Species

KNApSAcK Entry

Organism name Forsythia koreana
Genus Forsythia
Family Oleaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Forsythia viridissima var. koreana
Linked NCBI taxonomy ID 205692
Linked level varietas

Family

Family in NCBI taxonomy Oleaceae
ID 4144

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (6)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00002744 External link 512 Forsythiaside
/ Forsythoside A
CHEMBL504363
C058049
1 / 0 / 0 No. 33
C00007190 External link 512 (+)-Pinoresinol
CHEMBL267963
CHEMBL487611
CHEMBL460862
C103298
7 / 5 / 6 No. 38 No. 21
C00000647 External link 512 (+)-Phillygenin
CHEMBL457587
No. 38 No. 21
C00000609 External link 512 (-)-Arctigenin
CHEMBL369142
CHEMBL435734
CHEMBL1966556
C071942
13 / 7 / 6 No. 223 No. 21
C00000606 External link 512 (-)-Matairesinol
CHEMBL425148
C068935
1 / 0 / 0 No. 223 No. 21
C00000604 External link 512 (-)-Secoisolariciresinol
CHEMBL368347
C060283
2 / 1 / 1 1 / 0 No. 282 No. 21

Human Protein / Gene in interactions

22 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000604 C00000609 1 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000604 C00000609 0 / 1
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00000609 0 / 0
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00007190 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00007190 0 / 3
P17252 Protein kinase C alpha type Alpha C00002744 0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00007190 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000609 0 / 1
P04278 Sex hormone-binding globulin Secreted protein C00000606 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00000609 2 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00000609 0 / 0
Q99700 Ataxin-2 Unclassified protein C00000609 1 / 1
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00007190 5 / 3
P28482 Mitogen-activated protein kinase 1 Erk C00000609 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000609 0 / 0
O15118 Niemann-Pick C1 protein Unclassified protein C00000609 1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00007190 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000609 1 / 1
Q02750 Dual specificity mitogen-activated protein kinase kinase 1 Ste7 C00000609 1 / 1
Q9UNA4 DNA polymerase iota Enzyme C00000609 0 / 0
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00007190 0 / 0
Q9H0H5 Rac GTPase-activating protein 1 Unclassified protein C00007190 0 / 0

1 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
8856 NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR nuclear receptor subfamily 1, group I, member 2 C00000604

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (12)

OMIM preferred title UniProt
%606641 Body mass index; bmi P37231
#615279 Cardiofaciocutaneous syndrome 3; cfc3 Q02750
#609338 Carotid intimal medial thickness 1 P37231
#114500 Colorectal cancer; crc P84022
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#137800 Glioma susceptibility 1; glm1 P37231
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#257220 Niemann-pick disease, type c1; npc1 O15118
#601665 Obesity P37231
#183090 Spinocerebellar ataxia 2; sca2 Q99700

KEGG DISEASE (12)

KEGG name UniProt
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00523 Noonan syndrome and related disorders Q02750 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)