MAPK signaling |
N00001 |
![](/tmp/network_17185685711976553/1_N00001_ds.png) |
EGF | → | EGFR | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK | → | CCND1 |
N00540 |
![](/tmp/network_17185685711976553/2_N00540_ds.png) |
X | → | SRC | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK | → | ELK1 |
N00274 |
![](/tmp/network_17185685711976553/3_N00274_ds.png) |
| | NS5A | ⊣ | GRB2 |
N00518 |
![](/tmp/network_17185685711976553/4_N00518_ds.png) |
| | | | | | Core | ⊣ | YWHA | ⊣ | RAF | → | MEK | → | ERK |
N00519 |
![](/tmp/network_17185685711976553/5_N00519_ds.png) |
| | | | | | | | | | Core | → | MEK |
N00229 |
![](/tmp/network_17185685711976553/6_N00229_ds.png) |
TGFA | → | EGFR | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK |
N00230 |
![](/tmp/network_17185685711976553/7_N00230_ds.png) |
TGFA* | → | EGFR | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK |
N00233 |
![](/tmp/network_17185685711976553/8_N00233_ds.png) |
IGF | → | IGF1R | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK |
N00235 |
![](/tmp/network_17185685711976553/9_N00235_ds.png) |
IGF2* | → | IGF1R | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK |
N00237 |
![](/tmp/network_17185685711976553/10_N00237_ds.png) |
IGF2 | → | IGF1R* | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK |
N00216 |
![](/tmp/network_17185685711976553/11_N00216_ds.png) |
HGF | → | MET | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK |
N00246 |
![](/tmp/network_17185685711976553/12_N00246_ds.png) |
HGF* | → | MET | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK |
N00005 |
![](/tmp/network_17185685711976553/13_N00005_ds.png) |
| | MET* | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK | → | CCND1 |
N00248 |
![](/tmp/network_17185685711976553/14_N00248_ds.png) |
| | MET* | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK |
N00541 |
![](/tmp/network_17185685711976553/15_N00541_ds.png) |
| | | | | | X | → | RAS |
N00545 |
![](/tmp/network_17185685711976553/16_N00545_ds.png) |
| | | | | | | | | | | | X | → | ERK | → | AP1 | ⇒ | MMP9 |
N00542 |
![](/tmp/network_17185685711976553/17_N00542_ds.png) |
EGF | → | EGFR | → | GRB2 | → | SOS | → | RAS | → | MEKK1 | → | MKK4 | → | JNK |
N00543 |
![](/tmp/network_17185685711976553/18_N00543_ds.png) |
| | | | | | | | | | | | X | → | JNK | → | JUN |
N00538 |
![](/tmp/network_17185685711976553/19_N00538_ds.png) |
| | | | Ca2+ | → | PTK2B | → | SRC | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK |
N00539 |
![](/tmp/network_17185685711976553/20_N00539_ds.png) |
X | → | VDAC3 | → | Ca2+ |
PI3K signaling |
N00033 |
![](/tmp/network_17185685711976553/22_N00033_ds.png) |
EGF | → | EGFR | → | PI3K | → | PIP3 | → | AKT | ⊣ | BAD |
N00267 |
![](/tmp/network_17185685711976553/23_N00267_ds.png) |
| | X | → | PI3K |
N00272 |
![](/tmp/network_17185685711976553/24_N00272_ds.png) |
| | NS5A | → | PI3K |
N00049 |
![](/tmp/network_17185685711976553/25_N00049_ds.png) |
| | | | PI3K* | → | PIP3 | → | AKT | → | MTOR | → | S6K |
N00231 |
![](/tmp/network_17185685711976553/26_N00231_ds.png) |
TGFA | → | EGFR | → | PI3K | → | PIP3 | → | AKT | → | MTOR |
N00232 |
![](/tmp/network_17185685711976553/27_N00232_ds.png) |
TGFA* | → | EGFR | → | PI3K | → | PIP3 | → | AKT |
N00234 |
![](/tmp/network_17185685711976553/28_N00234_ds.png) |
IGF2 | → | IGF1R | → | PI3K | → | PIP3 | → | AKT | → | MTOR | → | S6K |
N00238 |
![](/tmp/network_17185685711976553/29_N00238_ds.png) |
IGF2 | → | IGF1R* | → | PI3K | → | PIP3 | → | AKT | → | MTOR | → | S6K |
N00236 |
![](/tmp/network_17185685711976553/30_N00236_ds.png) |
IGF2* | → | IGF1R | → | PI3K | → | PIP3 | → | AKT | → | MTOR | → | S6K |
N00043 |
![](/tmp/network_17185685711976553/31_N00043_ds.png) |
HGF | → | MET | → | GAB1 | → | PI3K | → | PIP3 | → | AKT | ⊣ | BAD |
N00247 |
![](/tmp/network_17185685711976553/32_N00247_ds.png) |
HGF* | → | MET | → | GAB1 | → | PI3K | → | PIP3 | → | AKT | ⊣ | BAD |
N00044 |
![](/tmp/network_17185685711976553/33_N00044_ds.png) |
MET* | → | GAB1 | → | PI3K | → | PIP3 | → | AKT | ⊣ | BAD |
N00249 |
![](/tmp/network_17185685711976553/34_N00249_ds.png) |
MET* | → | GAB1 | → | PI3K | → | PIP3 | → | AKT | ⊣ | BAD |
N00220 |
![](/tmp/network_17185685711976553/35_N00220_ds.png) |
| | | | | | PTEN | ⊣ | PIP3 | → | AKT |
N00052 |
![](/tmp/network_17185685711976553/36_N00052_ds.png) |
| | | | | | PTEN* | ⌿ | PIP3 | → | AKT |
WNT signaling |
N00056 |
![](/tmp/network_17185685711976553/38_N00056_ds.png) |
WNT | → | (FZD+LRP5/6) | → | (DVL+FRAT) | ⊣ | (GSK3B+AXIN+APC) | ⊣ | CTNNB1 | → | TCF/LEF | ⇒ | (MYC,CCND1) |
N00059 |
![](/tmp/network_17185685711976553/39_N00059_ds.png) |
WNT | → | (FZD7*+LRP5/6) | → | (DVL+FRAT) | ⊣ | (GSK3B+AXIN+APC) | ⊣ | CTNNB1 | → | TCF/LEF | ⇒ | (MYC,CCND1) |
N00242 |
![](/tmp/network_17185685711976553/40_N00242_ds.png) |
| | | | (GSK3B+APC) | ⌿ | AXIN* | ⌿ | CTNNB1 | → | TCF/LEF | ⇒ | (MYC,CCND1) |
N00058 |
![](/tmp/network_17185685711976553/41_N00058_ds.png) |
| | | | (GSK3B+AXIN+APC) | ⌿ | CTNNB1* | → | TCF/LEF | ⇒ | (BIRC5,MYC,CCND1) |
TGFB signaling |
N00063 |
![](/tmp/network_17185685711976553/43_N00063_ds.png) |
| | | | TGFB | → | (TGFBR2+TGFBR1) | → | (SMAD2,SMAD3) | = | SMAD4 |
N00531 |
![](/tmp/network_17185685711976553/44_N00531_ds.png) |
| | X | → | TGFB | → | (TGFBR2+TGFBR1) | → | (SMAD2,SMAD3) | = | SMAD4 |
N00241 |
![](/tmp/network_17185685711976553/45_N00241_ds.png) |
| | | | | | (TGFBR2*+TGFBR1) | ⌿ | (SMAD2,SMAD3) |
Calcium signaling |
N00227 |
![](/tmp/network_17185685711976553/47_N00227_ds.png) |
TGFA | → | EGFR | → | PLCG | → | IP3 | → | (Ca2+,DAG) | → | PKC | → | ELK1 |
N00228 |
![](/tmp/network_17185685711976553/48_N00228_ds.png) |
TGFA* | → | EGFR | → | PLCG | → | IP3 | → | (Ca2+,DAG) | → | PKC | → | ELK1 |
JAK-STAT signaling |
N00053 |
![](/tmp/network_17185685711976553/50_N00053_ds.png) |
Cytokine | → | Receptor | → | JAK | → | STAT | ⇒ | PIM1 |
N00548 |
![](/tmp/network_17185685711976553/51_N00548_ds.png) |
| | | | X | → | STAT3 |
TLR signaling |
N00435 |
![](/tmp/network_17185685711976553/53_N00435_ds.png) |
| | (TLR1,TLR2,TLR4) | → | (TIRAP+MYD88) | → | (IRAK4+IRAK1) | → | (TRAF6+TAK1+TAB2) | → | IKK | → | NFKBIA | → | NFKB | ⇒ | (TNF,IL6,IL12A,IL1.. |
N00556 |
![](/tmp/network_17185685711976553/54_N00556_ds.png) |
C | ⊣ | TLR2 |
N00557 |
![](/tmp/network_17185685711976553/55_N00557_ds.png) |
| | C | ⊣ | TIRAP |
N00549 |
![](/tmp/network_17185685711976553/56_N00549_ds.png) |
| | C | ⊣ | MYD88 |
N00550 |
![](/tmp/network_17185685711976553/57_N00550_ds.png) |
| | | | | | | | | | | | C | ⊣ | NFKB |
N00269 |
![](/tmp/network_17185685711976553/58_N00269_ds.png) |
| | | | | | | | Core | → | NFKB |
N00438 |
![](/tmp/network_17185685711976553/59_N00438_ds.png) |
| | (TLR2,TLR4) | → | (TIRAP+MYD88) | → | (IRAK4+IRAK1) | → | (TRAF6+TAK1+TAB2) | → | (MEK,MKK3/6,MKK4/7.. | → | (ERK,p38,JNK) | → | AP1 |
N00551 |
![](/tmp/network_17185685711976553/60_N00551_ds.png) |
| | | | | | | | | | S | ⊣ | JNK |
N00553 |
![](/tmp/network_17185685711976553/61_N00553_ds.png) |
| | TLR4 | → | TICAM2 | → | TICAM1 | → | TRAF3 | → | (IKBKE+TBK1) | → | (IRF3,IRF7) | ⇒ | IFNB1 |
N00554 |
![](/tmp/network_17185685711976553/62_N00554_ds.png) |
| | C | ⊣ | TICAM2 |
N00555 |
![](/tmp/network_17185685711976553/63_N00555_ds.png) |
| | | | C | ⊣ | TICAM1 |
N00149 |
![](/tmp/network_17185685711976553/64_N00149_ds.png) |
| | | | TLR3 | → | TICAM1 | → | TRAF3 | → | (IKBKE+TBK1) | → | IRF3 | → | (CREBBP,EP300) | ⇒ | IFNB1 |
N00516 |
![](/tmp/network_17185685711976553/65_N00516_ds.png) |
| | | | (NS3,NS4A) | ⊣ | TICAM1 |
N00552 |
![](/tmp/network_17185685711976553/66_N00552_ds.png) |
| | | | | | P | ⊣ | DDX3X | = | (IKBKE+TBK1) |
RLR signaling |
N00469 |
![](/tmp/network_17185685711976553/68_N00469_ds.png) |
RNA | → | RIGI | → | MAVS | → | TRAF3 | → | (TANK+NAP1+SINTBAD.. | → | (TBK1+IKBKE) | → | (IRF7,IRF3) | ⇒ | (IFNA,IFNB1) |
N00271 |
![](/tmp/network_17185685711976553/69_N00271_ds.png) |
| | (NS3,NS4A) | ⊣ | MAVS |
N00268 |
![](/tmp/network_17185685711976553/70_N00268_ds.png) |
| | X | ⊣ | MAVS |
NLR signaling |
N00515 |
![](/tmp/network_17185685711976553/72_N00515_ds.png) |
| | OAS | → | 2-5A | → | RNASEL |
N00273 |
![](/tmp/network_17185685711976553/73_N00273_ds.png) |
NS5A | ⊣ | OAS |
IFN signaling |
N00150 |
![](/tmp/network_17185685711976553/75_N00150_ds.png) |
(IFNA,IFNB1) | → | (IFNAR1+IFNAR2) | → | (JAK1,TYK2) | → | (STAT1+STAT2+IRF9) | ⇒ | (IRF7,EIF2AK2) |
N00270 |
![](/tmp/network_17185685711976553/76_N00270_ds.png) |
| | | | Core | ⊣ | (STAT1+STAT2+IRF9) |
N00558 |
![](/tmp/network_17185685711976553/77_N00558_ds.png) |
| | | | P | ⊣ | (STAT1+STAT2) |
TNF signaling |
N00151 |
![](/tmp/network_17185685711976553/79_N00151_ds.png) |
TNF | → | TNFRSF1A | → | (RIPK1+TRADD+TRAF2.. | → | (TAB1/2/3+TAK1) | → | IKK | → | NFKBIA | → | NFKB |
N00525 |
![](/tmp/network_17185685711976553/80_N00525_ds.png) |
| | NS5A | ⊣ | (TRADD+TRAF2) |
N00269 |
![](/tmp/network_17185685711976553/81_N00269_ds.png) |
| | | | | | | | Core | → | NFKB |
N00145 |
![](/tmp/network_17185685711976553/82_N00145_ds.png) |
TNF | → | TNFRSF1A | → | (RIPK1+TRADD+TRAF2.. | → | FADD | → | CASP8 | → | (CASP3,CASP7) |
N00524 |
![](/tmp/network_17185685711976553/83_N00524_ds.png) |
| | NS5A | ⊣ | TRADD |
N00528 |
![](/tmp/network_17185685711976553/84_N00528_ds.png) |
| | | | Core | → | CFLAR | ⊣ | CASP8 |
Chemokine signaling |
N00546 |
![](/tmp/network_17185685711976553/86_N00546_ds.png) |
CXCL12 | → | CXCR4 | → | GNAQ | → | (PLCB,PLCG) | → | IP3 | → | Ca2+ | → | PKC | → | RAF | → | MEK | → | ERK |
N00547 |
![](/tmp/network_17185685711976553/87_N00547_ds.png) |
| | | | | | | | | | S | → | PKC |
KEAP1-NRF2 signaling |
N00243 |
![](/tmp/network_17185685711976553/89_N00243_ds.png) |
(O2-,HO2,H2O2,OH,A.. | ⊣ | KEAP1 | ⊣ | NRF2 | ⇒ | (HMOX1,NQO1,GST,TX.. |
N00244 |
![](/tmp/network_17185685711976553/90_N00244_ds.png) |
| | KEAP1* | ⌿ | NRF2 | ⇒ | (HMOX1,NQO1,GST,TX.. |
N00245 |
![](/tmp/network_17185685711976553/91_N00245_ds.png) |
| | KEAP1 | ⌿ | NRF2* | ⇒ | (HMOX1,NQO1,GST,TX.. |
Cell cycle |
N00066 |
![](/tmp/network_17185685711976553/93_N00066_ds.png) |
CDKN2A | ⊣ | MDM2 | ⊣ | TP53 | ⇒ | CDKN1A | ⊣ | (CCND+CDK4/6) | → | RB1 | ⌿ | E2F |
N00521 |
![](/tmp/network_17185685711976553/94_N00521_ds.png) |
| | Core | ⊣ | TP53 |
N00520 |
![](/tmp/network_17185685711976553/95_N00520_ds.png) |
| | NS5A | ⊣ | TP53 |
N00522 |
![](/tmp/network_17185685711976553/96_N00522_ds.png) |
| | NS3 | ⊣ | TP53 |
N00523 |
![](/tmp/network_17185685711976553/97_N00523_ds.png) |
| | | | Core | ⊣ | CDKN1A |
N00071 |
![](/tmp/network_17185685711976553/98_N00071_ds.png) |
| | | | | | CDKN2A* | ⌿ | (CCND+CDK4/6) | → | RB1 | ⌿ | E2F |
N00074 |
![](/tmp/network_17185685711976553/99_N00074_ds.png) |
| | | | | | | | | | RB1* | ⌿ | E2F |
N00536 |
![](/tmp/network_17185685711976553/100_N00536_ds.png) |
CDKN2A | ⊣ | MDM2 | ⊣ | TP53 | ⇒ | CDKN1A | ⊣ | (CCNE+CDK2) | → | RB1 | ⌿ | E2F |
N00537 |
![](/tmp/network_17185685711976553/101_N00537_ds.png) |
| | | | | | X | → | (CCNE+CDK2) | → | RB1 | ⌿ | E2F |
Apoptosis |
N00146 |
![](/tmp/network_17185685711976553/103_N00146_ds.png) |
| | (FASLG,TNFSF10) | → | (FAS,TNFRSF10B) | → | FADD | → | (CASP8,CASP10) | → | BID | → | (BAX,BAK1) | → | CYCS | = | APAF1 | → | CASP9 | → | (CASP3,CASP7) |
N00527 |
![](/tmp/network_17185685711976553/104_N00527_ds.png) |
| | Core | → | FAS |
N00526 |
![](/tmp/network_17185685711976553/105_N00526_ds.png) |
| | | | | | NS3 | → | CASP8 |
N00534 |
![](/tmp/network_17185685711976553/106_N00534_ds.png) |
| | | | | | | | | | X | → | BAX |
N00533 |
![](/tmp/network_17185685711976553/107_N00533_ds.png) |
| | | | | | | | | | | | | | X | → | BIRC5 | ⊣ | CASP9 |
Telomerase activity |
N00239 |
![](/tmp/network_17185685711976553/109_N00239_ds.png) |
TERC | ⌿ | DNA |
N00240 |
![](/tmp/network_17185685711976553/110_N00240_ds.png) |
(TERT*+TERC) | → | DNA |
Transcription |
N00115 |
![](/tmp/network_17185685711976553/112_N00115_ds.png) |
| | TP53* | ⌿ | (CDKN1A,GADD45,BAX.. |
N00535 |
![](/tmp/network_17185685711976553/113_N00535_ds.png) |
X | ⊣ | TP53 | ⇒ | (CDKN1A,BAX,FAS) |
N00532 |
![](/tmp/network_17185685711976553/114_N00532_ds.png) |
X | → | (EGR2,EGR3) | = | EP300 | ⇒ | FASLG |
N00544 |
![](/tmp/network_17185685711976553/115_N00544_ds.png) |
X | → | CREBBP | = | (CREB+ATF2) | ⇒ | (CXCL8,PCNA) |
N00529 |
![](/tmp/network_17185685711976553/116_N00529_ds.png) |
Core | → | (RXRA+PPARA) | ⇒ | (CCND1,CDK4,MYC) |
N00530 |
![](/tmp/network_17185685711976553/117_N00530_ds.png) |
(Core+PSME3) | → | (RXRA+NR1H3) | ⇒ | (CCND1,CDK4,MYC) |
|