PCIDB

KNApSAcK Metabolite C00001418

Metabolite

KNApSAcK Entry

id C00001418
Name Indole
CAS RN 120-72-9
Standard InChI InChI=1S/C8H7N/c1-2-4-8-7(3-1)5-6-9-8/h1-6,9H
Standard InChI (Main Layer) InChI=1S/C8H7N/c1-2-4-8-7(3-1)5-6-9-8/h1-6,9H

Cluster

Phytochemical cluster
KCF-S cluster No. 3673

Link

ChEMBL

By standard InChI CHEMBL15844
By standard InChI Main Layer CHEMBL15844

KEGG

By LinkDB C00463

CTD

By CAS RN C030374

Human Protein / Gene in interaction

13 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P00918 Carbonic anhydrase 2 Lyase CHEMBL15844 CHEMBL1948547 (1)
1 / 2
Q00535 Cyclin-dependent kinase 5 Cdk5 CHEMBL15844 CHEMBL663613 (1) CHEMBL663614 (1)
0 / 0
Q15078 Cyclin-dependent kinase 5 activator 1 REG serine/threonine protein kinase family CHEMBL15844 CHEMBL663613 (1) CHEMBL663614 (1)
0 / 0
P23280 Carbonic anhydrase 6 Lyase CHEMBL15844 CHEMBL1948549 (1)
0 / 0
P00915 Carbonic anhydrase 1 Lyase CHEMBL15844 CHEMBL1948546 (1)
0 / 0
P55263 Adenosine kinase Enzyme CHEMBL15844 CHEMBL644802 (1) CHEMBL822078 (1)
1 / 0
P23141 Liver carboxylesterase 1 Enzyme CHEMBL15844 CHEMBL918632 (1)
0 / 0
P22748 Carbonic anhydrase 4 Lyase CHEMBL15844 CHEMBL1948548 (1)
1 / 1
P05107 Integrin beta-2 Membrane receptor CHEMBL15844 CHEMBL703097 (1) CHEMBL703266 (1)
1 / 1
P05362 Intercellular adhesion molecule 1 Adhesion CHEMBL15844 CHEMBL703097 (1) CHEMBL703266 (1)
1 / 2
P20701 Integrin alpha-L Membrane receptor CHEMBL15844 CHEMBL703097 (1) CHEMBL703266 (1)
0 / 0
P49840 Glycogen synthase kinase-3 alpha Gsk CHEMBL15844 CHEMBL683011 (1) CHEMBL683012 (1)
0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk CHEMBL15844 CHEMBL683011 (1) CHEMBL683012 (1)
0 / 0

CTD interaction (6)

compound gene gene name gene description interaction interaction type form reference
pmid
C030374 196 AHR
bHLHe76
aryl hydrocarbon receptor indole results in increased activity of [AHR protein binds to ARNT protein] affects binding
/ increases activity
protein 9407059
C030374 405 ARNT
HIF-1-beta
HIF-1beta
HIF1-beta
HIF1B
HIF1BETA
TANGO
bHLHe2
aryl hydrocarbon receptor nuclear translocator indole results in increased activity of [AHR protein binds to ARNT protein] affects binding
/ increases activity
protein 9407059
C030374 4157 MC1R
CMM5
MSH-R
SHEP2
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) indole analog binds to MC1R protein affects binding
protein 11909711
C030374 4159 MC3R
BMIQ9
MC3
MC3-R
OB20
OQTL
melanocortin 3 receptor indole analog binds to MC3R protein affects binding
protein 11909711
C030374 4160 MC4R
melanocortin 4 receptor indole analog binds to MC4R protein affects binding
protein 11909711
C030374 4161 MC5R
MC2
melanocortin 5 receptor indole analog binds to MC5R protein affects binding
protein 11909711

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (5)

OMIM preferred title UniProt
#614300 Hypermethioninemia due to adenosine kinase deficiency P55263
#116920 Leukocyte adhesion deficiency, type i; lad P05107
#611162 Malaria, susceptibility to P05362
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#600852 Retinitis pigmentosa 17; rp17 P22748

KEGG DISEASE (6)

KEGG disease name UniProt
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00099 Leukocyte adhesion deficiency (LAD) P05107 (related)
H00083 Allograft rejection P05362 (related)
H00080 Systemic lupus erythematosus P05362 (marker)
H00527 Retinitis pigmentosa (RP) P22748 (related)