Species

KNApSAcK Entry

Organism name Papaver bracteatum
Genus Papaver
Family Papaveraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Papaver bracteatum
Linked NCBI taxonomy ID 215227
Linked level species

Family

Family in NCBI taxonomy Papaveraceae
ID 3465

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (10)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00006658 External link 512 Cyanidin 3-sophoroside
No. 1 No. 15
C00001823 External link 512 Bracteoline
CHEMBL410604
CHEMBL1316470
C002507
13 / 18 / 47 No. 20 No. 4
C00001873 External link 512 Isothebaine
C111588
No. 20 No. 4
C00015402 External link 512 alpha-Thebaol
/ 3,6-Dimethoxy-4-hydroxyphenanthrene
No. 104 No. 27
C00015302 External link 512 O-Methylthebaol
/ O-Methyl-alpha-thebaol
/ 3,4,6-Trimethoxyphenanthrene
No. 104 No. 27
C00001916 External link 512 Salutaridine
/ (+)-Salutaridine
CHEMBL402782
CHEMBL404097
C009270
3 / 4 / 2 No. 426 No. 4
C00001893 External link 512 Neopine
No. 1983 No. 4
C00001924 External link 512 Thebaine
/ (-)-Thebaine
/ Paramorphine
CHEMBL403893
CHEMBL1318110
D013797
4 / 0 / 0 No. 1983 No. 4
C00028775 External link 512 Oripavine
CHEMBL437602
C005283
1 / 0 / 0 No. 1983 No. 4
C00029115 External link 512 Thebaine N-oxide
No. 1983 No. 4

Human Protein / Gene in interactions

19 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P35372 Mu-type opioid receptor Opioid receptor C00001916 C00001924 C00028775 0 / 0
P00734 Prothrombin S1A C00001916 4 / 2
P29466 Caspase-1 C14 C00001823 0 / 0
P34969 5-hydroxytryptamine receptor 7 Serotonin receptor C00001823 0 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 C00001916 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001823 0 / 1
P00352 Retinal dehydrogenase 1 Enzyme C00001823 0 / 0
O75496 Geminin Unclassified protein C00001924 0 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00001924 0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00001823 7 / 37
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001823 3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00001823 2 / 2
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001823 1 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001823 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001823 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00001924 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00001823 4 / 3
Q9UBT6 DNA polymerase kappa Enzyme C00001823 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001823 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (22)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#133239 Esophageal cancer P04637
#600274 Frontotemporal dementia; ftd P10636
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#211980 Lung cancer P04637
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601367 Stroke, ischemic P00734
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188050 Thrombophilia due to thrombin defect; thph1 P00734

KEGG DISEASE (49)

KEGG name UniProt
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00033 Adrenal carcinoma P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)