Species

KNApSAcK Entry

Organism name Carthamus tinctorius
Genus Carthamus
Family Asteraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Carthamus tinctorius
Linked NCBI taxonomy ID 4222
Linked level species

Family

Family in NCBI taxonomy Asteraceae
ID 4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (31)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00005308 External link 512 6-Hydroxykaempferol 3,6-diglucoside
No. 1 No. 15
C00005169 External link 512 Nicotiflorin
/ Nicotifloroside
/ Kaempferol 3-O-rutinoside
/ Kaempferol 3-O-(alpha-L-rhamnopyranosyl(1->6)-beta-D-glucopyranoside
/ (-)-Kaempferol 3-O-(alpha-L-rhamnopyranosyl(1->6)-beta-D-glucopyranoside
CHEMBL431610
CHEMBL79790
CHEMBL255020
CHEMBL501550
CHEMBL498879
CHEMBL1419228
CHEMBL1875691
22 / 10 / 12 No. 1 No. 15
C00005427 External link 512 Quercetin 3,7-diglucoside
/ Quercetin 3,7-O-beta-diglucopyranoside
/ Quercetin 3,7-di-O-beta-D-glucopyranoside
CHEMBL1797051
No. 1 No. 15
C00005138 External link 512 Astragalin
/ Kaempferol 3-glucoside
/ Kaempferol 3-O-beta-D-glucoside
/ Kaempferol 3-O-beta-D-glucopyranoside
CHEMBL233930
CHEMBL453290
CHEMBL1572115
C001579
10 / 6 / 7 0 / 1 No. 2 No. 15
C00013868 External link 512 Quercetin 7-(6''-acetylglucoside)
/ 7-[(6-O-Acetyl-beta-D-glucopyranosyl)oxy]-2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-4H-1-benzopyran-4-one
No. 2 No. 15
C00005306 External link 512 6-Hydroxykaempferol 3-glucoside
No. 2 No. 15
C00001051 External link 512 6-Hydroxykaempferol
CHEMBL455504
No. 3 No. 15
C00004593 External link 512 6-Methoxykaempferol
/ 3,5,7,4'-Tetrahydroxy-6-methoxyflavone
/ 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one
CHEMBL462898
No. 3 No. 15
C00005311 External link 512 6-Hydroxykaempferol 3,6,7-triglucoside
No. 5 No. 15
C00005310 External link 512 6-Hydroxykaempferol 3-rutinoside-6-glucoside
No. 5 No. 15
C00008231 External link 512 Carthamidin 5-glucoside
No. 12 No. 14
C00000001 External link 512 GA1
/ Gibberellin A1
C422660
No. 40 No. 41
C00000003 External link 512 GA3
/ Gibberellin A3
CHEMBL513241
CHEMBL566653
CHEMBL1232952
CHEMBL1476967
CHEMBL1487394
C007842
10 / 18 / 17 No. 40 No. 41
C00000029 External link 512 GA29
/ Gibberellin A29
No. 40 No. 41
C00000020 External link 512 GA20
/ Gibberellin A20
No. 40 No. 41
C00014329 External link 512 5,6,7,4'-Tetrahydroxyflavanone 6,7-diglucoside
No. 48 No. 14
C00001230 External link 512 Nervonic acid
C013147
No. 184 No. 68
C00000019 External link 512 GA19
/ Gibberellin A19
C120175
No. 187 No. 41
C00000606 External link 512 (-)-Matairesinol
CHEMBL425148
C068935
1 / 0 / 0 No. 223 No. 21
C00006339 External link 512 Carthamin
C103141
No. 2732
C00006340 External link 512 Safflor yellow B
No. 2732
C00014588 External link 512 Anhydrosafflor yellow B
No. 2732
C00014589 External link 512 Precarthamin
No. 2732
C00014590 External link 512 Tinctormine
No. 3392
C00006246 External link 512 Safflor yellow A
No. 3392
C00001292 External link 512 Safynol
No. 4550
C00001281 External link 512 Dehydrosafynol
No. 4550
C00046653 External link 512 Cartorimine
/ (-)-Cartorimine
No. 5821
C00029911 External link 512 Carthamoside A1
/ (-)-Carthamoside A1
/ 4',6'-Acetonide-8Z-decane-4,6-diyne-1-O-beta-D-glucopyranoside
No. 6395
C00006418 External link 512 Safflomin C
No. 7435
C00002372 External link 512 Carthamone
No. 8443 No. 13

Human Protein / Gene in interactions

36 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q99700 Ataxin-2 Unclassified protein C00005138 C00005169 1 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00005138 C00005169 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00005138 C00005169 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00005138 C00005169 1 / 1
O75496 Geminin Unclassified protein C00000003 C00005169 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00005138 C00005169 0 / 0
P07237 Protein disulfide-isomerase Enzyme C00005138 C00005169 0 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00005169 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000003 0 / 1
P02545 Prelamin-A/C Unclassified protein C00000003 11 / 10
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00005169 1 / 0
P11473 Vitamin D3 receptor NR1I1 C00005169 2 / 3
P04278 Sex hormone-binding globulin Secreted protein C00000606 0 / 0
P39748 Flap endonuclease 1 Enzyme C00005169 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00000003 2 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00005169 1 / 1
P15121 Aldose reductase Enzyme C00005138 0 / 0
P06746 DNA polymerase beta Enzyme C00005169 0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00005169 1 / 1
P83916 Chromobox protein homolog 1 Unclassified protein C00000003 0 / 0
P14679 Tyrosinase Oxidoreductase C00005138 4 / 2
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000003 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00005138 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000003 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000003 0 / 1
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000003 1 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00005169 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00005169 0 / 0
P10275 Androgen receptor NR3C4 C00000003 3 / 4
Q9UBT6 DNA polymerase kappa Enzyme C00005169 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00005169 0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00005169 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00005169 1 / 4
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00005169 0 / 0
P01215 Glycoprotein hormones alpha chain Unclassified protein C00005138 0 / 3
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00005169 2 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (31)

OMIM preferred title UniProt
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P84022
Q14191
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#232300 Glycogen storage disease ii P10253
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#275210 Restrictive dermopathy, lethal P02545
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#277700 Werner syndrome; wrn Q14191
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (34)

KEGG name UniProt
H00081 Hashimoto's thyroiditis P01215 (marker)
H00082 Graves' disease P01215 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P01215 (marker)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H01171 Poor drug metabolism (PM) P33261 (related)
H00192 Xanthinuria P47989 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D003876 Dermatitis, Atopic C00005138