Species

KNApSAcK Entry

Organism name Xylopia vieillardi
Genus Xylopia
Family Annonaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Xylopia
Linked NCBI taxonomy ID 225838
Linked level genus

Family

Family in NCBI taxonomy Annonaceae
ID 22140

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Magnoliophyta
ID 3398

Metabolite list (12)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00001806 External link 512 Anolobine
/ (-)-Anolobine
CHEMBL257746
No. 20 No. 4
C00001869 External link 512 Isoboldine
/ (S)-Isoboldine
CHEMBL462880
19 / 22 / 55 No. 20 No. 4
C00028727 External link 512 Nornantenine
CHEMBL1254951
1 / 0 / 0 No. 20 No. 4
C00027307 External link 512 Calycinine
/ (-)-Calycinine
CHEMBL226824
No. 20 No. 4
C00001928 External link 512 Xylopine
/ (-)-Xylopine
CHEMBL227689
CHEMBL452201
C062700
No. 20 No. 4
C00025676 External link 512 Norglaucin
/ Norglaucine
/ (+)-Norglaucine
/ O,O-Dimethyllaurelliptine
No. 20 No. 4
C00025655 External link 512 Corytuberine
/ (+)-Corytuberine
CHEMBL227965
C013896
1 / 0 / 0 No. 20 No. 4
C00025319 External link 512 Oxoxylopin
/ Oxoxylopine
/ Lanuginosine
CHEMBL389400
1 / 4 / 2 No. 74
C00027457 External link 512 Oxoglaucine
/ O-Methylatheroline
CHEMBL470881
C111587
25 / 27 / 24 No. 74
C00001885 External link 512 Escholin
/ Escholine
/ Thalictrin
/ Thalictrine
/ Magnoflorine
/ (+)-Magnoflorine
CHEMBL235428
C001670
No. 286 No. 4
C00001910 External link 512 Reticuline
/ (+)-Reticuline
CHEMBL235212
CHEMBL401501
CHEMBL464734
C003298
1 / 0 / 0 No. 345 No. 4
C00026021 External link 512 Pycnarrhine
/ Dehydrocorypalline
CHEMBL1618006
No. 4925

Human Protein / Gene in interactions

37 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001869 C00027457 1 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001869 C00027457 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00001869 C00027457 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00001869 C00027457 4 / 3
P29466 Caspase-1 C14 C00001869 C00027457 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001869 C00027457 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001869 C00027457 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001869 C00027457 1 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001869 C00027457 0 / 1
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00001869 C00027457 2 / 2
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001869 C00027457 1 / 2
P00734 Prothrombin S1A C00025319 4 / 2
P42858 Huntingtin Unclassified protein C00027457 1 / 1
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00027457 2 / 0
O75496 Geminin Unclassified protein C00027457 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00027457 1 / 1
P00352 Retinal dehydrogenase 1 Enzyme C00001869 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00027457 0 / 0
P39748 Flap endonuclease 1 Enzyme C00027457 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00027457 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001869 3 / 3
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00027457 1 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00027457 0 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00028727 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00001910 0 / 0
P55210 Caspase-7 C14 C00001869 0 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 C00025655 0 / 0
P02545 Prelamin-A/C Unclassified protein C00027457 11 / 10
Q92793 CREB-binding protein Enzyme C00027457 1 / 1
P06746 DNA polymerase beta Enzyme C00027457 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00027457 0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00001869 7 / 37
P46063 ATP-dependent DNA helicase Q1 Enzyme C00001869 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00027457 1 / 1
O00255 Menin Unclassified protein C00001869 2 / 5
Q13951 Core-binding factor subunit beta Unclassified protein C00001869 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00001869 1 / 4

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (44)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P84022
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#600274 Frontotemporal dementia; ftd P10636
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#143100 Huntington disease; hd P42858
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#211980 Lung cancer P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#275210 Restrictive dermopathy, lethal P02545
#180849 Rubinstein-taybi syndrome 1; rsts1 Q92793
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601367 Stroke, ischemic P00734
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (71)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00504 Rubinstein-Taybi syndrome Q92793 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)