Stephania tetrandra
Species
KNApSAcK Entry
| Organism name | Stephania tetrandra |
|---|---|
| Genus | Stephania |
| Family | Menispermaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Stephania tetrandra |
|---|---|
| Linked NCBI taxonomy ID | 425106 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Menispermaceae |
|---|---|
| ID | 3455 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | eudicotyledons |
|---|---|
| ID | 71240 |
Natural Activity
List (28)
| Species | Activity |
|---|---|
| Stephania tetrandra S. Moore | Analgesic |
| Stephania tetrandra S. Moore | Antiaggregant |
| Stephania tetrandra S. Moore | Antiallergic |
| Stephania tetrandra S. Moore | Antianginal |
| Stephania tetrandra S. Moore | Antiarrhythmic |
| Stephania tetrandra S. Moore | Antiasthmatic |
| Stephania tetrandra S. Moore | Antiatherogenic |
| Stephania tetrandra S. Moore | Anticollagen |
| Stephania tetrandra S. Moore | Antiedemic |
| Stephania tetrandra S. Moore | Antifibrotic |
| Stephania tetrandra S. Moore | Antiinflammatory |
| Stephania tetrandra S. Moore | Antileukotriene |
| Stephania tetrandra S. Moore | Antioxidant |
| Stephania tetrandra S. Moore | Antiphagocytotic |
| Stephania tetrandra S. Moore | Antipyretic |
| Stephania tetrandra S. Moore | Antirheumatic |
| Stephania tetrandra S. Moore | Antiseptic |
| Stephania tetrandra S. Moore | Antithromboxane |
| Stephania tetrandra S. Moore | Antitumor |
| Stephania tetrandra S. Moore | Calcium Antagonist |
| Stephania tetrandra S. Moore | Carminative |
| Stephania tetrandra S. Moore | Diuretic |
| Stephania tetrandra S. Moore | Hypotensive |
| Stephania tetrandra S. Moore | Immunodepressant |
| Stephania tetrandra S. Moore | Laxative |
| Stephania tetrandra S. Moore | Myorelaxant |
| Stephania tetrandra S. Moore | NKC-inhibitor |
| Stephania tetrandra S. Moore | NO-Inhibitor |
Metabolite list (12)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00028699
|
N-Methylfangchinoline
/ (+)-2-N-Methylfangchinoline |
No. 10 | No. 4 |
|
||||
|
C00001919
|
Tetrandrine
/ (+)-Tetrandrine |
CHEMBL176045
CHEMBL367260 CHEMBL445477 CHEMBL449690 CHEMBL504958 CHEMBL504757 |
C009438
|
26 / 23 / 48 | 6 / 16 | No. 10 | No. 4 |
|
|
C00025760
|
Frangchinoline
/ 7-O-Demethyltetrandrine |
CHEMBL504256
CHEMBL509803 CHEMBL500614 |
12 / 6 / 3 | No. 10 | No. 4 |
|
||
|
C00027360
|
Fenfangjine C
|
No. 10 | No. 4 |
|
||||
|
C00001834
|
Cassythicine
/ (+)-Cassythicine / N-Methylactinodaphnine / (+)-N-Methylactinodaphnine |
CHEMBL464528
|
No. 20 | No. 4 |
|
|||
|
C00025827
|
Corydine
/ Glaucentrin / (+)-Corydine / Glaucentrine |
CHEMBL489524
CHEMBL2002847 |
C067341
|
1 / 0 / 0 | No. 20 | No. 4 |
|
|
|
C00027566
|
Nandigerine
/ Hernangerine / (+)-Nandigerine / (+)-Hernangerine |
CHEMBL1190170
|
No. 20 | No. 4 |
|
|||
|
C00014693
|
Stephaflavone A
/ 5,5'-Dihydroxy-7,7'-dimethoxy-2,2'-bis(4-methoxyphenyl)-[3,6'-bi-4H-1-benzopyran]-4,4'-dione |
No. 34 | No. 18 |
|
||||
|
C00014694
|
Stephaflavone B
/ 5,5'-Dihydroxy-2-(4-hydroxyphenyl)-7,7'-dimethoxy-2'-(4-methoxyphenyl)-[3,6'-bi-4H-1-benzopyran]-4,4'-dione |
No. 34 | No. 18 |
|
||||
|
C00027361
|
Fenfangjine F
/ (-)-Fenfangjine F |
No. 639 |
|
|||||
|
C00027363
|
Fenfangjine H
|
No. 815 |
|
|||||
|
C00027362
|
Fenfangjine G
|
No. 3886 |
|
Human Protein / Gene in interactions
31 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00001919 C00025760 | 2 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00001919 C00025760 | 1 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00001919 C00025760 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00001919 C00025760 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00001919 C00025760 | 1 / 1 |
| O75496 | Geminin | Unclassified protein | C00001919 C00025760 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00001919 C00025760 | 0 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | C00001919 C00025760 | 1 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001919 | 1 / 0 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00001919 | 0 / 0 |
| P24941 | Cyclin-dependent kinase 2 | Cdc2 | C00025827 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001919 | 0 / 1 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00025760 | 0 / 0 |
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00001919 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00001919 | 0 / 0 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00025760 | 0 / 1 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00025760 | 1 / 1 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00001919 | 0 / 0 |
| Q9HC16 | DNA dC->dU-editing enzyme APOBEC-3G | Enzyme | C00001919 | 0 / 0 |
| P06280 | Alpha-galactosidase A | Enzyme | C00001919 | 1 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001919 | 0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00001919 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001919 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001919 | 0 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00001919 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00001919 | 4 / 1 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00001919 | 1 / 1 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00001919 | 7 / 37 |
| Q8IUX4 | DNA dC->dU-editing enzyme APOBEC-3F | Enzyme | C00025760 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00001919 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001919 | 1 / 2 |
6 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 5243 | ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) |
C00001919
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00001919
|
| 332 | BIRC5, API4, EPR-1 | baculoviral IAP repeat containing 5 |
C00001919
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00001919
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00001919
|
| 1577 | CYP3A5, CP35, CYPIIIA5, P450PCN3, PCN3 | cytochrome P450, family 3, subfamily A, polypeptide 5 (EC:1.14.14.1) |
C00001919
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (24)
| OMIM | preferred title | UniProt |
|---|---|---|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #133239 | Esophageal cancer |
P04637
|
| #301500 | Fabry disease |
P06280
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #211980 | Lung cancer |
P04637
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
KEGG DISEASE (50)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00125 | Fabry disease |
P06280
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
Diseases related to CTD interactions
16 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D000860 | Anoxia |
C00001919
|
| D001855 | Bone Marrow Diseases |
C00001919
|
| D006331 | Heart Diseases |
C00001919
|
| D006470 | Hemorrhage |
C00001919
|
| D007239 | Infection |
C00001919
|
| D007511 | Ischemia |
C00001919
|
| D015470 | Leukemia, Myeloid, Acute |
C00001919
|
| D008106 | Liver Cirrhosis, Experimental |
C00001919
|
| D055370 | Lung Injury |
C00001919
|
| D028361 | Mitochondrial Diseases |
C00001919
|
| D052016 | Mucositis |
C00001919
|
| D009203 | Myocardial Infarction |
C00001919
|
| D009336 | Necrosis |
C00001919
|
| D016066 | Pleural Effusion, Malignant |
C00001919
|
| D013280 | Stomatitis |
C00001919
|
| D013927 | Thrombosis |
C00001919
|