subunit 1
       729438 CASTOR2; cytosolic arginine sensor for mTORC1 subunit 2
       54468 MIOS; meiosis regulator for oocyte development
       81929 SEH1L; SEH1 like nucleoporin
       84219 WDR24; WD repeat domain 24
       79726 WDR59; WD repeat domain 59
       6396 SEC13; SEC13 homolog, nuclear pore and COPII coat complex component
       9681 DEPDC5; DEP domain containing 5, GATOR1 subcomplex subunit
       10641 NPRL2; NPR2 like, GATOR1 complex subunit
       8131 NPRL3; NPR3 like, GATOR1 complex subunit
       6502 SKP2; S-phase kinase associated protein 2
       220441 RNF152; ring finger protein 152
       57521 RPTOR; regulatory associated protein of MTOR complex 1
       84335 AKT1S1; AKT1 substrate 1
       2475 MTOR; mechanistic target of rapamycin kinase
       64798 DEPTOR; DEP domain containing MTOR interacting protein
       64223 MLST8; MTOR associated protein, LST8 homolog
       9894 TELO2; telomere maintenance 2
       9675 TTI1; TELO2 interacting protein 1
       6249 CLIP1; CAP-Gly domain containing linker protein 1
       2887 GRB10; growth factor receptor bound protein 10
       23175 LPIN1; lipin 1
       64900 LPIN3; lipin 3
       9663 LPIN2; lipin 2
       8408 ULK1; unc-51 like autophagy activating kinase 1
       9706 ULK2; unc-51 like autophagy activating kinase 2
       1978 EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
       1977 EIF4E; eukaryotic translation initiation factor 4E
       9470 EIF4E2; eukaryotic translation initiation factor 4E family member 2
       253314 EIF4E1B; eukaryotic translation initiation factor 4E family member 1B
       6198 RPS6KB1; ribosomal protein S6 kinase B1
       6199 RPS6KB2; ribosomal protein S6 kinase B2
       1975 EIF4B; eukaryotic translation initiation factor 4B
       6194 RPS6; ribosomal protein S6
       92335 STRADA; STE20 related adaptor alpha
       55437 STRADB; STE20 related adaptor beta
       6794 STK11; serine/threonine kinase 11
       51719 CAB39; calcium binding protein 39
       81617 CAB39L; calcium binding protein 39 like
       5562 PRKAA1; protein kinase AMP-activated catalytic subunit alpha 1
       5563 PRKAA2; protein kinase AMP-activated catalytic subunit alpha 2
       7248 TSC1; TSC complex subunit 1
       7249 TSC2; TSC complex subunit 2
       51256 TBC1D7; TBC1 domain family member 7
       107080638 TBC1D7-LOC100130357 readthrough
       6009 RHEB; Ras homolog, mTORC1 binding
       54541 DDIT4; DNA damage inducible transcript 4
       7471 WNT1; Wnt family member 1
       7472 WNT2; Wnt family member 2
       7482 WNT2B; Wnt family member 2B
       7473 WNT3; Wnt family member 3
       89780 WNT3A; Wnt family member 3A
       54361 WNT4; Wnt family member 4
       7474 WNT5A; Wnt family member 5A
       81029 WNT5B; Wnt family member 5B
       7475 WNT6; Wnt family member 6
       7476 WNT7A; Wnt family member 7A
       7477 WNT7B; Wnt family member 7B
       7478 WNT8A; Wnt family member 8A
       7479 WNT8B; Wnt family member 8B
       7483 WNT9A; Wnt family member 9A
       7484 WNT9B; Wnt family member 9B
       7480 WNT10B; Wnt family member 10B
       80326 WNT10A; Wnt family member 10A
       7481 WNT11; Wnt family member 11
       51384 WNT16; Wnt family member 16
       8321 FZD1; frizzled class receptor 1
       8324 FZD7; frizzled class receptor 7
       2535 FZD2; frizzled class receptor 2
       7976 FZD3; frizzled class receptor 3
       8322 FZD4; frizzled class receptor 4
       7855 FZD5; frizzled class receptor 5
       8325 FZD8; frizzled class receptor 8
       8323 FZD6; frizzled class receptor 6
       11211 FZD10; frizzled class receptor 10
       8326 FZD9; frizzled class receptor 9
       4041 LRP5; LDL receptor related protein 5
       4040 LRP6; LDL receptor related protein 6
       1857 DVL3; dishevelled segment polarity protein 3
       1856 DVL2; dishevelled segment polarity protein 2
       1855 DVL1; dishevelled segment polarity protein 1
       2932 GSK3B; glycogen synthase kinase 3 beta
       7124 TNF; tumor necrosis factor
       7132 TNFRSF1A; TNF receptor superfamily member 1A
       3551 IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
       3630 INS; insulin
       3479 IGF1; insulin like growth factor 1
       3643 INSR; insulin receptor
       3480 IGF1R; insulin like growth factor 1 receptor
       2885 GRB2; growth factor receptor bound protein 2
       6654 SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1
       6655 SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2
       3265 HRAS; HRas proto-oncogene, GTPase
       3845 KRAS; KRAS proto-oncogene, GTPase
       4893 NRAS; NRAS proto-oncogene, GTPase
       673 BRAF; B-Raf proto-oncogene, serine/threonine kinase
       5894 RAF1; Raf-1 proto-oncogene, serine/threonine kinase
       5604 MAP2K1; mitogen-activated protein kinase kinase 1
       5605 MAP2K2; mitogen-activated protein kinase kinase 2
       5594 MAPK1; mitogen-activated protein kinase 1
       5595 MAPK3; mitogen-activated protein kinase 3
       6197 RPS6KA3; ribosomal protein S6 kinase A3
       6195 RPS6KA1; ribosomal protein S6 kinase A1
       6196 RPS6KA2; ribosomal protein S6 kinase A2
       27330 RPS6KA6; ribosomal protein S6 kinase A6
       3667 IRS1; insulin receptor substrate 1
       5295 PIK3R1; phosphoinositide-3-kinase regulatory subunit 1
       5296 PIK3R2; phosphoinositide-3-kinase regulatory subunit 2
       8503 PIK3R3; phosphoinositide-3-kinase regulatory subunit 3
       110117499 P3R3URF-PIK3R3; P3R3URF-PIK3R3 readthrough
       5290 PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
       5293 PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
       5291 PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
       5728 PTEN; phosphatase and tensin homolog
       5170 PDPK1; 3-phosphoinositide dependent protein kinase 1
       207 AKT1; AKT serine/threonine kinase 1
       208 AKT2; AKT serine/threonine kinase 2
       10000 AKT3; AKT serine/threonine kinase 3
       1147 CHUK; component of inhibitor of nuclear factor kappa B kinase complex
       79109 MAPKAP1; MAPK associated protein 1
       253260 RICTOR; RPTOR independent companion of MTOR complex 2
       55615 PRR5; proline rich 5
       79899 PRR5L; proline rich 5 like
       387 RHOA; ras homolog family member A
       5578 PRKCA; protein kinase C alpha
       5579 PRKCB; protein kinase C beta
       5582 PRKCG; protein kinase C gamma
       6446 SGK1; serum/glucocorticoid regulated kinase 1
K13780 SLC7A5; solute carrier family 7 (L-type amino acid transporter), member 5
K06519 SLC3A2; solute carrier family 3, member 2
K14995 SLC38A9; solute carrier family 38 (sodium-coupled neutral amino acid transporter), member 9
K02145 ATPeV1A; V-type H+-transporting ATPase subunit A [EC:7.1.2.2]
K02147 ATPeV1B; V-type H+-transporting ATPase subunit B
K02147 ATPeV1B; V-type H+-transporting ATPase subunit B
K02148 ATPeV1C; V-type H+-transporting ATPase subunit C
K02148 ATPeV1C; V-type H+-transporting ATPase subunit C
K02149 ATPeV1D; V-type H+-transporting ATPase subunit D
K02150 ATPeV1E; V-type H+-transporting ATPase subunit E
K02150 ATPeV1E; V-type H+-transporting ATPase subunit E
K02151 ATPeV1F; V-type H+-transporting ATPase subunit F
K02151 ATPeV1F; V-type H+-transporting ATPase subunit F
K02152 ATPeV1G; V-type H+-transporting ATPase subunit G
K02152 ATPeV1G; V-type H+-transporting ATPase subunit G
K02152 ATPeV1G; V-type H+-transporting ATPase subunit G
K02144 ATPeV1H; V-type H+-transporting ATPase subunit H
K20397 LAMTOR1; ragulator complex protein LAMTOR1
K20398 LAMTOR2; ragulator complex protein LAMTOR2
K04370 LAMTOR3; ragulator complex protein LAMTOR3
K20399 LAMTOR4; ragulator complex protein LAMTOR4
K16344 LAMTOR5; ragulator complex protein LAMTOR5
K09594 FLCN; folliculin
K20400 FNIP1; folliculin-interacting protein 1
K20401 FNIP2; folliculin-interacting protein 2
K16185 RRAGA_B; Ras-related GTP-binding protein A/B
K16185 RRAGA_B; Ras-related GTP-binding protein A/B
K16186 RRAGC_D; Ras-related GTP-binding protein C/D
K16186 RRAGC_D; Ras-related GTP-binding protein C/D
K20394 SESN2; sestrin 2
K23080 CASTOR1; cytosolic arginine sensor for mTORC1 subunit 1
K23081 CASTOR2; cytosolic arginine sensor for mTORC1 subunit 2
K20407 MIOS; SEA/GATOR complex protein SEA4/MIOS
K14299 SEH1; nucleoporin SEH1
K20408 WDR24; SEA/GATOR complex protein SEA2/WDR24
K20409 WDR59; SEA/GATOR complex protein SEA3/WDR59
K14004 SEC13; protein transport protein SEC13
K20404 DEPDC5; SEA/GATOR complex protein SEA1/DEPDC5
K20405 NPRL2; nitrogen permease regulator 2
K20406 NPRL3; nitrogen permease regulator 3
K03875 SKP2; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
K15705 RNF152; E3 ubiquitin-protein ligase RNF152 [EC:2.3.2.27]
K07204 RAPTOR; regulatory associated protein of mTOR
K16184 AKT1S1; proline-rich AKT1 substrate 1
K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
K20402 DEPTOR; DEP domain-containing mTOR-interacting protein
K08266 MLST8; target of rapamycin complex subunit LST8
K11137 TELO2; telomere length regulation protein
K20403 TTI1; TELO2-interacting protein 1
K10421 CLIP1; CAP-Gly domain-containing linker protein 1
K20064 GRB10; growth factor receptor-bound protein 10
K15728 LPIN; phosphatidate phosphatase LPIN [EC:3.1.3.4]
K15728 LPIN; phosphatidate phosphatase LPIN [EC:3.1.3.4]
K15728 LPIN; phosphatidate phosphatase LPIN [EC:3.1.3.4]
K21357 ULK1; serine/threonine-protein kinase ULK1 [EC:2.7.11.1]
K08269 ULK2; serine/threonine-protein kinase ULK2 [EC:2.7.11.1]
K07205 EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
K03259 EIF4E; translation initiation factor 4E
K03259 EIF4E; translation initiation factor 4E
K03259 EIF4E; translation initiation factor 4E
K04688 RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]
K04688 RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]
K03258 EIF4B; translation initiation factor 4B
K02991 RP-S6e; small subunit ribosomal protein S6e
K08271 STRADA; STE20-related kinase adapter protein alpha
K17532 STRADB; STE20-related kinase adapter protein beta
K07298 STK11; serine/threonine-protein kinase 11 [EC:2.7.11.1]
K08272 CAB39; calcium binding protein 39
K08272 CAB39; calcium binding protein 39
K07198 PRKAA; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31]
K07198 PRKAA; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31]
K07206 TSC1; tuberous sclerosis 1
K07207 TSC2; tuberous sclerosis 2
K20396 TBC1D7; TBC1 domain family member 7
K20396 TBC1D7; TBC1 domain family member 7
K07208 RHEB; Ras homolog enriched in brain
K08270 DDIT4; DNA-damage-inducible transcript 4
K03209 WNT1; wingless-type MMTV integration site family, member 1
K00182 WNT2; wingless-type MMTV integration site family, member 2
K00182 WNT2; wingless-type MMTV integration site family, member 2
K00312 WNT3; wingless-type MMTV integration site family, member 3
K00312 WNT3; wingless-type MMTV integration site family, member 3
K00408 WNT4; wingless-type MMTV integration site family, member 4
K00444 WNT5; wingless-type MMTV integration site family, member 5
K00444 WNT5; wingless-type MMTV integration site family, member 5
K00445 WNT6; wingless-type MMTV integration site family, member 6
K00572 WNT7; wingless-type MMTV integration site family, member 7
K00572 WNT7; wingless-type MMTV integration site family, member 7
K00714 WNT8; wingless-type MMTV integration site family, member 8
K00714 WNT8; wingless-type MMTV integration site family, member 8
K01064 WNT9; wingless-type MMTV integration site family, member 9
K01064 WNT9; wingless-type MMTV integration site family, member 9
K01357 WNT10; wingless-type MMTV integration site family, member 10
K01357 WNT10; wingless-type MMTV integration site family, member 10
K01384 WNT11; wingless-type MMTV integration site family, member 11
K01558 WNT16; wingless-type MMTV integration site family, member 16
K02432 FZD1_7; frizzled 1/7
K02432 FZD1_7; frizzled 1/7
K02235 FZD2; frizzled 2
K02329 FZD3; frizzled 3
K02354 FZD4; frizzled 4
K02375 FZD5_8; frizzled 5/8
K02375 FZD5_8; frizzled 5/8
K02376 FZD6; frizzled 6
K02842 FZD9_10; frizzled 9/10
K02842 FZD9_10; frizzled 9/10
K03068 LRP5_6; low density lipoprotein receptor-related protein 5/6
K03068 LRP5_6; low density lipoprotein receptor-related protein 5/6
K02353 DVL; segment polarity protein dishevelled
K02353 DVL; segment polarity protein dishevelled
K02353 DVL; segment polarity protein dishevelled
K03083 GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
K03156 TNF; tumor necrosis factor superfamily, member 2
K03158 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A
K07209 IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K04526 INS; insulin
K05459 IGF1; insulin-like growth factor 1
K04527 INSR; insulin receptor [EC:2.7.10.1]
K05087 IGF1R; insulin-like growth factor 1 receptor [EC:2.7.10.1]
K04364 GRB2; growth factor receptor-bound protein 2
K03099 SOS; son of sevenless
K03099 SOS; son of sevenless
K02833 HRAS; GTPase HRas
K07827 KRAS; GTPase KRas
K07828 NRAS; GTPase NRas
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04366 RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04373 RPS6KA; ribosomal protein S6 kinase alpha-1/2/3/6 [EC:2.7.11.1]
K04373 RPS6KA; ribosomal protein S6 kinase alpha-1/2/3/6 [EC:2.7.11.1]
K04373 RPS6KA; ribosomal protein S6 kinase alpha-1/2/3/6 [EC:2.7.11.1]
K04373 RPS6KA; ribosomal protein S6 kinase alpha-1/2/3/6 [EC:2.7.11.1]
K16172 IRS1; insulin receptor substrate 1
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K01110 PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
K06276 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04467 IKBKA; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K20410 MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1/AVO1
K08267 RICTOR; rapamycin-insensitive companion of mTOR
K20411 PRR5; proline-rich protein 5
K20411 PRR5; proline-rich protein 5
K04513 RHOA; Ras homolog gene family, member A
K02677 PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]
K19662 PRKCB; classical protein kinase C beta type [EC:2.7.11.13]
K19663 PRKCG; classical protein kinase C gamma type [EC:2.7.11.13]
K13302 SGK1; serum/glucocorticoid-regulated kinase 1 [EC:2.7.11.1]
     04075 Plant hormone signal transduction
 
   09133 Signaling molecules and interaction
 
 09140 Cellular Processes
 
 09150 Organismal Systems
 
 09160 Human Diseases
 
 09180 Brite Hierarchies
 
 09190 Not Included in Pathway or Brite

[ KO | BRITE | KEGG2 | KEGG ]
Last updated: September 19, 2024