Species

KNApSAcK Entry

Organism name Osmanthus fragrans
Genus Osmanthus
Family Oleaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Osmanthus fragrans
Linked NCBI taxonomy ID 93977
Linked level species

Family

Family in NCBI taxonomy Oleaceae
ID 4144

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (6)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00000647 External link 512 (+)-Phillygenin
CHEMBL457587
No. 38 No. 21
C00010787 External link 512 10-Acetoxyligustroside
No. 243
C00001248 External link 512 Dodecane
CHEMBL30959
C007548
1 / 0 / 0 3 / 2 No. 877
C00029811 External link 512 Benzyl alcohol
/ (Hydroxymethyl)benzene
CHEMBL720
D019905
94 / 41 / 36 1 / 6 No. 885
C00003047 External link 512 Linalool
/ (R)-linalool
/ (R)-(-)-3,7-Dimethyl-1,6-octadien-3-ol
CHEMBL25306
CHEMBL235672
C018584
6 / 8 / 2 35 / 4 No. 958 No. 34
C00029816 External link 512 beta-Ionone
CHEMBL559945
No. 2480 No. 38

Human Protein / Gene in interactions

101 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00029811 1 / 0
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00003047 3 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00029811 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00029811 0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00029811 2 / 2
P08246 Neutrophil elastase S1A C00029811 2 / 1
P33765 Adenosine receptor A3 Adenosine receptor C00029811 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00029811 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00029811 0 / 0
P29466 Caspase-1 C14 C00029811 0 / 0
P17252 Protein kinase C alpha type Alpha C00029811 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00029811 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00029811 2 / 2
P16473 Thyrotropin receptor Glycohormone receptor C00029811 3 / 2
P10828 Thyroid hormone receptor beta NR1A2 C00003047 3 / 1
P00918 Carbonic anhydrase 2 Lyase C00029811 1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00029811 0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00029811 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00029811 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00029811 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00029811 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00029811 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00029811 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00029811 0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00029811 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00029811 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00029811 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00029811 0 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00029811 1 / 8
P11473 Vitamin D3 receptor NR1I1 C00029811 2 / 3
P14416 D(2) dopamine receptor Dopamine receptor C00029811 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00029811 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00029811 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00029811 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00029811 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00029811 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00029811 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00029811 1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00029811 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00029811 1 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00029811 0 / 0
O60656 UDP-glucuronosyltransferase 1-9 Enzyme C00029811 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00029811 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00029811 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00029811 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00029811 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00029811 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00029811 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00029811 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00029811 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00029811 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00029811 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00029811 1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00029811 0 / 0
P08311 Cathepsin G S1A C00029811 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00029811 1 / 0
P03956 Interstitial collagenase M10A C00029811 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00029811 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00003047 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00029811 0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00029811 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00029811 0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00029811 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00029811 2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00029811 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00029811 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00029811 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00029811 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00029811 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00029811 0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00029811 1 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00029811 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00029811 2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00029811 0 / 0
Q9Y4X1 UDP-glucuronosyltransferase 2A1 Enzyme C00003047 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00029811 0 / 0
P03372 Estrogen receptor NR3A1 C00029811 1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00029811 1 / 0
P22303 Acetylcholinesterase Hydrolase C00029811 1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00029811 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00029811 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00029811 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00029811 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00029811 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00029811 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00029811 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00003047 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00029811 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00029811 0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00029811 0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00003047 5 / 1
P19224 UDP-glucuronosyltransferase 1-6 Enzyme C00029811 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00029811 0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00029811 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00029811 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00029811 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00029811 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00029811 1 / 1
P06239 Tyrosine-protein kinase Lck Src C00029811 0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00029811 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00001248 0 / 0

39 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
3552 IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1 interleukin 1, alpha C00001248
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00001248
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00001248
1646 AKR1C2, AKR1C-pseudo, BABP, DD, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8 aldo-keto reductase family 1, member C2 (EC:1.3.1.20 1.1.1.357) C00003047
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00003047
1386 ATF2, CRE-BP1, CREB2, HB16, TREB7 activating transcription factor 2 (EC:2.3.1.48) C00003047
329 BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1 baculoviral IAP repeat containing 2 C00003047
330 BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2 baculoviral IAP repeat containing 3 C00003047
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00003047
1027 CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 cyclin-dependent kinase inhibitor 1B (p27, Kip1) C00003047
1028 CDKN1C, BWCR, BWS, KIP2, WBS, p57, p57Kip2 cyclin-dependent kinase inhibitor 1C (p57, Kip2) C00003047
1030 CDKN2B, CDK4I, INK4B, MTS2, P15, TP15, p15INK4b cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) C00003047
1447 CSN2, CASB casein beta C00003047
1509 CTSD, CLN10, CPSD cathepsin D (EC:3.4.23.5) C00003047
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00003047
1906 EDN1, ET1, HDLCQ7, PPET1 endothelin 1 C00003047
1956 EGFR, ERBB, ERBB1, HER1, PIG61, mENA epidermal growth factor receptor (EC:2.7.10.1) C00003047
2335 FN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF fibronectin 1 C00003047
1647 GADD45A, DDIT1, GADD45 growth arrest and DNA-damage-inducible, alpha C00003047
2729 GCLC, GCL, GCS, GLCL, GLCLC glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) C00003047
3156 HMGCR, LDLCQ3 3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) C00003047
3297 HSF1, HSTF1 heat shock transcription factor 1 C00003047
3320 HSP90AA1, EL52, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP2 heat shock protein 90kDa alpha (cytosolic), class A member 1 C00003047
3308 HSPA4, APG-2, HS24/P52, HSPH2, RY, hsp70, hsp70RY heat shock 70kDa protein 4 C00003047
3316 HSPB2, HSP27, Hs.78846, LOH11CR1K, MKBP heat shock 27kDa protein 2 C00003047
3398 ID2, GIG8, ID2A, ID2H, bHLHb26 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein C00003047
3638 INSIG1, CL-6, CL6 insulin induced gene 1 C00003047
3725 JUN, AP-1, AP1, c-Jun jun proto-oncogene C00003047
8850 KAT2B, CAF, P, P/CAF, PCAF K(lysine) acetyltransferase 2B (EC:2.3.1.48) C00003047
4193 MDM2, ACTFS, HDMX, hdm2 MDM2 oncogene, E3 ubiquitin protein ligase C00003047
4609 MYC, MRTL, MYCC, bHLHe39, c-Myc v-myc avian myelocytomatosis viral oncogene homolog C00003047
4790 NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 C00003047
4852 NPY, PYY4 neuropeptide Y C00003047
100124292 C00003047
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00003047
7295 TXN, TRDX, TRX, TRX1 thioredoxin C00003047
7471 WNT1, BMND16, INT1, OI15 wingless-type MMTV integration site family, member 1 C00003047
26118 WSB1, SWIP1, WSB-1 WD repeat and SOCS box containing 1 C00003047
231 AKR1B1, ADR, ALDR1, ALR2, AR aldo-keto reductase family 1, member B1 (aldose reductase) (EC:1.1.1.21) C00029811

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (49)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#615363 Estrogen resistance; estrr P03372
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#143500 Gilbert syndrome P22309
P22310
#137800 Glioma susceptibility 1; glm1 P04626
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#603932 Intervertebral disc disease; idd P14780
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#126200 Multiple sclerosis, susceptibility to; ms P08575
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#607276 Resting heart rate, variation in P08588
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#190300 Tremor, hereditary essential, 1; etm1 P35462
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (38)

KEGG name UniProt
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H00208 Hyperbilirubinemia P22309 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)

Diseases related to CTD interactions

10 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D017453 Dermatitis, Irritant C00001248
C00003047
C00029811
D001145 Arrhythmias, Cardiac C00029811
D006937 Hypercholesterolemia C00003047
D007938 Leukemia C00003047
D009369 Neoplasms C00003047
D004890 Erythema C00001248
D004342 Drug Hypersensitivity C00029811
D007022 Hypotension C00029811
D010264 Paraplegia C00029811
D011843 Radiculopathy C00029811