PCIDB

Dehaasia triandra

Species

KNApSAcK Entry

Organism name Dehaasia triandra
Genus Dehaasia
Family Lauraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Dehaasia
Linked NCBI taxonomy ID 128612
Linked level genus

Family

Family in NCBI taxonomy Lauraceae
ID 3433

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Magnoliophyta
ID 3398

Metabolite list (18)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00028135 External link 512 Dehatrine
C082415
No. 10 No. 4
C00027596 External link 512 Thalrugosinone
No. 10 No. 4
C00025265 External link 512 Homoaromoline
/ Homothalicrine
/ (+)-Homoaromoline
/ (+)-Thalrugosamine
CHEMBL507220
CHEMBL503522
CHEMBL509855
CHEMBL1185978
No. 10 No. 4
C00001895 External link 512 Obaberine
CHEMBL464525
No. 10 No. 4
C00025655 External link 512 Corytuberine
/ (+)-Corytuberine
CHEMBL227965
C013896
1 / 0 / 0 No. 20 No. 4
C00001872 External link 512 Isocorydine
/ (+)-Isocorydine
/ L-(+)-Isocorydine
/ (S)-(+)-Isocorydine
CHEMBL489525
CHEMBL1376826
14 / 7 / 10 No. 20 No. 4
C00025675 External link 512 Lauroscholtzine
/ 2-O-Methylboldine
/ N-Methyllaurotetanine
/ (+)-N-Methyllaurotetanine
CHEMBL464099
1 / 1 / 0 No. 20 No. 4
C00027150 External link 512 Nantenine
/ (+)-Domestine
/ (+)-Nantenine
CHEMBL179440
CHEMBL467094
C041615
38 / 10 / 2 No. 20 No. 4
C00001869 External link 512 Isoboldine
/ (S)-Isoboldine
CHEMBL462880
19 / 22 / 55 No. 20 No. 4
C00027438 External link 512 Sanjoinine Ib
/ Norisocorydine
CHEMBL465212
No. 20 No. 4
C00027566 External link 512 Nandigerine
/ Hernangerine
/ (+)-Nandigerine
/ (+)-Hernangerine
CHEMBL1190170
No. 20 No. 4
C00027225 External link 512 N-Methyllindcarpine
/ (+)-N-Methyllindcarpine
No. 20 No. 4
C00001812 External link 512 Atheroline
C001827
No. 74
C00027170 External link 512 Xanthoplanine
/ (+)-Xanthoplanine
CHEMBL1180065
No. 286 No. 4
C00027537 External link 512 Dehydroisocorydione
No. 305
C00027590 External link 512 Secoxanthoplanine
No. 639
C00027387 External link 512 Sonodione
/ Isocorydione
No. 2415
C00027439 External link 512 Norisocorydione
No. 2415

Human Protein / Gene in interactions

63 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001869 C00001872 1 / 0
Q01196 Runt-related transcription factor 1 Unclassified protein C00001869 C00001872 1 / 4
Q13951 Core-binding factor subunit beta Unclassified protein C00001869 C00001872 0 / 1
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001869 C00001872 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001869 C00001872 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001869 C00001872 1 / 1
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001869 C00001872 3 / 3
P00352 Retinal dehydrogenase 1 Enzyme C00001869 C00001872 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001869 C00001872 0 / 1
P24941 Cyclin-dependent kinase 2 Cdc2 C00001872 C00025655 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001869 0 / 0
P21918 D(1B) dopamine receptor Dopamine receptor C00027150 1 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00027150 0 / 0
P34969 5-hydroxytryptamine receptor 7 Serotonin receptor C00027150 0 / 0
P47898 5-hydroxytryptamine receptor 5A Serotonin receptor C00027150 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00027150 1 / 0
P35367 Histamine H1 receptor Histamine receptor C00027150 0 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00027150 2 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00027150 0 / 0
P28566 5-hydroxytryptamine receptor 1E Serotonin receptor C00027150 0 / 0
P28222 5-hydroxytryptamine receptor 1B Serotonin receptor C00027150 0 / 0
O75496 Geminin Unclassified protein C00001872 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00027150 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00027150 0 / 0
P35348 Alpha-1A adrenergic receptor Adrenergic receptor C00027150 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00027150 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00027150 0 / 0
P46098 5-hydroxytryptamine receptor 3A NS C00027150 0 / 0
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00027150 0 / 0
Q9H3N8 Histamine H4 receptor Histamine receptor C00027150 0 / 0
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00027150 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00027150 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00027150 2 / 0
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00027150 1 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00027150 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001872 0 / 0
P25021 Histamine H2 receptor Histamine receptor C00027150 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00001869 2 / 2
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00027150 1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00027150 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00027150 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00027150 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00027150 0 / 0
P55210 Caspase-7 C14 C00001869 0 / 0
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00027150 0 / 1
P29466 Caspase-1 C14 C00001869 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00027150 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00001869 4 / 3
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00025675 1 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00027150 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00027150 0 / 0
P28221 5-hydroxytryptamine receptor 1D Serotonin receptor C00027150 0 / 0
P35368 Alpha-1B adrenergic receptor Adrenergic receptor C00027150 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00027150 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00001869 0 / 0
Q9Y5N1 Histamine H3 receptor Histamine receptor C00027150 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00001869 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00001872 1 / 0
O00255 Menin Unclassified protein C00001869 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001869 1 / 2
P21728 D(1A) dopamine receptor Dopamine receptor C00027150 0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00001869 7 / 37
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001872 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (34)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103780 Alcohol dependence P08172
P14416
P31645
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#606798 Blepharospasm, benign essential P21918
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#133239 Esophageal cancer P04637
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#211980 Lung cancer P04637
#608516 Major depressive disorder; mdd P08172
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#159900 Myoclonic dystonia P14416
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#614674 Periodic fever, menstrual cycle-dependent P08908
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#607276 Resting heart rate, variation in P08588
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#190300 Tremor, hereditary essential, 1; etm1 P35462

KEGG DISEASE (57)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00079 Asthma P07550 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)