PCIDB

Stephania macrantha

Species

KNApSAcK Entry

Organism name Stephania macrantha
Genus Stephania
Family Menispermaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Stephania
Linked NCBI taxonomy ID 147243
Linked level genus

Family

Family in NCBI taxonomy Menispermaceae
ID 3455

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (8)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00001872 External link 512 Isocorydine
/ (+)-Isocorydine
/ L-(+)-Isocorydine
/ (S)-(+)-Isocorydine
CHEMBL489525
CHEMBL1376826
14 / 7 / 10 No. 20 No. 4
C00025655 External link 512 Corytuberine
/ (+)-Corytuberine
CHEMBL227965
C013896
1 / 0 / 0 No. 20 No. 4
C00025827 External link 512 Corydine
/ Glaucentrin
/ (+)-Corydine
/ Glaucentrine
CHEMBL489524
CHEMBL2002847
C067341
1 / 0 / 0 No. 20 No. 4
C00025241 External link 512 Kikemanin
/ Kikemanine
/ Corydalmine
/ Schefferine
/ (-)-Kikemanine
/ (-)-Corydalmine
CHEMBL448891
CHEMBL1209608
CHEMBL2334894
C058198
5 / 3 / 0 No. 37 No. 4
C00026150 External link 512 Tetrahydropalmatine
/ dl-Tetrahydropalmatine
/ (+/-)-Tetrahydropalmatine
CHEMBL187892
CHEMBL487182
CHEMBL2334889
8 / 5 / 2 No. 37 No. 4
C00026094 External link 512 Stepholidine
/ (-)-Stepholidine
CHEMBL487387
CHEMBL2334890
C010513
7 / 4 / 0 0 / 1 No. 37 No. 4
C00027159 External link 512 Depiline
/ Palmatine
/ Berbericinine
/ O,O-Dimethyldemethyleneberberine
CHEMBL206106
C005413
8 / 13 / 13 8 / 0 No. 155 No. 4
C00001875 External link 512 Tritopin
/ Tritopine
/ Laudanidine
/ (-)-Laudanidine
CHEMBL251625
CHEMBL1425007
2 / 0 / 0 No. 345 No. 4

Human Protein / Gene in interactions

26 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P13726 Tissue factor Membrane receptor C00025241 C00026094 C00026150 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00025241 C00026094 C00026150 0 / 0
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00025241 C00026094 C00026150 1 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001872 C00026150 C00027159 0 / 1
P24941 Cyclin-dependent kinase 2 Cdc2 C00001872 C00025655 C00025827 0 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00025241 C00026094 C00026150 0 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00025241 C00026094 C00026150 2 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001872 C00027159 1 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001872 C00001875 0 / 0
O75496 Geminin Unclassified protein C00001872 C00001875 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001872 C00027159 1 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001872 C00027159 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001872 C00027159 0 / 1
P00352 Retinal dehydrogenase 1 Enzyme C00001872 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00027159 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001872 3 / 3
P03372 Estrogen receptor NR3A1 C00026150 1 / 1
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00026150 1 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00026094 0 / 0
P21918 D(1B) dopamine receptor Dopamine receptor C00026094 1 / 0
P02545 Prelamin-A/C Unclassified protein C00027159 11 / 10
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001872 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00001872 1 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00001872 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00001872 1 / 4
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00027159 0 / 0

8 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
332 BIRC5, API4, EPR-1 baculoviral IAP repeat containing 5 C00027159
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00027159
6348 CCL3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3 chemokine (C-C motif) ligand 3 C00027159
6351 CCL4, ACT2, AT744.1, G-26, HC21, LAG-1, LAG1, MIP-1-beta, MIP1B, MIP1B1, SCYA2, SCYA4 chemokine (C-C motif) ligand 4 C00027159
6352 CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP chemokine (C-C motif) ligand 5 C00027159
3570 IL6R, CD126, IL-6R-1, IL-6RA, IL6Q, IL6RA, IL6RQ, gp80 interleukin 6 receptor C00027159
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00027159
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00027159

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (24)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#103780 Alcohol dependence P14416
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#606798 Blepharospasm, benign essential P21918
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615363 Estrogen resistance; estrr P03372
#137800 Glioma susceptibility 1; glm1 O75874
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#614674 Periodic fever, menstrual cycle-dependent P08908
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#275210 Restrictive dermopathy, lethal P02545

KEGG DISEASE (21)

KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D004409 Dyskinesia, Drug-Induced C00026094