Catha edulis
Species
KNApSAcK Entry
| Organism name | Catha edulis |
|---|---|
| Genus | Catha |
| Family | Celastraceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Catha edulis |
|---|---|
| Linked NCBI taxonomy ID | 123405 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Celastraceae |
|---|---|
| ID | 4305 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Natural Activity
List (20)
| Species | Activity |
|---|---|
| Catha edulis (vahl) Forrsk. Ex Endl. | Anorectic |
| Catha edulis (vahl) Forrsk. Ex Endl. | Aperitif |
| Catha edulis (vahl) Forrsk. Ex Endl. | Aphrodisiac |
| Catha edulis (vahl) Forrsk. Ex Endl. | Astringent |
| Catha edulis (vahl) Forrsk. Ex Endl. | Cardiotonic |
| Catha edulis (vahl) Forrsk. Ex Endl. | Cardiotoxic |
| Catha edulis (vahl) Forrsk. Ex Endl. | Carminative |
| Catha edulis (vahl) Forrsk. Ex Endl. | CNS-Stimulant |
| Catha edulis (vahl) Forrsk. Ex Endl. | Euphoriant |
| Catha edulis (vahl) Forrsk. Ex Endl. | Hypertensive |
| Catha edulis (vahl) Forrsk. Ex Endl. | Inebrian |
| Catha edulis (vahl) Forrsk. Ex Endl. | Insecticide |
| Catha edulis (vahl) Forrsk. Ex Endl. | Mutagenic |
| Catha edulis (vahl) Forrsk. Ex Endl. | Mydriatic |
| Catha edulis (vahl) Forrsk. Ex Endl. | Myodepressant |
| Catha edulis (vahl) Forrsk. Ex Endl. | Narctotic |
| Catha edulis (vahl) Forrsk. Ex Endl. | Neurotonic |
| Catha edulis (vahl) Forrsk. Ex Endl. | Stimulant |
| Catha edulis (vahl) Forrsk. Ex Endl. | Sympathomimetic |
| Catha edulis (vahl) Forrsk. Ex Endl. | Tonic |
Metabolite list (16)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00008722
|
Ampelopsin 3-rhamnoside
|
No. 12 | No. 14 |
|
||||
|
C00013112
|
Cathedulin K 6
/ Catheduline K 6 |
No. 43 |
|
|||||
|
C00013110
|
Cathedulin K 1
/ Catheduline K 1 |
No. 43 |
|
|||||
|
C00013111
|
Cathedulin K 2
/ Catheduline K 2 |
No. 43 |
|
|||||
|
C00013114
|
Cathedulin K 15
/ Catheduline K 15 |
No. 43 |
|
|||||
|
C00001967
|
Catheduline E2
|
No. 168 |
|
|||||
|
C00013133
|
Cathidine D
|
No. 168 |
|
|||||
|
C00013167
|
Cathedulin 8
/ Cathedulin E 8 / Catheduline E 8 / (3alpha,4alpha,5beta,5aalpha,6alpha,7alpha,9alpha,9aalpha)-[6,7-bis(Acetyloxy)-5-(benzoyloxy)octahydro-4-hydroxy-2,2,9-trimethyl-5aH-3,9a-methano-1-benzoxepin-5a-yl]methyl ester 3-pyridinecarboxylic acid |
No. 168 |
|
|||||
|
C00003753
|
Pristimerin
|
CHEMBL54804
CHEMBL227090 CHEMBL1486063 |
C009043
|
13 / 21 / 47 | No. 403 | No. 51 |
|
|
|
C00013113
|
Cathedulin K 12
/ Catheduline K 12 |
No. 1988 |
|
|||||
|
C00013108
|
Cathedulin 5
/ Catheduline 5 / Catheduline E 5 / Catheduline E 6 6-acetate |
No. 1988 |
|
|||||
|
C00013109
|
Cathedulin E6
|
No. 1988 |
|
|||||
|
C00013116
|
Cathedulin K 20
/ Catheduline K 20 |
No. 1988 |
|
|||||
|
C00013115
|
Cathedulin K 19
/ Catheduline K 19 |
No. 1988 |
|
|||||
|
C00001405
|
D-Cathine
|
CHEMBL61006
CHEMBL136560 CHEMBL1412041 CHEMBL1574804 CHEMBL1616525 CHEMBL1788114 CHEMBL2092846 |
13 / 13 / 13 | No. 2149 | No. 9 |
|
||
|
C00001406
|
D-Cathinone
|
CHEMBL1124
CHEMBL2104047 |
1 / 0 / 0 | No. 2578 | No. 9 |
|
Human Protein / Gene in interactions
25 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001405 C00003753 | 0 / 1 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00001405 C00003753 | 0 / 0 |
| P18054 | Arachidonate 12-lipoxygenase, 12S-type | Enzyme | C00003753 | 2 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00001405 | 11 / 10 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001405 | 0 / 1 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00003753 | 2 / 3 |
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00003753 | 0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00001405 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00001405 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00001405 | 0 / 0 |
| P35348 | Alpha-1A adrenergic receptor | Adrenergic receptor | C00001405 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00003753 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00003753 | 4 / 1 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00003753 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001405 | 0 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00003753 | 2 / 2 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00003753 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001405 | 1 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001405 | 1 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00003753 | 4 / 3 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00003753 | 7 / 37 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00003753 | 1 / 1 |
| P35368 | Alpha-1B adrenergic receptor | Adrenergic receptor | C00001405 | 0 / 0 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00001405 | 0 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00001406 | 0 / 0 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (34)
| OMIM | preferred title | UniProt |
|---|---|---|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P18054
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #133239 | Esophageal cancer |
P04637
P18054 |
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #211980 | Lung cancer |
P04637
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (59)
| KEGG | name | UniProt |
|---|---|---|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00033 | Adrenal carcinoma |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|